Inhibitor | LDN-193189  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
VEGFR1	0	0
GCK	3	0
RIPK2	3	1
ABL	4	4
MINK1	4	2
NUAK1	5	1
BRK	5	0
CLK2	5	1
YES1	7	3
Lck	7	1
CAMKK beta	8	1
MLK3	8	0
FGF-R1	8	3
DYRK1A	9	0
ERK8	11	1
MARK3	11	1
STK33	11	0
TAK1	13	5
MARK1	14	3
Src	16	3
AMPK	18	1
MELK	18	2
BRSK2	20	4
PHK	21	1
CK1 delta	22	1
MARK4	24	6
TBK1	26	0
RSK1	29	3
TIE2	30	6
MARK2	32	1
PKD1	33	4
CDK2-Cyclin A	34	5
MNK2	34	1
SYK	36	7
IRR	37	1
EPH-B2	37	9
PRK2	37	0
TrkA	38	0
MNK1	39	8
CAMK1	45	3
EPH-B4	46	2
Aurora B	47	1
EPH-B3	48	7
EPH-A2	50	9
BTK	52	3
MKK2	52	9
IRAK4	53	0
PKC zeta	55	3
HER4	56	4
IKK epsilon	56	3
HIPK2	56	14
Aurora A	56	0
EPH-A4	57	10
RSK2	57	4
BRSK1	57	3
PKB beta	58	3
CHK2	59	1
PRAK	60	9
MEKK1	60	9
SmMLCK	60	3
MLK1	60	63
TTK	61	1
GSK3 beta	62	7
PAK4	62	4
MKK1	67	1
SGK1	70	4
CSK	72	6
p38 delta MAPK	72	3
PAK5	72	8
DAPK1	72	15
MAPKAP-K2	73	0
p38 alpha MAPK	75	4
MST2	76	2
DYRK2	77	7
JNK1	78	2
JAK2	79	5
NEK2a	79	6
SRPK1	79	6
EF2K	79	3
TAO1	79	11
LKB1	80	9
CK2	81	9
PKB alpha	81	25
DYRK3	81	34
PIM1	82	7
IKK beta	83	1
JNK2	83	9
S6K1	84	1
PIM3	84	4
MPSK1	84	2
HIPK1	85	6
ROCK 2	85	4
MAPKAP-K3	86	2
MSK1	87	7
PKC alpha	88	6
NEK6	88	5
IGF-1R	89	5
HIPK3	90	1
ERK1	90	1
ASK1	91	10
PLK1	91	1
PKC gamma	92	5
PIM2	92	6
p38 gamma MAPK	93	22
IR	93	4
PAK2	94	0
PKA	94	7
JNK3	94	5
p38 beta MAPK	96	3
CHK1	96	8
EPH-B1	100	11
PAK6	100	1
ZAP70	101	9
MKK6	104	1
PDK1	107	3
ERK2	107	4
MST4	181	8

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
RIPK2	2	0
ABL	6	0
GCK	11	1
CAMKK beta	13	1
MINK1	15	2
NUAK1	17	3
FGF-R1	20	5
YES1	21	1
BRK	21	0
CLK2	21	1
MLK3	33	2
MARK3	34	0
Lck	40	3
DYRK1A	40	2
TAK1	44	3
STK33	44	3
VEGFR1	48	57
ERK8	49	6
Src	52	1
MARK1	54	0
MELK	54	5
MARK4	58	1
AMPK	59	6
MNK2	60	18
PHK	60	5
TBK1	62	5
MARK2	63	13
MNK1	63	8
IRR	68	8
BRSK2	68	7
RSK2	69	5
ZAP70	69	3
PRK2	69	2
CK1 delta	69	2
MLK1	70	5
TrkA	71	2
EPH-B3	75	1
HER4	76	9
Aurora B	76	7
MAPKAP-K3	79	14
SGK1	79	5
p38 gamma MAPK	79	9
RSK1	79	6
SYK	80	5
EPH-B2	80	8
EPH-A2	81	5
PAK5	82	7
NEK6	83	0
PIM1	83	8
MEKK1	83	7
GSK3 beta	83	1
EPH-A4	83	3
PKD1	83	11
MSK1	83	8
p38 alpha MAPK	84	2
CDK2-Cyclin A	84	11
CAMK1	85	5
BRSK1	85	0
ROCK 2	86	7
