Inhibitor |
BIRB-0796 (Doramapimod)
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining
Sort descending
|
Standard Deviation |
|
p38 alpha MAPK
|
3
|
0
|
|
JNK2
|
4
|
0
|
|
p38 beta MAPK
|
13
|
4
|
|
VEGFR1
|
14
|
0
|
|
RSK1
|
34
|
2
|
|
p38 gamma MAPK
|
35
|
3
|
|
p38 delta MAPK
|
40
|
5
|
|
FGF-R1
|
40
|
4
|
|
BRSK2
|
47
|
6
|
|
RSK2
|
48
|
6
|
|
Lck
|
51
|
7
|
|
GSK3 beta
|
53
|
7
|
|
MKK1
|
55
|
4
|
|
EPH-B3
|
57
|
3
|
|
PIM3
|
60
|
3
|
|
MELK
|
60
|
2
|
|
SYK
|
62
|
0
|
|
PKC alpha
|
62
|
2
|
|
MARK3
|
62
|
4
|
|
PHK
|
67
|
7
|
|
PKA
|
68
|
4
|
|
JNK3
|
68
|
0
|
|
CSK
|
69
|
1
|
|
PAK4
|
70
|
5
|
|
SGK1
|
72
|
1
|
|
IGF-1R
|
72
|
0
|
|
PRK2
|
73
|
7
|
|
YES1
|
73
|
4
|
|
CHK1
|
73
|
2
|
|
IKK beta
|
74
|
4
|
|
EPH-A2
|
75
|
5
|
|
AMPK
|
75
|
2
|
|
IRR
|
75
|
11
|
|
Aurora C
|
78
|
6
|
|
ROCK 2
|
79
|
2
|
|
MNK1
|
79
|
1
|
|
PIM1
|
80
|
3
|
|
Aurora B
|
82
|
1
|
|
DYRK2
|
82
|
4
|
|
PAK6
|
82
|
0
|
|
CDK2-Cyclin A
|
83
|
6
|
|
CAMK1
|
84
|
6
|
|
MSK1
|
84
|
5
|
|
IKK epsilon
|
85
|
5
|
|
NEK2a
|
86
|
5
|
|
NEK6
|
86
|
2
|
|
PDK1
|
86
|
5
|
|
PLK1
|
86
|
9
|
|
CAMKK beta
|
87
|
2
|
|
MST2
|
88
|
6
|
|
PKB beta
|
89
|
2
|
|
MAPKAP-K3
|
89
|
3
|
|
PKB alpha
|
89
|
7
|
|
JNK1
|
90
|
1
|
|
MNK2
|
90
|
0
|
|
PAK5
|
92
|
2
|
|
TBK1
|
92
|
1
|
|
EF2K
|
92
|
3
|
|
Src
|
93
|
4
|
|
PKD1
|
93
|
7
|
|
PRAK
|
93
|
4
|
|
SmMLCK
|
94
|
1
|
|
SRPK1
|
94
|
1
|
|
ERK2
|
95
|
10
|
|
ERK8
|
95
|
6
|
|
CAMKK alpha
|
95
|
4
|
|
CK2
|
96
|
5
|
|
DYRK1A
|
97
|
5
|
|
CK1 delta
|
97
|
8
|
|
ERK1
|
97
|
0
|
|
S6K1
|
99
|
6
|
|
HIPK2
|
99
|
2
|
|
MST4
|
100
|
14
|
|
DYRK3
|
101
|
4
|
|
BTK
|
101
|
0
|
|
NEK7
|
103
|
0
|
|
HIPK3
|
103
|
1
|
|
MAPKAP-K2
|
105
|
3
|
|
IR
|
113
|
0
|
|
PKC zeta
|
116
|
6
|
|
CHK2
|
117
|
0
|
|
PIM2
|
124
|
5
|
Screen Conc:
0.10µM
| Kinase |
% Activity Remaining
Sort descending
|
Standard Deviation |
|
JNK2
|
27
|
1
|
|
p38 alpha MAPK
|
28
|
4
|
|
MKK1
|
61
|
8
|
|
VEGFR1
|
66
|
0
|
|
p38 beta MAPK
|
69
|
1
|
|
p38 gamma MAPK
|
75
|
4
|
|
SYK
|
76
|
0
|
|
IGF-1R
|
77
|
12
|
|
FGF-R1
|
81
|
12
|
|
PAK4
|
83
|
2
|
|
PKB alpha
|
84
|
20
|
|
RSK1
|
86
|
12
|
|
MAPKAP-K2
|
87
|
5
|
|
SGK1
|
88
|
7
|
|
IRR
|
88
|
14
|
|
MST4
|
88
|
4
|
|
Src
|
88
|
1
|
|
DYRK2
|
88
|
3
|
|
Lck
|
88
|
4
|
|
CAMK1
|
88
|
4
|
|
PKC zeta
|
89
|
7
|
|
p38 delta MAPK
|
89
|
1
|
|
AMPK
|
89
|
3
|
|
MARK3
|
91
|
14
|
|
ROCK 2
|
91
|
9
|
|
IR
|
91
|
1
|
|
MSK1
|
91
|
3
|
|
PIM2
|
91
|
3
|
|
MNK2
|
91
|
1
|
|
DYRK3
|
91
|
6
|
|
PKA
|
92
|
6
|
|
CSK
|
93
|
2
|
|
PAK6
|
93
|
4
|
|
BRSK2
|
94
|
0
|
|
CHK2
|
94
|
2
|
|
IKK beta
|
94
|
9
|
|
DYRK1A
|
94
|
0
|
|
YES1
|
94
|
7
|
|
SmMLCK
|
95
|
2
|
|
S6K1
|
95
|
27
|
|
HIPK2
|
95
|
0
|
|
PIM1
|
95
|
1
|
|
TBK1
|
95
|
4
|
|
PIM3
|
95
|
11
|
|
CAMKK beta
|
95
|
0
|
|
MST2
|
95
|
16
|
|
CHK1
|
96
|
7
|
|
IKK epsilon
|
96
|
6
|
|
PRAK
|
96
|
5
|
|
ERK2
|
97
|
8
|
|
CK1 delta
|
97
|
10
|
|
NEK2a
|
98
|
3
|
|
PRK2
|
98
|
3
|
|
Aurora B
|
98
|
0
|
|
ERK1
|
99
|
5
|
|
PDK1
|
99
|
10
|
|
PKB beta
|
100
|
11
|
|
NEK6
|
100
|
3
|
|
EPH-B3
|
100
|
4
|
|
PKD1
|
100
|
11
|
|
MNK1
|
100
|
1
|
|
PLK1
|
100
|
17
|
|
RSK2
|
100
|
8
|
|
SRPK1
|
100
|
0
|
|
EF2K
|
102
|
1
|
|
JNK1
|
102
|
0
|
|
CDK2-Cyclin A
|
102
|
11
|
|
ERK8
|
103
|
6
|
|
BTK
|
106
|
1
|
|
GSK3 beta
|
107
|
0
|
|
MELK
|
108
|
20
|
|
PAK5
|
108
|
10
|
|
EPH-A2
|
112
|
0
|
|
PKC alpha
|
113
|
6
|
|
PHK
|
117
|
11
|
|
CK2
|
120
|
13
|
