Inhibitor | MSC 2032964A  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
MSC 2032964A   C16H13F3N6O 362.31 ASK1 Guo X. (2010) EMBO Molecular Medicine 2 504-515

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ASK1 11 0
CLK2 40 4
CK1 delta 59 2
MKK1 61 17
RSK1 65 8
MKK2 69 4
TIE2 69 1
YES1 74 19
PRK2 75 8
MLK1 75 2
JNK3 79 12
IGF-1R 79 11
GSK3 beta 79 6
p38 gamma MAPK 80 3
TrkA 81 5
DYRK1A 81 9
IKK beta 82 29
MPSK1 83 6
IRAK4 83 4
EF2K 84 3
PKC zeta 84 6
ZAP70 84 14
TAK1 84 2
MKK6 85 16
CDK2-Cyclin A 85 5
MARK1 86 6
PKD1 86 14
MARK3 86 11
MLK3 87 8
HER4 88 3
STK33 88 7
PKA 88 6
CHK2 89 10
IRAK1 89 3
CSK 89 5
Aurora B 89 1
RIPK2 89 3
RSK2 89 7
p38 delta MAPK 90 8
DYRK2 90 5
JNK2 90 10
TLK1 90 6
PAK5 91 9
JNK1 91 11
DYRK3 91 6
MEKK1 91 4
MNK2 91 2
PDK1 92 10
MELK 92 9
HIPK1 92 8
PHK 92 3
OSR1 92 7
PAK6 93 10
MST2 93 1
EPH-A4 93 10
PKC alpha 94 11
IRR 94 5
PKB beta 94 4
MARK2 94 21
EPH-B1 94 1
Lck 95 8
MSK1 95 6
BRSK1 95 3
PIM3 95 11
EPH-B2 95 7
DAPK1 95 3
TTK 96 13
IKK epsilon 96 7
HIPK3 96 13
Aurora A 96 0
NEK2a 96 1
EPH-B4 96 7
MAPKAP-K3 97 3
ROCK 2 97 5
ABL 97 6
NUAK1 98 8
PRAK 98 10
PIM1 98 9
MNK1 98 13
MAPKAP-K2 99 7
EPH-B3 99 7
JAK2 100 1
IR 100 13
SGK1 100 11
EPH-A2 100 9
FGF-R1 101 17
NEK6 101 2
BTK 101 9
Src 102 5
CK2 102 4
TBK1 102 3
ERK2 102 7
ERK8 102 5
SRPK1 102 8
PAK4 102 1
S6K1 103 9
PLK1 103 2
CHK1 104 1
PKB alpha 104 7
EIF2AK3 104 9
SYK 104 32
PAK2 104 6
LKB1 105 18
TAO1 105 7
CAMKK beta 105 13
HIPK2 105 4
PKC gamma 106 6
MST4 106 2
SmMLCK 106 11
p38 beta MAPK 107 9
AMPK 108 6
VEGFR1 108 8
GCK 108 3
PIM2 108 0
CAMK1 109 11
BRSK2 109 1
p38 alpha MAPK 114 1
ERK1 116 1
MARK4 119 4
MINK1 120 1
BRK 124 8
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ASK1 54 7
MKK1 76 3
ZAP70 77 16
MLK1 80 1
CLK2 82 12
TrkA 83 6
JNK2 84 11
YES1 87 2
RIPK2 87 2
MARK3 87 17
VEGFR1 88 2
PAK6 88 9
JNK3 88 1
HER4 88 9
IGF-1R 89 14
PKC alpha 89 9
p38 delta MAPK 90 5
IRAK4 90 6
MKK2 90 16
MARK1 90 4
BRSK1 90 10
SRPK1 90 9
PDK1 91 10
GSK3 beta 92 4
DYRK1A 92 7
DYRK2 92 4
CK1 delta 93 7
AMPK 93 1
EPH-A2 93 6
SmMLCK 93 5
JNK1 93 1
PKB alpha 95 17
EPH-B3 95 7
DAPK1 95 10
CSK 95 2
HIPK1 96 14
CAMKK beta 96 4
PIM1 96 6
ERK2 96 3
MPSK1 96 15
NEK2a 97 10
Lck 97 0
CDK2-Cyclin A 98 5
PAK4 98 2
SYK 99 11
MNK1 99 8
TLK1 99 4
MST4 99 2
TTK 99 14
PKA 99 1
CHK1 99 2
IRAK1 100 13
JAK2 100 16
TBK1 101 5
PIM3 101 3
TAO1 101 0
