Inhibitor | Cot-Tpl2 Inhibitor Compound 10b (Abbott)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Cot-Tpl2 Inhibitor Compound 10b (Abbott)   C20H15N3OS 345.42 Cot-Tpl2 Cusack K. (2009) Bioorganic and MedicinalChemistry Letters 19 1722-1725

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
CLK2
2
 0
TAK1
2
 0
MINK1
4
 0
GSK3 beta
4
 0
MLK3
4
 0
GCK
5
 2
DYRK1A
5
 1
NUAK1
6
 0
ERK2
6
 0
MLK1
6
 1
ROCK 2
7
 0
PAK4
7
 0
HIPK2
9
 4
DAPK1
10
 3
PKD1 11 1
RIPK2 12 1
HIPK1 13 4
IGF-1R 13 1
YES1 13 4
PRAK 15 6
JNK1 15 1
MELK 15 1
IRR 16 2
ERK1 16 1
PAK5 16 0
HER4 17 1
MKK1 17 2
SmMLCK 17 1
SRPK1 17 1
CK1 delta 18 3
IR 18 4
CHK2 18 10
PKC alpha 18 2
HIPK3 19 2
EPH-B4 19 2
MST2 21 3
VEGFR1 22 1
ERK8 23 1
LKB1 23 2
TTK 24 1
EPH-B2 24 1
MARK3 26 3
MARK2 28 2
TrkA 28 4
CHK1 29 1
PRK2 29 9
CAMKK beta 30 3
MEKK1 30 0
BTK 30 11
RSK1 31 3
IKK epsilon 31 1
PAK6 31 1
JNK2 33 0
MST4 35 0
CDK2-Cyclin A 35 1
p38 delta MAPK 36 1
MARK1 37 6
CAMK1 38 1
p38 gamma MAPK 38 0
S6K1 39 0
PIM1 41 4
PIM3 42 4
Aurora B 43 1
JAK2 43 6
IRAK4 44 10
NEK2a 44 3
SGK1 46 2
MARK4 46 2
JNK3 46 8
TBK1 47 7
RSK2 53 0
PHK 55 1
SYK 56 2
CSK 58 2
DYRK3 59 5
p38 alpha MAPK 59 4
IKK beta 65 2
MNK2 66 6
Lck 67 9
AMPK 68 3
MAPKAP-K3 69 2
MSK1 70 9
EPH-A4 71 9
p38 beta MAPK 80 5
PIM2 81 4
PKC zeta 82 3
PAK2 84 3
FGF-R1 85 6
EPH-A2 86 4
DYRK2 88 5
BRSK1 89 8
Aurora A 89 2
EPH-B3 92 5
MAPKAP-K2 94 8
PKA 96 3
PLK1 97 5
PKB beta 98 4
MNK1 99 4
PDK1 100 12
CK2 100 12
PKB alpha 108 4
Src 108 7
EF2K 117 10
BRSK2 130 3
NEK6 135 13
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
GCK
6
 1
TAK1
8
 0
CLK2
10
 0
MINK1 12 0
GSK3 beta 16 6
PAK4 18 1
MLK1 18 1
MLK3 19 0
DYRK1A 21 1
PKD1 21 3
HIPK2 22 2
NUAK1 24 5
IRR 26 2
ROCK 2 31 5
ERK2 35 4
RIPK2 36 3
HIPK1 37 2
CHK2 37 3
PAK5 37 3
DAPK1 40 2
HER4 40 5
PRAK 42 8
ERK8 50 10
HIPK3 52 8
SmMLCK 53 0
TTK 55 4
VEGFR1 55 10
MELK 57 7
LKB1 57 7
SGK1 58 4
ERK1 58 8
MST2 59 2
CAMKK beta 61 5
CHK1 64 2
PKC alpha 64 12
RSK1 65 3
MARK2 65 4
YES1 66 4
MARK1 66 5
SRPK1 67 12
JNK1 69 0
MARK3 69 1
PAK6 70 10
CK1 delta 73 1
TrkA 73 14
