Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Cot-Tpl2 Inhibitor Compound 10b (Abbott) | C20H15N3OS | 345.42 | Cot-Tpl2 | Cusack K. (2009) Bioorganic and MedicinalChemistry Letters 19 1722-1725 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 99 | 1 |
Aurora A | 95 | 0 |
Aurora B | 110 | 1 |
BRSK1 | 102 | 1 |
BRSK2 | 109 | 7 |
BTK | 120 | 33 |
CAMK1 | 107 | 9 |
CAMKK beta | 99 | 0 |
CDK2-Cyclin A | 97 | 11 |
CHK1 | 100 | 12 |
CHK2 | 104 | 6 |
CK1 delta | 109 | 3 |
CK2 | 91 | 1 |
CLK2 | 50 | 4 |
CSK | 90 | 3 |
DAPK1 | 76 | 8 |
DYRK1A | 72 | 4 |
DYRK2 | 101 | 4 |
DYRK3 | 97 | 0 |
EF2K | 124 | 18 |
EPH-A2 | 87 | 15 |
EPH-A4 | 93 | 16 |
EPH-B2 | 90 | 5 |
EPH-B3 | 128 | 4 |
EPH-B4 | 107 | 13 |
ERK1 | 114 | 20 |
ERK2 | 81 | 4 |
ERK8 | 99 | 6 |
FGF-R1 | 104 | 2 |
GCK |
7
|
1 |
GSK3 beta | 68 | 6 |
HER4 | 104 | 25 |
HIPK1 | 86 | 4 |
HIPK2 | 64 | 2 |
HIPK3 | 76 | 14 |
IGF-1R | 113 | 2 |
IKK beta | 96 | 3 |
IKK epsilon | 109 | 2 |
IR | 103 | 1 |
IRAK4 | 127 | 9 |
IRR | 66 | 8 |
JAK2 | 101 | 2 |
JNK1 | 111 | 1 |
JNK2 | 107 | 12 |
JNK3 | 97 | 14 |
Lck | 105 | 9 |
LKB1 | 105 | 5 |
MAPKAP-K2 | 102 | 9 |
MAPKAP-K3 | 93 | 3 |
MARK1 | 78 | 15 |
MARK2 | 103 | 4 |
MARK3 | 104 | 4 |
MARK4 | 88 | 5 |
MEKK1 | 108 | 3 |
MELK | 99 | 13 |
MINK1 | 58 | 5 |
MKK1 | 90 | 10 |
MLK1 | 54 | 3 |
MLK3 | 74 | 5 |
MNK1 | 107 | 12 |
MNK2 | 109 | 26 |
MSK1 | 90 | 32 |
MST2 | 108 | 13 |
MST4 | 102 | 12 |
NEK2a | 88 | 12 |
NEK6 | 108 | 4 |
NUAK1 | 81 | 6 |
p38 alpha MAPK | 110 | 5 |
p38 beta MAPK | 96 | 5 |
p38 delta MAPK | 83 | 1 |
p38 gamma MAPK | 93 | 9 |
PAK2 | 100 | 5 |
PAK4 | 65 | 5 |
PAK5 | 79 | 4 |
PAK6 | 85 | 2 |
PDK1 | 110 | 3 |
PHK | 104 | 5 |
PIM1 | 112 | 1 |
PIM2 | 98 | 3 |
PIM3 | 101 | 4 |
PKA | 80 | 16 |
PKB alpha | 105 | 9 |
PKB beta | 94 | 1 |
PKC alpha | 94 | 9 |
PKC zeta | 108 | 3 |
PKD1 | 66 | 7 |
PLK1 | 108 | 3 |
PRAK | 87 | 9 |
PRK2 | 100 | 1 |
RIPK2 | 86 | 14 |
ROCK 2 | 75 | 10 |
RSK1 | 92 | 2 |
RSK2 | 108 | 6 |
S6K1 | 112 | 3 |
SGK1 | 92 | 16 |
