Inhibitor | BML-258 (SK1-I)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BML-258 (SK1-I)   C17H28ClNO2 313.86 1072443-89-0 SphK1 Paugh S.W. (2008) Blood 112 1382-1391

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
TIE2 141 5
SYK 134 4
BRSK2 130 7
HER4 127 6
EPH-B1 126 14
YES1 123 1
EPH-B4 122 7
RIPK2 119 8
PIM3 118 4
JAK2 118 14
HIPK3 118 13
DYRK2 116 3
Aurora A 116 3
MST4 116 7
ZAP70 116 2
MAPKAP-K3 115 13
EPH-B2 115 5
ASK1 115 8
FGF-R1 115 6
MARK1 114 12
BRSK1 114 4
S6K1 114 8
PAK2 113 2
TBK1 111 13
MNK2 111 3
ABL 110 3
NEK2a 110 3
PKA 110 2
MSK1 110 6
ROCK 2 110 1
DAPK1 109 7
ERK1 108 23
HIPK2 108 8
MELK 108 2
PDK1 107 4
IR 107 7
PKD1 107 4
BTK 107 25
MINK1 107 14
PKC zeta 106 2
PLK1 106 1
CAMK1 106 13
IKK epsilon 106 3
Lck 106 11
CLK2 106 4
NUAK1 105 2
MLK1 105 6
PAK6 105 11
Src 105 11
CSK 104 1
BRK 104 4
MPSK1 104 2
PAK5 104 3
EPH-B3 104 0
AMPK 104 9
MKK2 104 10
PIM2 103 6
EPH-A2 103 8
TrkA 103 1
MKK6 102 5
MLK3 102 8
TAO1 102 11
PKC gamma 101 6
MNK1 101 3
MARK3 101 7
EPH-A4 100 4
STK33 100 0
TAK1 100 7
Aurora B 100 2
PIM1 100 0
PKB alpha 99 5
p38 beta MAPK 99 9
IRR 99 6
PHK 99 5
MAPKAP-K2 98 12
CDK2-Cyclin A 98 4
JNK1 98 6
ERK2 98 2
CAMKK beta 97 4
MKK1 97 16
PKC alpha 96 0
MST2 96 2
CHK1 96 1
TTK 95 4
p38 alpha MAPK 95 8
VEGFR1 95 2
RSK1 95 1
JNK3 93 6
MEKK1 93 8
DYRK3 93 6
LKB1 93 5
p38 gamma MAPK 93 4
EF2K 93 13
SRPK1 92 4
NEK6 92 4
HIPK1 92 6
CHK2 92 3
PAK4 91 4
IKK beta 91 1
MARK4 90 11
p38 delta MAPK 90 9
SmMLCK 90 2
PRAK 89 2
MARK2 89 5
CK1 delta 88 9
IGF-1R 87 12
RSK2 87 3
GCK 86 2
PKB beta 85 2
JNK2 85 6
GSK3 beta 83 8
SGK1 83 5
DYRK1A 83 4
ERK8 82 1
CK2 78 12
PRK2 78 4
IRAK4 72 6
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
DYRK2 124 3
PIM3 121 6
MAPKAP-K3 119 1
TIE2 118 3
HIPK1 112 6
HIPK3 112 2
PKD1 112 4
MARK1 112 17
BRSK1 111 0
FGF-R1 111 12
TrkA 110 9
PIM2 109 3
PKC gamma 109 8
S6K1 108 6
MLK1 108 6
BRSK2 108 1
TAO1 108 9
NUAK1 108 6
TAK1 108 4
PKC zeta 108 3
EPH-B1 108 7
PAK6 108 7
MARK3 107 7
HER4 107 20
ABL 106 11
PKA 106 2
MLK3 106 4
ZAP70 106 10
HIPK2 106 6
p38 beta MAPK 106 2
PDK1 106 2
SYK 105 6
EPH-B2 105 10
Aurora A 105 4
CLK2 104 12
MSK1 104 18
IR 103 20
BTK 103 5
JNK3 103 7
PAK2 103 1
NEK2a 103 2
MKK2 103 12
Aurora B 102 4
MKK1 102 5
CAMK1 101 11
DAPK1 101 11
EPH-A4 101 8