MEKK1 73 3
NEK2a 74 6
EPH-B2 74 2
MST4 75 2
PRK2 76 1
p38 gamma MAPK 76 5
DYRK3 76 1
EPH-B4 76 13
DYRK2 77 5
p38 delta MAPK 77 6
EPH-A2 78 12
IR 81 1
IKK beta 81 11
BRSK1 81 0
JNK2 82 6
CSK 82 13
MARK4 82 5
RSK2 84 12
MAPKAP-K3 84 2
IKK epsilon 86 3
MKK1 86 8
IGF-1R 87 2
CDK2-Cyclin A 87 10
Lck 88 4
SYK 88 5
PKB beta 88 2
PIM3 88 0
Src 89 4
PIM1 89 2
EPH-A4 89 3
JAK2 90 11
CAMK1 90 12
S6K1 90 11
MNK2 91 7
TBK1 91 9
IRAK4 92 7
PHK 92 3
PKC zeta 93 3
PAK2 93 7
CK2 94 0
BTK 94 10
AMPK 95 5
PIM2 95 13
FGF-R1 96 2
Aurora B 96 5
MSK1 97 10
PLK1 98 8
NEK6 98 2
Aurora A 99 9
p38 alpha MAPK 101 17
MAPKAP-K2 101 5
PKA 103 11
PKB alpha 104 4
PDK1 107 3
BRSK2 108 7
p38 beta MAPK 111 10
JNK3 112 43
EPH-B3 113 1
EF2K 114 13
MNK1 114 9
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
GCK
7
 1
CLK2 50 4
MLK1 54 3
MINK1 58 5
HIPK2 64 2
PAK4 65 5
PKD1 66 7
IRR 66 8
GSK3 beta 68 6
TAK1 71 36
DYRK1A 72 4
MLK3 74 5
ROCK 2 75 10
DAPK1 76 8
HIPK3 76 14
MARK1 78 15
PAK5 79 4
PKA 80 16
ERK2 81 4
NUAK1 81 6
p38 delta MAPK 83 1
PAK6 85 2
HIPK1 86 4
RIPK2 86 14
SRPK1 87 10
EPH-A2 87 15
TTK 87 11
PRAK 87 9
MARK4 88 5
NEK2a 88 12
EPH-B2 90 5
MKK1 90 10
MSK1 90 32
CSK 90 3
CK2 91 1
SGK1 92 16
RSK1 92 2
TrkA 92 5
EPH-A4 93 16
p38 gamma MAPK 93 9
MAPKAP-K3 93 3
PKB beta 94 1
PKC alpha 94 9
Aurora A 95 0
SYK 96 2
p38 beta MAPK 96 5
IKK beta 96 3
CDK2-Cyclin A 97 11
DYRK3 97 0
JNK3 97 14
SmMLCK 98 4
TBK1 98 5
PIM2 98 3
CAMKK beta 99 0
ERK8 99 6
MELK 99 13
AMPK 99 1
Src 100 11
CHK1 100 12
PAK2 100 5
VEGFR1 100 8
PRK2 100 1
JAK2 101 2
PIM3 101 4
DYRK2 101 4
MST4 102 12
BRSK1 102 1
MAPKAP-K2 102 9
IR 103 1
MARK2 103 4
MARK3 104 4
FGF-R1 104 2
PHK 104 5
HER4 104 25
CHK2 104 6
PKB alpha 105 9
LKB1 105 5
Lck 105 9
CAMK1 107 9
EPH-B4 107 13
MNK1 107 12
JNK2 107 12
MST2 108 13
PKC zeta 108 3
PLK1 108 3
MEKK1 108 3
NEK6 108 4
RSK2 108 6
BRSK2 109 7
MNK2 109 26
IKK epsilon 109 2
CK1 delta 109 3
p38 alpha MAPK 110 5
Aurora B 110 1
PDK1 110 3
JNK1 111 1
S6K1 112 3
PIM1 112 1
IGF-1R 113 2
ERK1 114 20
YES1 115 22
BTK 120 33
EF2K 124 18
IRAK4 127 9
EPH-B3 128 4