Inhibitor | BI-D-1870  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BI-D-1870   C19H23N5O2F2 391.42 501437-28-1 25023738 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
RSK1
0
 0
RSK2
4
 1
PLK1
6
 2
MINK1
7
 3
Aurora B
7
 1
MST2
7
 0
MLK3
8
 4
MELK
9
 0
CDK2-Cyclin A 15 2
MLK1 16 4
TAO1 18 2
PIM3 19 0
VEGFR1 19 0
Aurora A 24 0
MST4 25 2
CLK2 26 7
MARK3 31 5
IRAK4 31 5
GSK3 beta 35 3
GCK 37 3
ERK8 39 8
CAMKK beta 40 7
S6K1 41 3
PIM1 43 1
IRR 43 7
NUAK1 44 4
TAK1 49 8
MARK2 51 4
AMPK 55 2
IGF-1R 57 3
PAK4 58 0
NEK2a 59 4
TrkA 60 1
DYRK1A 60 4
HIPK2 61 1
PKD1 61 0
STK33 62 0
TTK 63 2
CK1 delta 63 1
Lck 63 7
MKK2 64 4
JAK2 66 3
PAK6 70 4
Src 72 11
SmMLCK 73 6
MSK1 73 0
PAK5 73 1
ERK2 74 5
PRK2 74 2
MKK1 74 3
ROCK 2 76 0
BRSK2 76 5
CSK 76 0
MARK4 77 7
PKC gamma 77 7
CAMK1 78 11
DYRK3 80 8
YES1 82 15
SGK1 83 0
PKA 83 7
JNK2 83 0
DAPK1 83 2
CHK2 84 5
PDK1 84 7
DYRK2 85 1
MARK1 85 2
BRSK1 86 0
EPH-B1 86 1
SYK 87 8
IR 88 0
PAK2 88 0
PRAK 88 6
HER4 89 4
MAPKAP-K3 89 1
ABL 90 3
SRPK1 90 4
EF2K 90 6
HIPK1 90 5
MNK1 90 4
p38 alpha MAPK 91 0
TIE2 91 4
MAPKAP-K2 91 5
IKK epsilon 91 0
RIPK2 92 0
CK2 92 1
LKB1 92 3
EPH-B2 93 4
PKC zeta 93 0
p38 delta MAPK 93 2
ERK1 94 5
EPH-B4 94 6
BTK 95 7
MNK2 95 3
BRK 95 10
TBK1 95 10
PKC alpha 96 14
p38 gamma MAPK 98 11
NEK6 98 8
EPH-A2 98 12
PIM2 99 12
JNK3 99 3
IKK beta 101 4
ASK1 102 3
PKB alpha 102 7
PKB beta 103 10
JNK1 104 0
EPH-A4 105 5
MPSK1 105 2
p38 beta MAPK 107 4
MKK6 108 5
PHK 108 3
MEKK1 108 13
CHK1 108 11
FGF-R1 108 13
EPH-B3 109 4
ZAP70 112 8
HIPK3 113 2
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
RSK1
1
 0
RSK2
2
 5
PLK1
5
 1
Aurora B 22 4
MELK 40 5
MST2 41 3
VEGFR1 59 2
PKD1 62 11
PIM3 65 3
CAMKK beta 72 12
CHK1 73 0
IRR 75 5
PIM1 75 1
Aurora C 76 4
MST4 77 8
GSK3 beta 77 5
MARK3 78 5
BRSK2 78 9
IGF-1R 79 3
FGF-R1 79 11
PKC zeta 80 1
ERK8 81 6
CK1 delta 81 5
PAK4 81 11
ROCK 2 83 13
ERK2 84 1
CDK2-Cyclin A 84 0
Lck 85 0
YES1 86 0
MNK1 87 9
EF2K 87 0
p38 alpha MAPK 87 12
IKK epsilon 88 5
PKA 88 8
JNK1 88 6
PRAK 88 14
PAK5 89 5
MAPKAP-K2 89 14
DYRK2 90 0
DYRK3 90 3
PKC alpha 90 9
EPH-A2 91 3
CAMKK alpha 92 8
SYK 94 18
SRPK1 94 7
PDK1 94 7
DYRK1A 95 9
MNK2 96 11
Src 96 3
CHK2 96 2
JNK3 96 10
BTK 96 9
TBK1 97 1
NEK2a 97 10
PRK2 97 5
PKB alpha 97 1
CK2 97 4
CSK 98 8
MKK1 98 4
PIM2 100 8
p38 beta MAPK 100 4
PAK6 101 9
PKB beta 101 14
HIPK2 102 6
CAMK1 103 8
HIPK3 104 5
p38 delta MAPK 105 8
IKK beta 105 10
IR 106 4
SmMLCK 107 4
AMPK 107 6
MAPKAP-K3 108 12
NEK7 108 0
EPH-B3 109 6
