Inhibitor | IMD-0354  

Screen Conc: 1.00µM

Kinase Sort ascending	% Activity Remaining	Standard Deviation
YES1	92	5
VEGFR1	107	17
TTK	97	5
TrkA	130	33
TBK1	100	7
TAK1	117	1
SYK	109	25
SRPK1	72	0
Src	101	14
SmMLCK	104	3
SGK1	170	1
S6K1	171	4
RSK2	116	4
RSK1	156	9
ROCK 2	111	1
RIPK2	110	7
PRK2	116	2
PRAK	65	4
PLK1	116	0
PKD1	109	15
PKC zeta	114	3
PKC alpha	95	14
PKB beta	93	3
PKB alpha	130	21
PKA	99	5
PIM3	105	7
PIM2	131	7
PIM1	109	12
PHK	113	10
PDK1	97	11
PAK6	119	7
PAK5	104	6
PAK4	96	2
PAK2	80	5
p38 gamma MAPK	140	19
p38 delta MAPK	112	1
p38 beta MAPK	104	25
p38 alpha MAPK	112	4
NUAK1	100	5
NEK6	141	8
NEK2a	113	15
MST4	108	4
MST2	98	4
MSK1	150	12
MNK2	95	11
MNK1	116	6
MLK3	115	1
MLK1	112	5
MKK1	111	14
MINK1	134	12
MELK	104	3
MEKK1	105	1
MARK4	105	11
MARK3	97	1
MARK2	94	3
MARK1	105	11
MAPKAP-K3	91	23
MAPKAP-K2	97	6
LKB1	113	0
Lck	114	8
JNK3	111	6
JNK2	112	3
JNK1	107	3
JAK2	98	3
IRR	106	3
IRAK4	109	0
IR	89	5
IKK epsilon	99	5
IKK beta	90	16
IGF-1R	94	15
HIPK3	101	6
HIPK2	136	14
HIPK1	128	2
HER4	110	8
GSK3 beta	121	0
GCK	108	6
FGF-R1	118	10
ERK8	107	9
ERK2	109	8
ERK1	117	18
EPH-B4	119	14
EPH-B3	121	0
EPH-A4	120	4
EPH-A2	113	3
EF2K	119	4
DYRK3	75	10
DYRK2	104	1
DYRK1A	84	3
CSK	116	17
CK2	113	4
CK1 delta	99	1
CHK2	108	6
CHK1	120	10
CDK2-Cyclin A	118	4
CAMKK beta	109	4
CAMK1	105	11
BTK	123	2
BRSK2	105	3
BRSK1	120	17
Aurora B	118	15
Aurora A	107	14
AMPK	111	13

Screen Conc: 10.00µM

Kinase Sort ascending	% Activity Remaining	Standard Deviation
YES1	73	10
VEGFR1	71	13
TTK	75	13
TrkA	81	2
TBK1	69	15
TAK1	61	4
SYK	73	2
SRPK1	47	1
Src	60	14
SmMLCK	64	4
SGK1	256	1
S6K1	125	16
RSK2	61	3
RSK1	119	4
ROCK 2	90	6
RIPK2	106	11
PRK2	105	5
PRAK	49	10
PLK1	92	11
PKD1	98	6
PKC zeta	97	2
PKC alpha	95	11
PKB beta	55	5
PKB alpha	125	76
PKA	56	9
PIM3	63	7
PIM2	123	27
PIM1	60	21
PHK	84	8
PDK1	80	1
PAK6	126	5
PAK5	84	2
PAK4	89	1
PAK2	65	1
p38 gamma MAPK	127	8
p38 delta MAPK	107	16
p38 beta MAPK	87	10
p38 alpha MAPK	99	6
NUAK1	60	9
NEK6	105	9
NEK2a	166	4
MST4	82	5
MST2	106	4
MSK1	107	17
MNK2	94	5
MNK1	90	14
MLK3	98	5
MLK1	89	2
MKK1	70	9
MINK1	130	10
MELK	66	14
MEKK1	102	8
MARK4	87	1
MARK3	72	6
MARK2	80	3
MARK1	82	2
MAPKAP-K3	71	3
MAPKAP-K2	72	5
LKB1	95	0
Lck	101	6
JNK3	88	5
JNK2	87	3
JNK1	92	0
JAK2	81	7
IRR	110	6
IRAK4	109	0
IR	94	8
IKK epsilon	67	10
IKK beta	87	17
IGF-1R	94	0
HIPK3	100	10
HIPK2	109	12
HIPK1	106	5
HER4	94	16
GSK3 beta	104	11
GCK	99	1
FGF-R1	108	7
ERK8	54	26
ERK2	106	6
ERK1	111	6
EPH-B4	130	5
EPH-B3	117	3
EPH-A4	94	9
EPH-A2	89	0
EF2K	110	7
DYRK3	55	12
DYRK2	85	9
DYRK1A	51	3
CSK	76	4
CK2	97	19
CK1 delta	104	16
CHK2	112	1
CHK1	161	15
CDK2-Cyclin A	97	0
CAMKK beta	101	0
CAMK1	111	9
BTK	88	2
BRSK2	95	8
BRSK1	89	4
Aurora B	123	9
Aurora A	74	1
AMPK	84	2