p38 gamma MAPK 102 12
HIPK3 102 16
RSK1 102 4
MAPKAP-K2 102 9
PKD1 103 12
BTK 103 12
Aurora B 103 15
TIE2 103 5
PKB beta 103 5
GCK 103 11
IRR 104 9
S6K1 104 12
EPH-B4 104 5
PRK2 104 4
MLK3 104 7
TAK1 105 20
FGF-R1 105 9
STK33 106 12
RSK2 106 0
IKK epsilon 106 15
ROCK 2 106 14
Src 107 6
MELK 107 13
ABL 108 21
EPH-B2 108 4
MEKK1 108 7
PIM2 109 15
ERK8 110 17
MKK6 110 1
PKC zeta 111 30
MARK4 111 6
PRAK 112 4
NEK6 113 12
MINK1 113 18
MSK1 114 1
PAK5 114 2
MAPKAP-K3 114 11
OSR1 114 5
CHK2 114 16
IR 115 30
PHK 115 0
PKC gamma 115 2
HIPK2 116 1
MST2 116 3
BRSK2 116 2
NUAK1 116 6
EIF2AK3 117 10
EF2K 118 16
DYRK3 119 15
EPH-B1 120 10
p38 beta MAPK 121 4
p38 alpha MAPK 121 18
EPH-A4 124 11
PAK2 126 3
CK2 127 16
ERK1 127 18
PLK1 128 12
Aurora A 128 3
CAMK1 128 7
BRK 130 4
LKB1 132 8
MNK2 139 23
SGK1 146 55
MARK2 209 146
IKK beta 217 95
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
p38 gamma MAPK 71 0
MKK1 72 11
ZAP70 76 19
PRK2 77 11
IKK beta 79 12
TrkA 80 11
YES1 81 5
MPSK1 82 7
OSR1 83 11
MARK3 83 12
JNK3 85 14
PKC alpha 87 5
JNK1 87 11
GSK3 beta 87 17
IGF-1R 88 4
MLK3 88 3
RIPK2 89 3
JNK2 89 3
IRAK4 90 15
MLK1 90 3
MKK2 90 12
MARK2 90 30
IRR 91 8
TAO1 91 9
PKD1 91 7
DYRK3 92 5
ERK2 92 5
CK1 delta 92 4
TAK1 92 7
Aurora B 93 11
TTK 93 9
CHK2 93 8
MARK1 93 1
MNK1 94 10
TIE2 94 8
DYRK1A 94 5
IRAK1 94 4
EPH-A2 95 0
ABL 95 6
MNK2 95 9
CDK2-Cyclin A 95 0
SmMLCK 96 5
PKC zeta 96 3
HIPK1 96 15
CSK 96 2
MEKK1 97 8
NEK2a 97 12
MELK 97 4
PAK5 97 6
PKB alpha 97 9
MAPKAP-K3 97 9
PKB beta 97 8
PRAK 97 15
STK33 97 2
PKA 98 4
ASK1 98 9
RSK1 99 12
PDK1 99 4
MAPKAP-K2 99 6
EF2K 99 0
EPH-B3 99 14
MST2 99 4
CK2 99 14
TBK1 99 0
SRPK1 100 10
MKK6 100 18
NUAK1 100 5
PAK6 100 3
Src 100 7
HIPK2 100 4
CLK2 101 9
EPH-A4 101 3
PKC gamma 101 3
HIPK3 101 9
p38 delta MAPK 102 1
ERK8 102 2
BRSK1 102 16
CHK1 103 3
SGK1 103 1
DYRK2 104 11
PHK 104 11
PIM3 104 1
PLK1 104 8
PIM1 104 17
ROCK 2 105 1
PIM2 106 3
EPH-B1 106 2
EPH-B4 106 5
MST4 106 1
Lck 106 2
p38 beta MAPK 106 4
HER4 106 2
IR 107 11
TLK1 107 9
LKB1 107 1
SYK 107 15
Aurora A 108 13
BTK 108 4
AMPK 108 8
CAMKK beta 108 4
EIF2AK3 109 15
VEGFR1 109 7
p38 alpha MAPK 109 10
PAK2 110 7
PAK4 111 18
FGF-R1 111 6
RSK2 112 2
DAPK1 112 6
GCK 112 6
MSK1 114 4
NEK6 114 3
JAK2 114 8
IKK epsilon 114 16
BRK 114 11
BRSK2 116 9
CAMK1 116 6
ERK1 120 13
EPH-B2 124 26
MINK1 125 2
S6K1 125 1
MARK4 127 4