Inhibitor | BIO (6-Bromoindirubin-3'-oxime)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 667463-62-9 5287844 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957 Polychronopoulos P. (2004) J. Med. Chem. 47 935

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
SGK1
0
 0
PHK
1
 0
SYK
2
 0
VEGFR1
2
 1
ERK8
2
 0
FGF-R1
2
 0
BTK
2
 0
S6K1
3
 0
YES1
4
 0
MELK
4
 1
PDK1
4
 0
CHK2
4
 0
CDK2-Cyclin A
5
 0
PIM3
5
 2
Src
5
 0
Lck
5
 2
AMPK
6
 0
IGF-1R
6
 2
CAMKK beta
6
 1
HIPK2
6
 3
TBK1
6
 0
MSK1
7
 1
CAMK1
7
 0
PAK4
7
 2
GSK3 beta
8
 6
MST2
8
 5
RSK1
9
 5
CHK1
9
 1
PAK5
9
 1
MARK3
10
 1
IKK epsilon 11 8
EPH-A2 11 1
MST4 11 0
NEK6 13 2
PIM2 14 4
DYRK1A 14 1
ROCK 2 14 0
SmMLCK 14 2
BRSK2 16 0
IRR 17 3
CSK 19 6
IR 20 3
PAK6 22 0
PIM1 22 1
PRAK 23 14
PKB beta 24 12
EPH-B3 25 8
PKC alpha 25 0
PKA 28 2
p38 beta MAPK 31 2
DYRK2 31 4
MAPKAP-K2 33 27
MKK1 34 5
CK1 delta 34 2
PLK1 36 0
RSK2 36 0
ERK1 41 2
p38 gamma MAPK 43 1
PRK2 46 5
JNK2 46 2
PKC zeta 47 5
DYRK3 48 1
JNK1 48 3
PKD1 52 8
p38 delta MAPK 53 11
p38 alpha MAPK 54 10
MNK1 56 1
SRPK1 57 0
MNK2 58 6
CK2 59 4
PKB alpha 67 4
IKK beta 68 6
NEK2a 81 5
EF2K 82 1
ERK2 83 4
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
PDK1
1
 0
ERK8
2
 0
BTK
2
 0
MST2
2
 0
HIPK2
3
 0
FGF-R1
3
 0
PHK
3
 0
Lck
3
 1
MELK
4
 2
YES1
4
 0
CHK2
4
 2
CDK2-Cyclin A
4
 0
Src
5
 1
VEGFR1
5
 2
AMPK
6
 0
TBK1
7
 1
RSK1
7
 1
GSK3 beta
8
 8
PAK4
9
 4
IKK epsilon
9
 0
CAMKK beta
9
 0
SGK1
9
 0
CAMK1
10
 0
EPH-A2 11 0
IGF-1R 11 2
MST4 11 0
CHK1 12 3
PIM3 12 3
BRSK2 13 4
PAK5 13 0
SmMLCK 14 3
MARK3 17 4
SYK 17 20
IRR 18 3
CSK 20 0
S6K1 21 1
DYRK1A 22 0
PAK6 22 0
ROCK 2 24 1
PIM2 26 9
MSK1 27 2
EPH-B3 35 13
RSK2 35 3
MKK1 35 4
PIM1 35 2
PKC alpha 37 0
IR 38 3
p38 beta MAPK 41 0
DYRK2 44 2
PRAK 45 5
PRK2 45 7
p38 gamma MAPK 49 2
MNK2 50 0
PKB beta 51 6
PLK1 51 8
JNK2 53 1
MNK1 55 3
CK1 delta 57 3
JNK1 57 4
DYRK3 58 0
PKD1 66 3
ERK1 67 4
MAPKAP-K2 68 7
SRPK1 68 5
PKC zeta 69 4
p38 delta MAPK 70 0
p38 alpha MAPK 70 19
PKB alpha 72 3
NEK6 73 5
CK2 76 0
EF2K 81 2
PKA 81 4
IKK beta 86 6
ERK2 88 2
NEK2a 91 16
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
GSK3 beta
7
 0
TrkA 13 0
MLK3 14 3
BRSK1 14 3
Src 16 5
MST2 19 1
CAMK1 26 7
