Inhibitor | LY364947  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
LY364947   C17H12N4 272.31 396129-53-6 447966 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953 Li (2006) J.Med.Chem. 49 2138

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
RIPK2
7
 1
VEGFR1
7
 1
CK1 delta 11 4
ABL 14 3
MINK1 16 10
p38 alpha MAPK 18 0
PKD1 22 1
GCK 30 2
BRK 30 1
Lck 39 4
TAK1 41 1
YES1 48 6
FGF-R1 50 4
p38 beta MAPK 52 2
JNK3 57 4
BTK 61 16
Aurora B 61 4
JNK2 68 7
EPH-B3 69 4
MNK1 69 4
BRSK1 69 0
PIM3 71 8
GSK3 beta 71 26
Src 72 4
ERK2 73 7
ERK8 73 12
MSK1 74 2
MLK1 76 5
CLK2 77 3
EF2K 77 5
MKK1 77 6
MARK3 78 14
TAO1 78 8
p38 gamma MAPK 78 7
MARK2 79 0
NUAK1 79 5
DYRK1A 80 3
ERK1 81 3
CHK2 81 9
PRK2 82 1
MEKK1 82 11
NEK2a 83 6
PKC zeta 83 11
MKK2 83 4
IRAK1 84 4
S6K1 84 9
CAMK1 84 6
IKK beta 84 2
CDK2-Cyclin A 84 5
CK2 84 3
IRAK4 85 15
STK33 85 12
PIM2 85 9
CAMKK beta 85 23
IRR 86 7
p38 delta MAPK 86 17
EIF2AK3 86 14
PKA 87 8
IGF-1R 87 9
EPH-A2 87 17
NEK6 88 3
TTK 88 8
PAK2 89 7
MARK1 89 2
HIPK2 89 2
SGK1 90 4
DYRK3 90 0
TrkA 90 27
JAK2 90 6
LKB1 90 5
MELK 90 8
PKB beta 90 4
MPSK1 91 2
MST2 91 6
ROCK 2 91 1
MST4 91 10
DAPK1 91 4
CHK1 91 18
PRAK 91 8
BRSK2 92 6
CSK 92 9
PKB alpha 92 10
IR 92 1
Aurora A 93 4
RSK1 93 11
EPH-B4 93 1
HER4 93 13
JNK1 93 1
PKC gamma 93 14
EPH-B1 95 6
PHK 95 8
HIPK1 95 16
AMPK 96 3
PAK6 96 9
PKC alpha 96 10
MNK2 97 2
PIM1 97 3
SRPK1 97 5
TLK1 98 4
EPH-B2 98 1
PLK1 100 7
MARK4 100 3
MAPKAP-K3 100 6
PAK5 101 11
SYK 103 24
IKK epsilon 103 2
OSR1 104 10
SmMLCK 104 9
PDK1 104 12
TBK1 105 1
EPH-A4 106 7
MKK6 107 3
ASK1 108 10
ZAP70 109 8
MAPKAP-K2 109 12
MLK3 109 2
PAK4 110 7
TIE2 111 12
HIPK3 113 2
DYRK2 114 23
RSK2 116 30
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
RIPK2 16 4
VEGFR1 25 1
CK1 delta 31 1
MINK1 44 8
ABL 60 6
p38 alpha MAPK 63 6
PIM3 68 6
TAO1 69 1
GCK 71 3
FGF-R1 71 0
PKD1 74 10
ERK2 77 9
GSK3 beta 79 15
ERK8 79 1
YES1 81 17
MAPKAP-K3 83 4
TAK1 84 17
JNK1 84 1
JNK3 85 0
ERK1 85 13
JNK2 86 14
Lck 86 11
BRK 86 8
MLK1 86 2
HIPK2 87 1
MST4 87 6
p38 beta MAPK 87 1
CAMKK beta 87 4
S6K1 87 4
Aurora B 87 3
IR 88 5
EPH-B3 88 9
MARK2 89 9
DYRK3 90 3
MKK2 90 6
EPH-B1 91 4
CK2 91 7
MARK3 91 14
DYRK1A 91 10
PRK2 92 8
IRAK4 92 14
MARK1 93 2
PAK2 93 2
NEK2a 94 0
IKK beta 94 9
PIM2 94 12
CLK2 94 7
PKC zeta 94 9
STK33 94 3
EIF2AK3 94 1
HIPK1 95 7
MST2 95 3
PDK1 95 14
CHK2 95 5
BTK 95 7
CHK1 97 5
MKK1 97 16
IRR 97 16
SGK1 97 5
TTK 97 0
MSK1 97 8
HER4 98 1
LKB1 98 3
MKK6 98 4
PAK4 98 4
ASK1 99 2
TLK1 99 4
p38 gamma MAPK 99 2
RSK1 99 1
PHK 100 11
NUAK1 100 15
PIM1 100 12
CDK2-Cyclin A 100 3
p38 delta MAPK 100 7
ROCK 2 101 0
MNK1 101 0
IGF-1R 101 24
PRAK 101 9
Aurora A 101 9
MNK2 102 3
DAPK1 103 4
NEK6 103 11
PKC alpha 103 7
EPH-A2 103 9
SRPK1 103 0
JAK2 103 5
MARK4 103 13
PKB beta 104 3
IKK epsilon 104 9
EPH-A4 104 4
EF2K 104 1
PLK1 104 12
IRAK1 105 8
PKC gamma 105 14
OSR1 105 16
PKA 105 3
AMPK 106 6
SYK 106 8
PAK6 106 3
BRSK2 108 0
Src 109 2
PAK5 109 17
BRSK1 109 12
CSK 110 6
MEKK1 111 27
ZAP70 111 12
EPH-B4 111 2
MAPKAP-K2 112 27
SmMLCK 112 2
MPSK1 113 4
RSK2 114 20
PKB alpha 114 16
DYRK2 114 8
MLK3 115 22
HIPK3 116 10
TBK1 117 7
EPH-B2 117 8
TIE2 119 7
MELK 119 12
TrkA 119 13
CAMK1 120 1