p38 gamma MAPK 111 3
SGK1 111 7
ERK1 114 2
PHK 114 13
NEK6 114 8
JNK2 115 12
S6K1 119 8
MSK1 124 5
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
RSK2
1
 0
RSK1
2
 0
PLK1
2
 0
PIM3
3
 0
MELK
3
 0
VEGFR1
3
 0
MST4
3
 0
Aurora A
4
 0
MLK3
4
 0
Aurora B
4
 0
PIM1
6
 0
GCK
8
 2
MINK1
8
 5
TAO1
8
 2
TrkA
8
 2
CAMKK beta
9
 0
NUAK1
9
 0
TAK1
9
 2
CLK2 11 11
JAK2 12 0
PAK4 12 0
MLK1 12 6
MST2 12 1
FGF-R1 13 1
IR 13 2
IGF-1R 14 3
TIE2 15 3
HIPK2 15 1
STK33 20 1
IRR 20 1
GSK3 beta 21 3
BRSK2 21 1
YES1 23 6
MKK2 25 9
MARK4 27 0
TBK1 28 5
DYRK3 29 1
PAK5 29 0
CDK2-Cyclin A 30 6
TTK 30 8
IKK epsilon 31 3
CK1 delta 32 0
MARK1 33 5
Lck 34 1
PAK6 35 0
MARK3 36 2
SYK 36 5
PKC alpha 36 6
MARK2 38 0
ABL 40 2
ERK1 42 1
EPH-B3 43 1
BRSK1 43 0
PKC gamma 44 4
DYRK2 44 4
BTK 45 6
DYRK1A 46 6
SmMLCK 46 6
EPH-B2 48 4
MKK1 48 1
LKB1 49 2
EPH-B1 51 2
EPH-A2 52 0
PKD1 53 5
ERK8 54 8
S6K1 54 1
HER4 59 0
Src 59 3
CAMK1 60 9
PIM2 61 4
IRAK4 63 3
HIPK1 64 1
CHK2 65 2
EPH-A4 65 3
PKA 65 5
SGK1 67 11
PRK2 67 6
AMPK 67 1
MPSK1 69 2
ROCK 2 69 3
MSK1 70 7
JNK2 71 4
JNK3 71 1
HIPK3 72 4
PRAK 73 4
RIPK2 73 1
ERK2 73 0
PAK2 74 8
DAPK1 74 13
CHK1 74 6
IKK beta 74 3
MNK1 76 0
p38 alpha MAPK 76 11
PDK1 78 6
SRPK1 80 9
NEK2a 80 0
CSK 80 12
MKK6 80 1
JNK1 83 8
ZAP70 85 4
PKC zeta 86 6
MEKK1 86 6
MNK2 86 4
BRK 87 5
p38 delta MAPK 88 9
MAPKAP-K2 89 8
p38 gamma MAPK 89 4
p38 beta MAPK 90 9
MAPKAP-K3 92 3
NEK6 92 0
ASK1 93 3
PKB alpha 94 8
PKB beta 95 7
EF2K 96 0
CK2 99 3
PHK 99 4
EPH-B4 106 8
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
RSK1 14 2
RSK2 32 2
PLK1 33 1
Aurora B 53 5
MAPKAP-K3 57 4
MST2 65 8
IGF-1R 71 6
PHK 77 2
IRR 79 17
PIM3 79 10
PRK2 80 5
S6K1 83 3
GSK3 beta 84 0
PRAK 84 8
PKC zeta 84 9
PAK4 85 3
MELK 85 1
VEGFR1 88 2
NEK6 88 4
CDK2-Cyclin A 88 5
PAK6 88 0
p38 delta MAPK 89 0
p38 alpha MAPK 89 3
Lck 89 2
p38 beta MAPK 89 0
PKD1 89 5
DYRK1A 90 3
PKA 91 4
PAK5 91 5
BRSK2 91 4
CSK 91 1
BTK 92 7
MAPKAP-K2 92 6
NEK2a 93 4
JNK2 93 2
CAMK1 93 5
CK1 delta 93 0
ERK8 94 1
ERK2 95 2
MST4 95 8
IKK beta 95 5
JNK3 95 5
MSK1 95 5
ERK1 96 13
IR 96 6
HIPK2 97 9
CHK2 97 9
SRPK1 97 2
MNK1 98 6
CHK1 98 7
JNK1 98 4
PIM2 98 5
Src 98 1
CAMKK beta 98 12
SGK1 98 3
PDK1 99 4
p38 gamma MAPK 99 9
CK2 100 3
DYRK2 100 4
DYRK3 100 11
SYK 100 10
PKB beta 100 4
YES1 100 6
TBK1 101 2
AMPK 101 3
MARK3 101 0
PKC alpha 103 5
MKK1 103 4
ROCK 2 104 1
PIM1 104 0
EPH-A2 105 14
SmMLCK 106 4
EF2K 107 3
NEK7 107 8
IKK epsilon 107 1
PKB alpha 110 5
EPH-B3 118 13
MNK2 121 4
FGF-R1 131 54