Inhibitor | IRAK 1-4 Inhibitor 1  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IRAK 1-4 Inhibitor 1   C20H21N5O4 395.41 509093-47-4 11983295 IRAK1, IRAK4 Powers J. P. (2006) Bioorg. Med. Chem. Lett. 16 2842-2845

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
CLK2
4
 1
IRAK1
6
 5
MINK1
10
 1
IRAK4 12 1
CDK9-Cyclin T1 14 3
MAP4K3 14 2
CK1 gamma 2 17 9
MLK1 20 3
TrkA 22 0
TAK1 23 8
GCK 29 2
MAP4K5 31 1
NUAK1 34 10
MLK3 39 1
MPSK1 41 1
JNK3 41 1
PAK5 45 2
MELK 45 6
CK1 delta 47 3
EPH-B2 47 24
STK33 48 1
PAK4 50 10
DYRK1A 51 14
BTK 52 3
IRR 56 15
YES1 59 1
IR 60 8
PHK 60 15
IGF-1R 61 0
CDK2-Cyclin A 62 11
JAK2 63 10
PAK6 63 13
ERK5 66 3
JNK1 66 3
GSK3 beta 67 2
HIPK3 67 12
CAMKK beta 68 8
RSK2 69 4
MARK4 70 1
EPH-A4 71 1
SIK3 72 3
ERK8 72 1
TTK 72 2
HIPK2 72 6
p38 gamma MAPK 73 5
RSK1 73 13
MKK2 73 4
IKK beta 74 4
SIK2 74 3
PLK1 75 2
LKB1 75 1
MAPKAP-K2 76 14
PKC zeta 76 18
CSK 76 2
TLK1 77 9
MKK1 77 11
HIPK1 77 14
SGK1 79 6
MNK2 79 2
DYRK3 79 6
EPH-B3 80 12
S6K1 81 1
PIM3 81 10
JNK2 81 6
BRK 82 4
ROCK 2 82 8
MARK2 82 15
MARK3 82 8
ULK1 82 5
VEGFR1 83 9
MST3 83 3
TIE2 83 13
IKK epsilon 83 5
ASK1 84 24
DYRK2 84 4
PKD1 84 13
PKB beta 85 3
PDGFRA 85 20
PKC gamma 86 1
MAPKAP-K3 87 7
MARK1 87 17
PRK2 88 0
MEKK1 88 9
NEK2a 89 22
Lck 89 11
TAO1 90 8
PAK2 90 3
ABL 90 5
TSSK1 90 3
ERK2 90 8
ULK2 90 3
CHK2 90 7
TTBK1 91 4
SRPK1 91 5
MSK1 92 7
RIPK2 93 13
CAMK1 93 14
EPH-B1 93 4
PRAK 94 7
EPH-B4 94 9
PKA 95 2
TESK1 95 1
p38 alpha MAPK 96 7
SYK 97 2
OSR1 97 5
PKB alpha 97 7
HER4 97 6
MNK1 98 7
Aurora A 98 3
DDR2 98 0
WNK1 98 4
PINK 99 8
TGFBR1 99 8
TBK1 99 12
MST2 100 17
EIF2AK3 100 4
PIM1 100 5
PIM2 102 19
Aurora B 102 4
EF2K 102 5
CHK1 102 8
PKC alpha 103 6
MKK6 104 10
CK2 104 4
BRSK1 104 17
PDK1 104 9
MST4 105 16
ZAP70 106 1
AMPK (hum) 107 6
EPH-A2 107 4
BRSK2 107 38
p38 beta MAPK 110 42
p38 delta MAPK 112 9
SmMLCK 114 3
NEK6 115 5
DAPK1 116 13
Src 116 1
TTBK2 117 5
FGF-R1 117 16
ERK1 125 8
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
CLK2
6
 2
IRAK1
6
 2
IRAK4
9
 3
TrkA 20 3
TAK1 28 2
CDK9-Cyclin T1 42 1
CK1 gamma 2 48 5
CK1 delta 48 1
DYRK1A 48 12
MINK1 51 2
MLK3 54 4
CAMKK beta 55 3
PAK4 61 2
NUAK1 63 3
MNK2 64 15
MLK1 65 1
TBK1 67 8
EPH-B2 69 1
MAP4K3 69 5
JAK2 70 7
PLK1 70 1
IRR 71 1
GSK3 beta 71 1
MKK1 71 7
PHK 71 8
TTK 73 2
SGK1 73 11
BTK 74 27
RSK2 74 3
LKB1 74 4
MAP4K5 75 0
PAK5 76 8
HIPK2 78 3
TIE2 80 16
NEK2a 80 31
CHK1 81 29
RSK1 81 12
ERK5 81 2
IR 81 9
IKK beta 82 5
PKD1 82 5
GCK 82 1
MPSK1 82 4
ASK1 82 18
IGF-1R 82 10
ROCK 2 82 6
p38 gamma MAPK 83 18
CDK2-Cyclin A 84 4
SIK2 84 5
VEGFR1 84 7
PIM3 85 5
BRSK2 86 29
MELK 86 0
PKB beta 86 2
JNK3 87 5
PAK6 87 4
HIPK1 87 2
HIPK3 87 11
PKC gamma 88 1
MNK1 88 1
S6K1 88 6
TAO1 88 3
CSK 89 4
BRK 89 1
DYRK3 89 4
ABL 89 15
IKK epsilon 90 3
EPH-A4 90 2
SRPK1 91 7
MAPKAP-K2 91 0
MARK1 91 5
PKA 91 2
PKC zeta 92 16
TLK1 92 1
MEKK1 92 4
MKK2 92 16
MARK3 92 1
MARK2 93 4
DYRK2 93 6
STK33 94 1
WNK1 94 5
Lck 94 8
PAK2 94 8
PRK2 94 3
TTBK1 95 1
MARK4 95 6
MST4 96 8
MSK1 96 4
ULK2 96 4
PRAK 96 1
JNK2 96 1
CHK2 97 11
PIM1 97 0
TSSK1 97 15
PDK1 97 14
EIF2AK3 98 3
PDGFRA 98 6
CAMK1 98 12
p38 alpha MAPK 99 5
MST2 99 5
EPH-B1 99 10
MST3 99 11
SIK3 99 25
MAPKAP-K3 99 5
TESK1 99 2
PKC alpha 100 4
PIM2 100 13
SYK 100 10
EPH-B4 100 6
EPH-A2 100 12
ULK1 101 10
ERK2 101 13
YES1 102 5
HER4 103 10
JNK1 103 8
PKB alpha 104 1
MKK6 104 13
ERK8 105 9
OSR1 106 4
PINK 106 5
DDR2 107 18
BRSK1 107 7
RIPK2 109 19
Src 109 9
Aurora A 110 3
Aurora B 112 3
CK2 112 9
TGFBR1 112 1
EF2K 114 1
AMPK (hum) 115 1
SmMLCK 115 14
p38 beta MAPK 117 3
ZAP70 117 5
NEK6 117 2
p38 delta MAPK 118 26
TTBK2 118 7
FGF-R1 120 12
DAPK1 127 2
ERK1 130 1
EPH-B3 133 25