Inhibitor | BI-78D3  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
PKB beta	1	0
NEK2a	1	0
BTK	2	0
Aurora B	2	0
PLK1	3	0
CAMK1	12	3
S6K1	18	0
NEK6	24	2
RSK2	24	2
IKK beta	27	2
MST4	34	4
VEGFR1	38	1
PKC alpha	49	2
EPH-B3	62	4
PKD1	63	2
PIM1	63	0
YES1	63	4
DYRK3	64	3
PKC zeta	65	2
RSK1	69	12
BRSK2	70	8
TBK1	73	9
DYRK2	76	3
MELK	78	14
PIM3	78	1
IKK epsilon	79	0
MST2	80	3
PRAK	80	4
CAMKK beta	80	1
IRR	82	5
MAPKAP-K2	82	9
Src	82	7
ERK1	83	5
MARK3	83	5
EF2K	83	6
GSK3 beta	84	4
CDK2-Cyclin A	84	8
MSK1	85	0
CHK2	87	0
JNK2	87	0
MKK1	90	8
MNK2	90	0
SmMLCK	91	11
AMPK	91	11
CSK	91	7
ROCK 2	91	2
PAK6	91	0
IGF-1R	91	1
Lck	93	2
p38 alpha MAPK	94	4
JNK1	95	1
SYK	95	3
PRK2	95	3
MNK1	96	0
ERK2	98	0
PKA	98	4
DYRK1A	98	5
PKB alpha	98	10
CHK1	100	3
PAK5	101	5
p38 delta MAPK	104	3
PHK	105	2
SRPK1	105	8
CK2	106	4
EPH-A2	110	16
p38 beta MAPK	110	2
p38 gamma MAPK	110	2
SGK1	116	17
FGF-R1	116	13
HIPK2	118	1
IR	119	9
CK1 delta	119	5
PAK4	120	1
PIM2	123	11
PDK1	125	7
ERK8	148	26

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
BTK	23	4
NEK2a	25	6
Aurora B	38	4
VEGFR1	38	1
HER4	46	13
PKB beta	46	5
CAMK1	50	2
MLK1	51	0
RSK2	53	5
Src	55	8
PIM1	68	2
MINK1	68	6
AMPK	71	3
BRSK2	71	2
Aurora A	71	3
MARK2	72	8
MARK4	72	1
MAPKAP-K3	73	5
IKK epsilon	73	1
PLK1	73	1
EPH-A2	74	9
LKB1	74	7
PAK6	74	4
TBK1	75	1
DAPK1	75	5
p38 delta MAPK	75	0
DYRK2	75	3
RSK1	76	11
PKD1	77	5
TrkA	77	8
YES1	78	8
PAK5	79	7
MST2	80	3
MKK2	80	11
p38 alpha MAPK	81	7
IRAK4	81	9
IKK beta	82	0
MST4	82	5
IRR	82	5
MSK1	82	2
CAMKK beta	83	11
MARK3	84	2
GCK	84	3
CDK2-Cyclin A	84	7
MKK1	84	15
TTK	84	6
CSK	85	2
SRPK1	85	5
NUAK1	85	14
TAO1	85	2
PRK2	86	6
BRSK1	86	11
MELK	86	5
HIPK1	86	10
PRAK	87	1
p38 gamma MAPK	87	5
GSK3 beta	87	4
ROCK 2	88	1
FGF-R1	88	4
p38 beta MAPK	89	2
EF2K	89	6
MLK3	89	6
DYRK3	89	10
TAK1	90	2
PDK1	90	4
PAK2	90	8
PAK4	90	10
MKK6	90	1
EPH-B3	91	8
EPH-B4	91	2
S6K1	92	4
SmMLCK	92	9
CHK1	92	10
CLK2	92	2
PKB alpha	92	1
RIPK2	92	12
Lck	93	2
JNK1	93	2
PIM3	93	8
HIPK3	93	4
SGK1	93	2
NEK6	93	2
MAPKAP-K2	94	9
ERK2	94	14
MARK1	94	0
JAK2	94	4
PKA	95	3
JNK3	95	3
ASK1	95	3
MNK2	95	3
MEKK1	96	3
JNK2	97	3
CHK2	97	8
DYRK1A	97	1
PKC alpha	98	5
MNK1	98	10
EPH-B1	99	5
PIM2	100	14
HIPK2	100	4
CK1 delta	101	4
IR	102	1
EPH-A4	102	4
SYK	103	13
PKC zeta	103	3
PHK	107	1
IGF-1R	107	7
CK2	108	2
ERK8	113	3
EPH-B2	119	2
ERK1	123	8

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
MLK1	59	1
BTK	71	4
NEK2a	74	5
VEGFR1	77	9
HER4	78	4
PAK6	79	5
NUAK1	80	4
CAMK1	80	4
PAK5	81	5
Aurora B	82	1
TBK1	82	2
CDK2-Cyclin A	82	5
AMPK	83	8
IR	83	12
CAMKK beta	84	7
p38 gamma MAPK	85	9
LKB1	85	3
MARK4	86	1
HIPK1	86	10
DYRK2	86	1
MARK2	87	4
Aurora A	88	0
IGF-1R	88	13
SmMLCK	88	8
MARK1	88	8
EPH-A2	88	15
PKD1	89	3
RSK2	89	2
MAPKAP-K3	89	2
JAK2	89	14
PIM1	89	5
MSK1	90	1
MLK3	90	2
BRSK2	90	5
PKB beta	90	8
PLK1	91	1
RSK1	91	2
EPH-B3	91	12
FGF-R1	91	3
HIPK3	91	4
YES1	92	1
IRAK4	92	1
SYK	92	7
JNK1	92	6
PRK2	92	9
TTK	92	10
p38 delta MAPK	93	1
MAPKAP-K2	93	4
IKK epsilon	93	4
TAK1	93	6
RIPK2	93	0
GSK3 beta	93	1
PRAK	94	0
MINK1	94	10
MKK2	95	1
ROCK 2	95	6
ERK2	96	7
CLK2	96	6
SRPK1	97	0
EPH-B1	97	6
IKK beta	97	5
MST2	97	7
EPH-B4	97	2
PDK1	97	4
HIPK2	97	8
GCK	97	9
p38 alpha MAPK	97	8
IRR	98	12
PKA	98	3
PKC alpha	98	0
MARK3	98	6
p38 beta MAPK	99	0
BRSK1	99	11
PKB alpha	99	1
CK1 delta	99	2
PIM2	99	6
EPH-A4	99	9
MNK2	100	2
TAO1	100	9
ASK1	100	4
CSK	101	11
MKK1	101	12
S6K1	101	7
DAPK1	101	1
SGK1	102	0
CHK1	102	14
PAK4	102	10
EPH-B2	103	6
MKK6	103	6
TrkA	103	7
ERK8	105	2
MST4	105	8
DYRK1A	105	5
JNK2	105	3
DYRK3	105	1
MNK1	106	15
ERK1	106	4
PAK2	106	6
Lck	107	4
PKC zeta	107	8
JNK3	108	13
EF2K	109	12
CHK2	109	3
NEK6	111	14
PIM3	115	5
PHK	117	4
CK2	118	4
MEKK1	120	0
MELK	121	7
Src	122	4