Inhibitor | IMD-0354  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
SRPK1	47	1
PRAK	49	10
DYRK1A	51	3
ERK8	54	26
DYRK3	55	12
PKB beta	55	5
PKA	56	9
NUAK1	60	9
Src	60	14
PIM1	60	21
TAK1	61	4
RSK2	61	3
PIM3	63	7
SmMLCK	64	4
PAK2	65	1
MELK	66	14
IKK epsilon	67	10
TBK1	69	15
MKK1	70	9
VEGFR1	71	13
MAPKAP-K3	71	3
MAPKAP-K2	72	5
MARK3	72	6
YES1	73	10
SYK	73	2
Aurora A	74	1
TTK	75	13
CSK	76	4
PDK1	80	1
MARK2	80	3
TrkA	81	2
JAK2	81	7
MST4	82	5
MARK1	82	2
PHK	84	8
PAK5	84	2
AMPK	84	2
DYRK2	85	9
JNK2	87	3
p38 beta MAPK	87	10
IKK beta	87	17
MARK4	87	1
JNK3	88	5
BTK	88	2
PAK4	89	1
EPH-A2	89	0
MLK1	89	2
BRSK1	89	4
MNK1	90	14
ROCK 2	90	6
PLK1	92	11
JNK1	92	0
HER4	94	16
IGF-1R	94	0
IR	94	8
MNK2	94	5
EPH-A4	94	9
BRSK2	95	8
PKC alpha	95	11
LKB1	95	0
PKC zeta	97	2
CK2	97	19
CDK2-Cyclin A	97	0
PKD1	98	6
MLK3	98	5
p38 alpha MAPK	99	6
GCK	99	1
HIPK3	100	10
Lck	101	6
CAMKK beta	101	0
MEKK1	102	8
CK1 delta	104	16
GSK3 beta	104	11
PRK2	105	5
NEK6	105	9
HIPK1	106	5
RIPK2	106	11
MST2	106	4
ERK2	106	6
p38 delta MAPK	107	16
MSK1	107	17
FGF-R1	108	7
IRAK4	109	0
HIPK2	109	12
EF2K	110	7
IRR	110	6
ERK1	111	6
CAMK1	111	9
CHK2	112	1
EPH-B3	117	3
RSK1	119	4
Aurora B	123	9
PIM2	123	27
PKB alpha	125	76
S6K1	125	16
PAK6	126	5
p38 gamma MAPK	127	8
MINK1	130	10
EPH-B4	130	5
CHK1	161	15
NEK2a	166	4
SGK1	256	1

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
PRAK	65	4
SRPK1	72	0
DYRK3	75	10
PAK2	80	5
DYRK1A	84	3
IR	89	5
IKK beta	90	16
MAPKAP-K3	91	23
YES1	92	5
PKB beta	93	3
MARK2	94	3
IGF-1R	94	15
MNK2	95	11
PKC alpha	95	14
PAK4	96	2
MAPKAP-K2	97	6
PDK1	97	11
MARK3	97	1
TTK	97	5
MST2	98	4
JAK2	98	3
IKK epsilon	99	5
PKA	99	5
CK1 delta	99	1
TBK1	100	7
NUAK1	100	5
HIPK3	101	6
Src	101	14
SmMLCK	104	3
MELK	104	3
DYRK2	104	1
p38 beta MAPK	104	25
PAK5	104	6
MARK1	105	11
MEKK1	105	1
MARK4	105	11
CAMK1	105	11
PIM3	105	7
BRSK2	105	3
IRR	106	3
ERK8	107	9
JNK1	107	3
VEGFR1	107	17
Aurora A	107	14
MST4	108	4
GCK	108	6
CHK2	108	6
SYK	109	25
PIM1	109	12
CAMKK beta	109	4
IRAK4	109	0
ERK2	109	8
PKD1	109	15
HER4	110	8
RIPK2	110	7
AMPK	111	13
MKK1	111	14
ROCK 2	111	1
JNK3	111	6
MLK1	112	5
JNK2	112	3
p38 alpha MAPK	112	4
p38 delta MAPK	112	1
EPH-A2	113	3
PHK	113	10
CK2	113	4
NEK2a	113	15
LKB1	113	0
Lck	114	8
PKC zeta	114	3
MLK3	115	1
RSK2	116	4
PRK2	116	2
PLK1	116	0
CSK	116	17
MNK1	116	6
TAK1	117	1
ERK1	117	18
FGF-R1	118	10
CDK2-Cyclin A	118	4
Aurora B	118	15
EPH-B4	119	14
EF2K	119	4
PAK6	119	7
EPH-A4	120	4
BRSK1	120	17
CHK1	120	10
EPH-B3	121	0
GSK3 beta	121	0
BTK	123	2
HIPK1	128	2
PKB alpha	130	21
TrkA	130	33
PIM2	131	7
MINK1	134	12
HIPK2	136	14
p38 gamma MAPK	140	19
NEK6	141	8
MSK1	150	12
RSK1	156	9
SGK1	170	1
S6K1	171	4