Inhibitor | IPA-3  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IPA-3   C20H14O2S2 350.45 42521-82-4 521106 PAK1 Deacon S.W. (2008) Chemistry and Biology 15 322

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 55 1
ASK1 129 8
Aurora A
2
 0
Aurora B
2
 0
BRSK1 29 2
BRSK2 39 0
BTK 28 5
CAMK1
6
 0
CAMKK beta 98 13
CDK2-Cyclin A 101 4
CHK1 89 6
CHK2 58 2
CK1 delta 96 4
CK2 104 6
CLK2 77 0
CSK 102 1
DAPK1 101 9
DYRK1A 47 1
DYRK2 68 6
DYRK3 54 9
EF2K 83 3
EPH-A2 91 11
EPH-A4 98 4
EPH-B1 118 13
EPH-B2 137 5
EPH-B3 86 12
EPH-B4 109 7
ERK1
9
 0
ERK2 56 4
ERK8
2
 1
FGF-R1 24 0
GCK 30 6
GSK3 beta 68 0
HER4 62 7
HIPK1 52 3
HIPK2 24 1
HIPK3 37 2
IGF-1R 87 1
IKK beta 33 3
IKK epsilon
7
 3
IR 110 6
IRAK4 47 1
IRR 84 2
JAK2 72 12
JNK1 99 8
JNK2 94 8
JNK3 106 4
Lck 99 2
LKB1 60 8
MAPKAP-K2 90 7
MAPKAP-K3 26 4
MARK1 65 5
MARK2 85 5
MARK3 81 4
MARK4 47 7
MEKK1 64 5
MELK 13 7
MINK1
3
 1
MKK1 85 1
MKK2 90 9
MKK6 93 3
MLK1 16 2
MLK3
9
 1
MNK1 88 2
MNK2 97 3
MSK1 79 5
MST2
5
 0
MST4
6
 1
NEK2a
10
 3
NEK6 34 6
NUAK1 11 1
p38 alpha MAPK 80 5
p38 beta MAPK 114 13
p38 delta MAPK 102 4
p38 gamma MAPK 97 3
PAK2
5
 1
PAK4 119 2
PAK5 99 6
PAK6 86 4
PDK1 106 6
PHK 100 0
PIM1 37 1
PIM2 65 2
PIM3 76 0
PKA 101 1
PKB alpha 87 7
PKB beta
1
 0
PKC alpha 91 5
PKC zeta 44 6
PKD1 24 1
PLK1 90 14
PRAK 86 1
PRK2 72 7
RIPK2 117 10
ROCK 2 95 0
RSK1 78 11
RSK2 12 1
S6K1 56 0
SGK1 89 7
SmMLCK 74 10
Src 42 7
SRPK1 62 2
SYK 77 4
TAK1 47 9
TAO1 103 1
TBK1 59 5
TrkA 63 5
TTK 68 2
VEGFR1
6
 1
YES1 59 2
Screen Conc: 5.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 27 4
ASK1 154 10
Aurora A
2
 0
Aurora B
2
 1
BRSK1 24 5
BRSK2 14 6
BTK 19 2
CAMK1
3
 0
CAMKK beta 49 7
CDK2-Cyclin A 106 1
CHK1 88 8
CHK2 34 6
CK1 delta 94 5
CK2 97 4
CLK2 48 4
CSK 109 2
DAPK1 83 8
DYRK1A 19 4
DYRK2 45 1
DYRK3 33 4
EF2K 60 8
EPH-A2 75 7
EPH-A4 89 5
EPH-B1 102 10
EPH-B2 169 8
EPH-B3 69 6
EPH-B4 119 8
ERK1
6
 2
ERK2 39 5
ERK8
1
 0
FGF-R1
4
 1
GCK
2
 0
GSK3 beta 30 3
HER4 49 6
HIPK1 48 1
HIPK2 15 1
HIPK3 33 10
IGF-1R 94 10
IKK beta
6
 2
IKK epsilon
4
 1
IR 93 7
IRAK4
9
 1
IRR 47 1
JAK2 34 1
JNK1 76 1
JNK2 80 7
JNK3 77 8
Lck 99 1
LKB1 17 1
MAPKAP-K2 69 1
MAPKAP-K3
10
 1
MARK1 38 5
MARK2 66 10
MARK3 63 1
MARK4 41 3
MEKK1 38 3
MELK 14 5
MINK1
1
 1
MKK1 18 1
MKK2 48 6
MKK6 70 3
MLK1
4
 1
MLK3
2
 0
MNK1 76 12
MNK2 78 10
MSK1 65 0
MST2
6
 0
MST4
8
 8
NEK2a
8
 1
NEK6 11 0
NUAK1
6
 2
p38 alpha MAPK 68 13
p38 beta MAPK 112 13
p38 delta MAPK 102 15
p38 gamma MAPK 99 4
PAK2
2
 0
PAK4 45 6
PAK5 49 14
PAK6 45 6
PDK1 75 13
PHK 103 6
PIM1 15 3
PIM2 21 5
PIM3 17 1
PKA 92 2
PKB alpha 62 7
PKB beta
0
 0
PKC alpha 48 12
PKC zeta 11 6
PKD1
10
 1
PLK1 12 2
PRAK 46 12
PRK2 30 2
RIPK2 114 10
ROCK 2 87 3
RSK1 62 6
RSK2
6
 1
S6K1 14 3
SGK1 48 0
SmMLCK 51 5
Src 17 1
SRPK1 47 4
SYK 12 1
TAK1 15 7
TAO1 102 3
TBK1 22 5
TrkA 19 2
TTK 40 5
VEGFR1
4
 1
YES1 34 2
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 90 7
Aurora B
5
 0
BRSK2 48 4
BTK 27 2
CAMK1
7
 2
CAMKK beta 90 0
CDK2-Cyclin A 88 0
CHK1 88 0
CHK2 94 8
CK1 delta 130 25
CK2 127 3
CSK 99 7
DYRK1A 83 3
DYRK2 64 9
DYRK3 74 1
EF2K 89 8
EPH-A2 97 4
EPH-B3 26 1
ERK1
8
 5
ERK2 101 5
ERK8 49 3
FGF-R1 29 1
GSK3 beta 106 8
HIPK2 73 4
IGF-1R 84 1
IKK beta 68 3
IKK epsilon 70 1
IR 113 6
IRR 83 0
JNK1 89 5
JNK2 94 17
Lck 90 5
MAPKAP-K2 76 0
MARK3 69 2
MELK 97 2
MKK1 96 0
MNK1 100 5
MNK2 87 11
MSK1 101 5
MST2 51 0
MST4 53 3
NEK2a 54 12
NEK6 65 18
p38 alpha MAPK 83 8
p38 beta MAPK 117 12
p38 delta MAPK 104 5
p38 gamma MAPK 103 12
PAK4 98 9
PAK5 121 2
PAK6 101 4
PDK1 86 14
PHK 108 2
PIM1 46 0
PIM2 81 7
PIM3 58 3
PKA 100 0
PKB alpha 85 0
PKB beta
0
 0
PKC alpha 65 2
PKC zeta 39 5
PKD1 28 4
PLK1
9
 3
PRAK 102 6
PRK2 87 6
ROCK 2 78 5
RSK1 184 133
RSK2
6
 2
S6K1
3
 0
SGK1 107 5
SmMLCK 87 1
Src 89 0
SRPK1 84 12
SYK 92 0
TBK1 77 2
VEGFR1 47 0
YES1 60 3