Inhibitor | MLN4924  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CHK2	67	4
ERK1	73	4
IKK epsilon	78	2
PIM3	78	14
YES1	79	3
PKA	81	8
ROCK 2	81	12
JNK3	82	10
IRR	83	8
CK1 delta	84	1
DYRK3	84	10
MST2	84	8
S6K1	85	12
BRSK2	86	13
ASK1	87	7
IGF-1R	88	11
MST4	88	10
JNK2	88	2
PKC alpha	88	3
CK2	88	11
GCK	88	5
MLK1	88	1
MARK2	88	1
TBK1	88	4
PKB beta	88	5
ERK2	89	7
HIPK3	89	6
PAK5	89	10
CDK2-Cyclin A	90	6
p38 delta MAPK	90	4
MELK	91	6
PAK6	91	16
PRK2	92	13
DYRK2	92	16
TrkA	92	1
MNK1	92	11
MLK3	92	12
IR	93	5
PAK2	93	4
Aurora B	93	7
MAPKAP-K2	93	3
JAK2	93	10
PDK1	94	7
MKK6	94	10
PLK1	95	5
p38 gamma MAPK	95	5
RSK1	95	12
NUAK1	96	4
PKC zeta	96	16
MINK1	96	7
IKK beta	96	1
RSK2	96	2
JNK1	97	1
HIPK2	97	10
PKD1	97	6
Aurora A	97	5
CHK1	98	6
HIPK1	98	29
GSK3 beta	98	8
p38 beta MAPK	98	14
TTK	98	1
IRAK4	99	4
AMPK	99	7
PRAK	99	30
MKK1	99	7
MKK2	99	2
EPH-B1	100	11
NEK2a	100	5
MARK3	100	15
TAO1	100	12
MAPKAP-K3	101	8
PIM2	101	5
SRPK1	102	7
p38 alpha MAPK	102	16
NEK6	102	12
CSK	103	24
DYRK1A	103	1
PIM1	103	18
MARK4	103	0
VEGFR1	104	5
ERK8	104	20
LKB1	104	3
SYK	104	6
EPH-A4	105	3
TAK1	105	8
BTK	105	6
EPH-A2	105	18
PHK	106	10
PAK4	106	8
EF2K	107	9
MEKK1	107	5
MARK1	107	8
MNK2	108	4
EPH-B4	108	5
CAMKK beta	108	6
EPH-B2	109	6
Lck	110	8
MSK1	110	14
CAMK1	110	5
SGK1	112	7
Src	113	15
DAPK1	113	15
HER4	116	4
SmMLCK	118	21
CLK2	119	22
PKB alpha	119	15
RIPK2	121	5
FGF-R1	126	1
EPH-B3	129	10
BRSK1	129	54

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CHK2	71	24
PKA	73	14
IKK epsilon	73	14
ERK1	77	12
CSK	78	14
CK2	80	8
JNK3	81	10
MLK1	82	3
MST4	83	19
JNK2	83	16
HIPK3	84	16
CDK2-Cyclin A	84	3
JNK1	84	13
CK1 delta	86	5
TTK	86	1
ASK1	87	8
DYRK3	87	29
MST2	87	2
IRR	87	18
PIM1	87	20
MELK	87	16
HIPK2	88	0
Aurora B	88	24
MAPKAP-K2	88	10
PIM3	88	41
PKC alpha	88	20
PRAK	89	22
PAK5	89	20
IR	89	8
JAK2	89	11
VEGFR1	89	11
BRSK1	89	13
PKD1	90	17
PRK2	90	1
MARK2	90	9
SmMLCK	91	34
GCK	91	13
CHK1	91	13
EPH-A4	92	21
p38 delta MAPK	92	11
BRSK2	92	11
SRPK1	92	15
SYK	92	18
MLK3	92	1
GSK3 beta	93	9
PLK1	93	7
DYRK2	93	17
YES1	93	43
MARK4	93	15
MINK1	93	13
PKB beta	93	22
S6K1	94	16
PAK6	94	17
IGF-1R	94	6
PDK1	94	11
PIM2	94	20
SGK1	95	11
NEK6	95	26
MKK1	95	13
p38 beta MAPK	95	14
MKK6	95	0
CAMKK beta	96	10
DYRK1A	96	14
IRAK4	96	22
RSK1	96	2
AMPK	96	19
ROCK 2	97	24
TBK1	97	22
NUAK1	98	9
HIPK1	98	14
PAK2	98	14
Lck	98	10
TrkA	99	39
RSK2	100	3
IKK beta	100	3
MARK1	100	3
p38 alpha MAPK	100	24
EF2K	100	15
PAK4	101	11
MARK3	101	11
MEKK1	101	26
p38 gamma MAPK	101	19
EPH-B1	102	28
MSK1	103	9
Aurora A	103	3
MAPKAP-K3	103	13
TAO1	104	7
MKK2	104	6
ERK8	104	21
MNK1	104	7
EPH-B4	106	4
BTK	106	27
ERK2	106	28
EPH-B2	107	3
TAK1	107	3
RIPK2	107	13
NEK2a	109	4
PHK	109	8
HER4	110	5
DAPK1	110	12
EPH-A2	113	20
CAMK1	114	3
MNK2	114	23
PKC zeta	115	27
PKB alpha	118	2
Src	125	27
CLK2	127	3
LKB1	127	13
EPH-B3	132	35
FGF-R1	138	22