SmMLCK | 98 | 4 |
Src | 100 | 11 |
SRPK1 | 87 | 10 |
SYK | 96 | 2 |
TAK1 | 71 | 36 |
TBK1 | 98 | 5 |
TrkA | 92 | 5 |
TTK | 87 | 11 |
VEGFR1 | 100 | 8 |
YES1 | 115 | 22 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 95 | 5 |
Aurora A | 99 | 9 |
Aurora B | 96 | 5 |
BRSK1 | 81 | 0 |
BRSK2 | 108 | 7 |
BTK | 94 | 10 |
CAMK1 | 90 | 12 |
CAMKK beta | 61 | 5 |
CDK2-Cyclin A | 87 | 10 |
CHK1 | 64 | 2 |
CHK2 | 37 | 3 |
CK1 delta | 73 | 1 |
CK2 | 94 | 0 |
CLK2 |
10
|
0 |
CSK | 82 | 13 |
DAPK1 | 40 | 2 |
DYRK1A | 21 | 1 |
DYRK2 | 77 | 5 |
DYRK3 | 76 | 1 |
EF2K | 114 | 13 |
EPH-A2 | 78 | 12 |
EPH-A4 | 89 | 3 |
EPH-B2 | 74 | 2 |
EPH-B3 | 113 | 1 |
EPH-B4 | 76 | 13 |
ERK1 | 58 | 8 |
ERK2 | 35 | 4 |
ERK8 | 50 | 10 |
FGF-R1 | 96 | 2 |
GCK |
6
|
1 |
GSK3 beta | 16 | 6 |
HER4 | 40 | 5 |
HIPK1 | 37 | 2 |
HIPK2 | 22 | 2 |
HIPK3 | 52 | 8 |
IGF-1R | 87 | 2 |
IKK beta | 81 | 11 |
IKK epsilon | 86 | 3 |
IR | 81 | 1 |
IRAK4 | 92 | 7 |
IRR | 26 | 2 |
JAK2 | 90 | 11 |
JNK1 | 69 | 0 |
JNK2 | 82 | 6 |
JNK3 | 112 | 43 |
Lck | 88 | 4 |
LKB1 | 57 | 7 |
MAPKAP-K2 | 101 | 5 |
MAPKAP-K3 | 84 | 2 |
MARK1 | 66 | 5 |
MARK2 | 65 | 4 |
MARK3 | 69 | 1 |
MARK4 | 82 | 5 |
MEKK1 | 73 | 3 |
MELK | 57 | 7 |
MINK1 | 12 | 0 |
MKK1 | 86 | 8 |
MLK1 | 18 | 1 |
MLK3 | 19 | 0 |
MNK1 | 114 | 9 |
MNK2 | 91 | 7 |
MSK1 | 97 | 10 |
MST2 | 59 | 2 |
MST4 | 75 | 2 |
NEK2a | 74 | 6 |
NEK6 | 98 | 2 |
NUAK1 | 24 | 5 |
p38 alpha MAPK | 101 | 17 |
p38 beta MAPK | 111 | 10 |
p38 delta MAPK | 77 | 6 |
p38 gamma MAPK | 76 | 5 |
PAK2 | 93 | 7 |
PAK4 | 18 | 1 |
PAK5 | 37 | 3 |
PAK6 | 70 | 10 |
PDK1 | 107 | 3 |
PHK | 92 | 3 |
PIM1 | 89 | 2 |
PIM2 | 95 | 13 |
PIM3 | 88 | 0 |
PKA | 103 | 11 |
PKB alpha | 104 | 4 |
PKB beta | 88 | 2 |
PKC alpha | 64 | 12 |
PKC zeta | 93 | 3 |
PKD1 | 21 | 3 |
PLK1 | 98 | 8 |
PRAK | 42 | 8 |
PRK2 | 76 | 1 |
RIPK2 | 36 | 3 |
ROCK 2 | 31 | 5 |
RSK1 | 65 | 3 |
RSK2 | 84 | 12 |
S6K1 | 90 | 11 |
SGK1 | 58 | 4 |
SmMLCK | 53 | 0 |
Src | 89 | 4 |
SRPK1 | 67 | 12 |
SYK | 88 | 5 |