TIE2	86	11
IKK epsilon	89	1
MKK6	89	5
ERK2	89	13
CK2	89	1
DYRK3	89	3
EPH-B4	89	8
ASK1	90	9
MAPKAP-K2	91	12
MKK2	91	6
PKB beta	91	4
DAPK1	91	5
HIPK2	91	2
IRAK4	91	1
Aurora A	91	1
S6K1	92	7
MKK1	93	4
PKC zeta	93	10
BTK	94	1
PAK4	94	1
EF2K	96	6
PKC alpha	96	4
PDK1	97	8
ERK1	97	4
JNK3	97	7
PKC gamma	97	2
LKB1	98	2
IKK beta	98	15
MPSK1	98	2
IGF-1R	99	17
HIPK1	99	3
PRAK	100	1
PLK1	100	1
PKA	101	0
JNK1	101	0
TTK	101	4
CSK	103	5
PKB alpha	103	17
PIM3	103	12
JNK2	103	11
CHK2	103	2
MST2	104	4
PIM2	104	3
JAK2	104	14
p38 beta MAPK	104	2
PAK6	107	5
IR	107	2
SmMLCK	107	7
DYRK2	107	2
PAK2	108	20
CHK1	109	9
TAO1	110	1
p38 delta MAPK	110	8
HIPK3	111	23
SRPK1	116	1
EPH-B1	116	21
NEK2a	119	14
MST4	123	16

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
GCK	37	3
CAMKK beta	43	9
ABL	43	2
VEGFR1	48	5
RIPK2	52	2
NUAK1	57	11
SGK1	62	10
PRK2	65	6
CLK2	67	3
FGF-R1	69	1
RSK2	73	8
YES1	73	4
TBK1	74	5
MINK1	74	3
DYRK1A	75	1
MARK4	75	9
MARK2	76	1
PKB beta	77	3
p38 gamma MAPK	78	11
MARK3	78	8
BRK	78	1
p38 alpha MAPK	78	13
NEK6	80	8
MAPKAP-K3	80	11
GSK3 beta	81	6
STK33	81	7
EPH-A2	81	15
MELK	81	15
Lck	81	2
MAPKAP-K2	81	5
IKK beta	81	26
SYK	82	8
PAK4	82	2
MNK1	82	6
IRR	82	7
PIM1	83	11
CDK2-Cyclin A	84	1
EPH-A4	84	6
TAK1	84	6
PHK	85	12
PDK1	85	6
ZAP70	86	5
CAMK1	86	15
DYRK3	86	9
RSK1	86	0
MLK3	86	1
TrkA	87	7
MKK6	87	5
ERK8	87	1
IKK epsilon	87	1
PKC zeta	88	11
IRAK4	88	9
BRSK1	88	7
BRSK2	88	4
EPH-B3	88	12
JNK2	88	5
HER4	88	13
MARK1	88	9
MKK2	88	6
PRAK	89	2
ERK1	89	8
p38 delta MAPK	89	0
TTK	89	4
ERK2	89	15
JNK1	89	7
DAPK1	89	6
p38 beta MAPK	89	22
CK2	90	9
MEKK1	90	4
MNK2	90	16
MSK1	91	4
CK1 delta	91	4
PKC alpha	92	10
PKD1	93	4
ASK1	93	6
HIPK2	93	2
Src	94	20
Aurora B	95	3
SRPK1	95	15
PAK5	95	14
EF2K	95	16
CSK	95	11
EPH-B4	96	6
AMPK	96	2
PLK1	97	8
MPSK1	97	7
HIPK1	97	1
PIM2	98	1
ROCK 2	98	1
JNK3	98	4
MKK1	98	4
PKA	99	3
PKC gamma	99	9
CHK2	99	5
JAK2	100	7
PAK2	100	3
Aurora A	100	10
CHK1	101	3
TIE2	102	10
TAO1	102	1
MST2	102	7
PKB alpha	102	8
HIPK3	104	5
SmMLCK	104	12
MLK1	104	2
PIM3	105	6
MST4	105	0
IR	105	5
DYRK2	108	4
EPH-B2	108	6
PAK6	108	7
LKB1	109	1
S6K1	110	20
BTK	111	5
IGF-1R	112	12
EPH-B1	117	13
NEK2a	118	13