VEGFR1 27 1
BTK 29 4
CDK2-Cyclin A 29 1
Lck 38 2
AMPK 40 5
YES1 41 4
FGF-R1 43 5
MLK1 48 2
BRSK2 48 1
Aurora A 50 3
NUAK1 51 8
Aurora B 51 11
PHK 51 3
GCK 52 0
TBK1 54 0
JAK2 56 2
HIPK2 58 2
DAPK1 60 0
IGF-1R 63 5
CHK2 67 3
MINK1 67 1
TAK1 71 2
SmMLCK 71 6
MELK 71 1
MARK3 72 5
PIM3 73 3
IRAK4 74 8
SYK 75 9
EPH-A2 75 14
LKB1 75 1
ERK8 76 2
MNK2 76 2
PAK2 77 1
p38 beta MAPK 77 6
SGK1 77 10
CHK1 78 5
MEKK1 78 7
PAK4 78 7
IKK epsilon 80 12
CLK2 81 1
MARK4 81 4
RSK1 82 2
CAMKK beta 83 2
PDK1 84 6
EF2K 85 2
DYRK2 85 8
EPH-B2 85 6
TTK 86 6
PKB beta 86 1
CSK 87 8
EPH-A4 88 5
PIM2 88 8
IRR 88 2
JNK3 88 6
DYRK1A 91 5
MAPKAP-K2 91 2
MAPKAP-K3 91 11
CK2 92 1
PAK5 92 2
S6K1 93 6
EPH-B3 93 5
MARK2 94 5
p38 gamma MAPK 94 5
MSK1 94 8
ASK1 94 2
PLK1 95 6
MNK1 96 1
DYRK3 96 2
PKC zeta 96 1
PKC alpha 97 5
HIPK1 98 3
PIM1 99 7
HER4 100 1
MKK1 100 13
MARK1 100 8
PAK6 100 6
NEK2a 102 3
NEK6 102 8
EPH-B1 102 1
PRK2 103 2
PRAK 103 2
ERK1 104 3
MKK2 104 9
PKB alpha 104 2
p38 alpha MAPK 105 2
ROCK 2 105 8
JNK2 105 9
p38 delta MAPK 106 4
IKK beta 106 5
SRPK1 107 10
HIPK3 108 14
PKA 109 4
TAO1 109 7
JNK1 110 2
EPH-B4 111 3
CK1 delta 111 4
RIPK2 111 6
MST4 112 1
ERK2 112 12
PKD1 112 15
RSK2 114 6
MKK6 118 12
IR 129 12
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
Src 73 13
YES1 76 6
CHK2 77 19
CHK1 82 18
SmMLCK 84 19
GSK3 beta 85 9
MNK2 86 5
MELK 86 12
MST2 87 8
S6K1 87 10
CK1 delta 87 10
p38 beta MAPK 87 7
SRPK1 87 8
ERK1 88 13
NEK6 88 12
CDK2-Cyclin A 88 7
SGK1 88 8
EPH-B3 89 10
PKB alpha 89 10
Lck 89 10
PLK1 91 6
AMPK 91 21
BTK 93 12
IRR 93 8
ERK2 93 12
CAMKK beta 93 0
DYRK2 93 16
RSK2 93 4
EPH-A2 94 3
TBK1 94 13
JNK2 94 5
Aurora B 94 11
VEGFR1 95 6
FGF-R1 95 5
ERK8 95 10
PAK4 95 18
p38 gamma MAPK 95 1
MKK1 96 1
CK2 96 3
NEK2a 96 6
PIM3 96 8
MARK3 97 4
PRAK 97 3
CAMK1 97 17
MSK1 97 6
JNK1 98 6
MST4 98 4
PKD1 98 6
SYK 99 2
ROCK 2 100 5
PDK1 100 6
PIM1 100 10
PKB beta 100 3
HIPK2 101 2
PHK 101 18
IKK epsilon 101 0
PKA 102 1
DYRK1A 102 10
PAK6 102 16
MAPKAP-K2 103 6
PRK2 103 15
p38 alpha MAPK 103 22
IKK beta 106 11
IGF-1R 106 8
IR 107 0
RSK1 107 3
PAK5 107 0
PKC zeta 107 12
p38 delta MAPK 108 10
EF2K 108 9
DYRK3 108 4
CSK 109 9
PIM2 111 5
BRSK2 112 5
PKC alpha 113 1
MNK1 118 4