EPH-B4 101 8
CSK 101 15
STK33 100 11
EPH-B3 100 9
PAK5 100 8
Src 100 3
YES1 100 9
PRAK 99 12
MEKK1 99 4
MELK 99 7
ASK1 99 3
p38 delta MAPK 99 5
MKK6 98 4
JAK2 98 3
DYRK3 98 1
MPSK1 98 8
RSK1 98 4
MNK2 98 3
MARK2 97 9
ERK1 97 9
IKK beta 97 7
PKB alpha 97 8
AMPK 96 0
MST4 96 9
PIM1 95 11
SmMLCK 95 12
RIPK2 95 3
RSK2 95 1
MAPKAP-K2 95 6
IKK epsilon 95 6
IRR 94 3
JNK1 94 3
ROCK 2 94 5
PLK1 94 7
MINK1 93 11
BRK 93 8
CHK1 92 7
MNK1 92 16
Lck 92 8
EPH-A2 91 9
DYRK1A 91 6
TTK 91 4
PAK4 91 9
PKB beta 90 13
ERK2 90 9
JNK2 90 2
MST2 90 0
MARK4 89 8
SRPK1 89 3
LKB1 89 0
PKC alpha 88 5
GSK3 beta 88 3
SGK1 87 3
p38 alpha MAPK 87 13
CK1 delta 87 7
CK2 87 12
PHK 86 0
ERK8 86 1
NEK6 86 12
IGF-1R 86 2
CHK2 84 4
TBK1 82 39
CAMKK beta 81 15
VEGFR1 81 5
p38 gamma MAPK 80 11
CDK2-Cyclin A 79 7
EF2K 76 0
GCK 72 2
PRK2 70 1
IRAK4 66 0
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
MAPKAP-K3 123 7
EPH-B4 123 13
PDK1 122 9
DYRK2 119 7
ROCK 2 116 3
EPH-B1 115 18
PKD1 115 15
TIE2 113 4
PAK2 113 8
TAK1 111 2
MINK1 111 13
Src 111 13
YES1 109 2
ABL 109 10
MKK2 109 19
MLK3 109 12
NEK2a 108 7
MST4 108 13
BRSK2 108 7
EPH-B2 108 5
PKB alpha 107 24
PIM3 107 2
PKA 107 12
HIPK2 106 5
HER4 105 6
MARK3 105 0
MARK1 104 6
FGF-R1 104 1
BRK 104 2
DAPK1 103 18
BTK 103 15
PAK6 103 5
MNK2 102 14
HIPK3 102 3
PAK5 101 4
NUAK1 101 5
IKK beta 100 6
RIPK2 100 4
IRR 100 5
JAK2 100 10
S6K1 100 0
ERK2 100 5
MLK1 100 3
MPSK1 100 4
IR 99 2
MKK6 99 1
LKB1 98 4
MELK 98 14
JNK3 98 8
CSK 98 5
PIM2 97 2
MKK1 97 9
CLK2 97 11
BRSK1 97 1
EPH-A4 96 7
PKC gamma 96 1
PLK1 96 3
MSK1 95 1
PIM1 95 10
p38 beta MAPK 95 2
AMPK 94 6
HIPK1 94 18
MST2 94 7
ASK1 94 0
MNK1 93 1
Aurora B 93 0
TBK1 93 1
MARK4 93 10
IGF-1R 93 14
DYRK3 93 9
SYK 92 13
ZAP70 92 0
PKC zeta 92 5
Aurora A 92 15
EPH-A2 91 6
MAPKAP-K2 91 4
TAO1 91 6
SmMLCK 91 15
JNK1 90 21
PRAK 90 3
CAMKK beta 90 2
p38 delta MAPK 90 1
MEKK1 89 0
PKC alpha 89 5
CAMK1 89 5
STK33 89 16
JNK2 88 5
CDK2-Cyclin A 88 3
p38 gamma MAPK 87 5
PKB beta 86 2
CHK1 86 9
IKK epsilon 86 4
TTK 86 4
EPH-B3 86 0
TrkA 86 0
PAK4 85 5
ERK1 85 4
NEK6 84 9
DYRK1A 84 6
Lck 84 11
MARK2 83 6
CK2 83 2
SRPK1 83 9
VEGFR1 83 4
CHK2 82 8
RSK1 81 8
RSK2 81 11
CK1 delta 81 4
p38 alpha MAPK 80 9
SGK1 78 4
ERK8 77 0
PHK 76 0
GCK 71 9
GSK3 beta 71 2
EF2K 69 1
IRAK4 67 1
PRK2 58 1