Inhibitor | BML-258 (SK1-I)  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
PRK2	58	1
IRAK4	67	1
EF2K	69	1
GCK	71	9
GSK3 beta	71	2
PHK	76	0
ERK8	77	0
SGK1	78	4
p38 alpha MAPK	80	9
RSK1	81	8
RSK2	81	11
CK1 delta	81	4
CHK2	82	8
SRPK1	83	9
VEGFR1	83	4
MARK2	83	6
CK2	83	2
DYRK1A	84	6
Lck	84	11
NEK6	84	9
PAK4	85	5
ERK1	85	4
PKB beta	86	2
CHK1	86	9
IKK epsilon	86	4
TTK	86	4
EPH-B3	86	0
TrkA	86	0
p38 gamma MAPK	87	5
CDK2-Cyclin A	88	3
JNK2	88	5
PKC alpha	89	5
CAMK1	89	5
STK33	89	16
MEKK1	89	0
CAMKK beta	90	2
p38 delta MAPK	90	1
JNK1	90	21
PRAK	90	3
TAO1	91	6
SmMLCK	91	15
EPH-A2	91	6
MAPKAP-K2	91	4
PKC zeta	92	5
Aurora A	92	15
SYK	92	13
ZAP70	92	0
MARK4	93	10
IGF-1R	93	14
DYRK3	93	9
MNK1	93	1
Aurora B	93	0
TBK1	93	1
MST2	94	7
ASK1	94	0
AMPK	94	6
HIPK1	94	18
PIM1	95	10
p38 beta MAPK	95	2
MSK1	95	1
PKC gamma	96	1
PLK1	96	3
EPH-A4	96	7
BRSK1	97	1
PIM2	97	2
MKK1	97	9
CLK2	97	11
JNK3	98	8
CSK	98	5
LKB1	98	4
MELK	98	14
IR	99	2
MKK6	99	1
IKK beta	100	6
RIPK2	100	4
IRR	100	5
JAK2	100	10
S6K1	100	0
ERK2	100	5
MLK1	100	3
MPSK1	100	4
PAK5	101	4
NUAK1	101	5
MNK2	102	14
HIPK3	102	3
DAPK1	103	18
BTK	103	15
PAK6	103	5
FGF-R1	104	1
BRK	104	2
MARK1	104	6
MARK3	105	0
HER4	105	6
HIPK2	106	5
PKB alpha	107	24
PIM3	107	2
PKA	107	12
NEK2a	108	7
MST4	108	13
BRSK2	108	7
EPH-B2	108	5
YES1	109	2
ABL	109	10
MKK2	109	19
MLK3	109	12
TAK1	111	2
MINK1	111	13
Src	111	13
TIE2	113	4
PAK2	113	8
PKD1	115	15
EPH-B1	115	18
ROCK 2	116	3
DYRK2	119	7
PDK1	122	9
MAPKAP-K3	123	7
EPH-B4	123	13

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IRAK4	66	0
PRK2	70	1
GCK	72	2
EF2K	76	0
CDK2-Cyclin A	79	7
p38 gamma MAPK	80	11
CAMKK beta	81	15
VEGFR1	81	5
TBK1	82	39
CHK2	84	4
ERK8	86	1
NEK6	86	12
IGF-1R	86	2
PHK	86	0
SGK1	87	3
p38 alpha MAPK	87	13
CK1 delta	87	7
CK2	87	12
PKC alpha	88	5
GSK3 beta	88	3
LKB1	89	0
MARK4	89	8
SRPK1	89	3
MST2	90	0
PKB beta	90	13
ERK2	90	9
JNK2	90	2
PAK4	91	9
EPH-A2	91	9
DYRK1A	91	6
TTK	91	4
MNK1	92	16
Lck	92	8
CHK1	92	7
MINK1	93	11
BRK	93	8
IRR	94	3
JNK1	94	3
ROCK 2	94	5
PLK1	94	7
RSK2	95	1
MAPKAP-K2	95	6
IKK epsilon	95	6
PIM1	95	11
SmMLCK	95	12
RIPK2	95	3
AMPK	96	0
MST4	96	9
IKK beta	97	7
PKB alpha	97	8
MARK2	97	9
ERK1	97	9
DYRK3	98	1
MPSK1	98	8
RSK1	98	4
MNK2	98	3
MKK6	98	4