TAK1 |
8
|
0 |
TBK1 | 91 | 9 |
TrkA | 73 | 14 |
TTK | 55 | 4 |
VEGFR1 | 55 | 10 |
YES1 | 66 | 4 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 68 | 3 |
Aurora A | 89 | 2 |
Aurora B | 43 | 1 |
BRSK1 | 89 | 8 |
BRSK2 | 130 | 3 |
BTK | 30 | 11 |
CAMK1 | 38 | 1 |
CAMKK beta | 30 | 3 |
CDK2-Cyclin A | 35 | 1 |
CHK1 | 29 | 1 |
CHK2 | 18 | 10 |
CK1 delta | 18 | 3 |
CK2 | 100 | 12 |
CLK2 |
2
|
0 |
CSK | 58 | 2 |
DAPK1 |
10
|
3 |
DYRK1A |
5
|
1 |
DYRK2 | 88 | 5 |
DYRK3 | 59 | 5 |
EF2K | 117 | 10 |
EPH-A2 | 86 | 4 |
EPH-A4 | 71 | 9 |
EPH-B2 | 24 | 1 |
EPH-B3 | 92 | 5 |
EPH-B4 | 19 | 2 |
ERK1 | 16 | 1 |
ERK2 |
6
|
0 |
ERK8 | 23 | 1 |
FGF-R1 | 85 | 6 |
GCK |
5
|
2 |
GSK3 beta |
4
|
0 |
HER4 | 17 | 1 |
HIPK1 | 13 | 4 |
HIPK2 |
9
|
4 |
HIPK3 | 19 | 2 |
IGF-1R | 13 | 1 |
IKK beta | 65 | 2 |
IKK epsilon | 31 | 1 |
IR | 18 | 4 |
IRAK4 | 44 | 10 |
IRR | 16 | 2 |
JAK2 | 43 | 6 |
JNK1 | 15 | 1 |
JNK2 | 33 | 0 |
JNK3 | 46 | 8 |
Lck | 67 | 9 |
LKB1 | 23 | 2 |
MAPKAP-K2 | 94 | 8 |
MAPKAP-K3 | 69 | 2 |
MARK1 | 37 | 6 |
MARK2 | 28 | 2 |
MARK3 | 26 | 3 |
MARK4 | 46 | 2 |
MEKK1 | 30 | 0 |
MELK | 15 | 1 |
MINK1 |
4
|
0 |
MKK1 | 17 | 2 |
MLK1 |
6
|
1 |
MLK3 |
4
|
0 |
MNK1 | 99 | 4 |
MNK2 | 66 | 6 |
MSK1 | 70 | 9 |
MST2 | 21 | 3 |
MST4 | 35 | 0 |
NEK2a | 44 | 3 |
NEK6 | 135 | 13 |
NUAK1 |
6
|
0 |
p38 alpha MAPK | 59 | 4 |
p38 beta MAPK | 80 | 5 |
p38 delta MAPK | 36 | 1 |
p38 gamma MAPK | 38 | 0 |
PAK2 | 84 | 3 |
PAK4 |
7
|
0 |
PAK5 | 16 | 0 |
PAK6 | 31 | 1 |
PDK1 | 100 | 12 |
PHK | 55 | 1 |
PIM1 | 41 | 4 |
PIM2 | 81 | 4 |
PIM3 | 42 | 4 |
PKA | 96 | 3 |
PKB alpha | 108 | 4 |
PKB beta | 98 | 4 |
PKC alpha | 18 | 2 |
PKC zeta | 82 | 3 |
PKD1 | 11 | 1 |
PLK1 | 97 | 5 |
PRAK | 15 | 6 |
PRK2 | 29 | 9 |
RIPK2 | 12 | 1 |
ROCK 2 |
7
|
0 |
RSK1 | 31 | 3 |
RSK2 | 53 | 0 |
S6K1 | 39 | 0 |
SGK1 | 46 | 2 |
SmMLCK | 17 | 1 |
Src | 108 | 7 |
SRPK1 | 17 | 1 |
SYK | 56 | 2 |
TAK1 |
2
|
0 |
TBK1 | 47 | 7 |
TrkA | 28 | 4 |
TTK | 24 | 1 |
VEGFR1 | 22 | 1 |
YES1 | 13 | 4 |