JAK2	98	3
PRAK	99	12
MEKK1	99	4
MELK	99	7
ASK1	99	3
p38 delta MAPK	99	5
EPH-B3	100	9
PAK5	100	8
Src	100	3
YES1	100	9
STK33	100	11
EPH-B4	101	8
CSK	101	15
CAMK1	101	11
DAPK1	101	11
EPH-A4	101	8
Aurora B	102	4
MKK1	102	5
NEK2a	103	2
MKK2	103	12
IR	103	20
BTK	103	5
JNK3	103	7
PAK2	103	1
MSK1	104	18
CLK2	104	12
Aurora A	105	4
SYK	105	6
EPH-B2	105	10
PDK1	106	2
ABL	106	11
PKA	106	2
MLK3	106	4
ZAP70	106	10
HIPK2	106	6
p38 beta MAPK	106	2
HER4	107	20
MARK3	107	7
PAK6	108	7
S6K1	108	6
MLK1	108	6
BRSK2	108	1
TAO1	108	9
NUAK1	108	6
TAK1	108	4
PKC zeta	108	3
EPH-B1	108	7
PIM2	109	3
PKC gamma	109	8
TrkA	110	9
FGF-R1	111	12
BRSK1	111	0
MARK1	112	17
HIPK1	112	6
HIPK3	112	2
PKD1	112	4
TIE2	118	3
MAPKAP-K3	119	1
PIM3	121	6
DYRK2	124	3

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IRAK4	72	6
CK2	78	12
PRK2	78	4
ERK8	82	1
DYRK1A	83	4
GSK3 beta	83	8
SGK1	83	5
JNK2	85	6
PKB beta	85	2
GCK	86	2
RSK2	87	3
IGF-1R	87	12
CK1 delta	88	9
PRAK	89	2
MARK2	89	5
MARK4	90	11
p38 delta MAPK	90	9
SmMLCK	90	2
PAK4	91	4
IKK beta	91	1
CHK2	92	3
SRPK1	92	4
NEK6	92	4
HIPK1	92	6
JNK3	93	6
MEKK1	93	8
DYRK3	93	6
LKB1	93	5
p38 gamma MAPK	93	4
EF2K	93	13
RSK1	95	1
TTK	95	4
p38 alpha MAPK	95	8
VEGFR1	95	2
CHK1	96	1
PKC alpha	96	0
MST2	96	2
CAMKK beta	97	4
MKK1	97	16
ERK2	98	2
MAPKAP-K2	98	12
CDK2-Cyclin A	98	4
JNK1	98	6
PHK	99	5
PKB alpha	99	5
p38 beta MAPK	99	9
IRR	99	6
TAK1	100	7
Aurora B	100	2
PIM1	100	0
EPH-A4	100	4
STK33	100	0
MNK1	101	3
MARK3	101	7
PKC gamma	101	6
MKK6	102	5
MLK3	102	8
TAO1	102	11
PIM2	103	6
EPH-A2	103	8
TrkA	103	1
AMPK	104	9
MKK2	104	10
CSK	104	1
BRK	104	4
MPSK1	104	2
PAK5	104	3
EPH-B3	104	0
NUAK1	105	2
MLK1	105	6
PAK6	105	11
Src	105	11
IKK epsilon	106	3
Lck	106	11
CLK2	106	4
PKC zeta	106	2
PLK1	106	1
CAMK1	106	13
MINK1	107	14
PDK1	107	4
IR	107	7
PKD1	107	4
BTK	107	25
HIPK2	108	8
MELK	108	2
ERK1	108	23
DAPK1	109	7
ROCK 2	110	1
ABL	110	3
NEK2a	110	3
PKA	110	2
MSK1	110	6
TBK1	111	13
MNK2	111	3
PAK2	113	2
MARK1	114	12
BRSK1	114	4
S6K1	114	8
FGF-R1	115	6
MAPKAP-K3	115	13
EPH-B2	115	5
ASK1	115	8
MST4	116	7
ZAP70	116	2
DYRK2	116	3
Aurora A	116	3
HIPK3	118	13
PIM3	118	4
JAK2	118	14
RIPK2	119	8
EPH-B4	122	7
YES1	123	1
EPH-B1	126	14
HER4	127	6
BRSK2	130	7
SYK	134	4
TIE2	141	5