Inhibitor | Crenolanib  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Crenolanib   C26H29N5O2 443.50 670220-88-9 10366136 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
MAP4K3
0
 0
PHK
1
 0
MLK1
2
 1
TrkA
2
 0
AMPK (hum)
2
 1
CAMKK beta
3
 0
MLK3
4
 1
NUAK1
4
 0
ULK2
4
 1
VEGFR1
5
 1
MST2
5
 1
PRK2
5
 1
SIK2
6
 3
MAP4K5
6
 1
CDK2-Cyclin A
6
 1
MARK3
8
 2
RIPK2
10
 0
ERK8
10
 1
DDR2
10
 3
PDGFRA
10
 1
SIK3 11 11
CDK9-Cyclin T1 12 2
GCK 13 4
RSK1 14 1
MARK1 14 1
MNK2 16 1
MINK1 17 1
Lck 21 4
Aurora B 23 6
MARK4 24 3
YES1 26 3
IRAK4 28 5
BRSK1 30 0
DYRK1A 31 1
MARK2 31 0
MKK2 32 2
MELK 34 6
MNK1 35 4
ROCK 2 36 3
ULK1 36 8
MKK1 39 0
TAK1 41 9
MST3 41 2
BRSK2 41 4
ABL 45 1
TSSK1 46 3
RSK2 46 4
DYRK3 47 2
IRAK1 48 3
CLK2 49 8
TAO1 52 2
TBK1 55 7
ERK5 57 1
CAMK1 58 0
MSK1 60 1
PAK4 61 12
PIM1 61 7
PKD1 66 2
JAK2 66 4
EPH-A4 69 10
Src 72 7
LKB1 72 5
TTK 75 18
FGF-R1 77 3
CHK1 77 4
PKC alpha 78 8
IRR 80 6
S6K1 80 4
SGK1 80 4
CSK 81 7
PAK5 81 1
CK1 gamma 2 85 14
EPH-A2 86 7
SYK 87 13
IKK epsilon 87 6
PIM3 87 1
PKC gamma 89 5
MEKK1 89 2
JNK3 90 14
HIPK2 90 10
MST4 91 0
PIM2 91 4
p38 alpha MAPK 92 6
TIE2 92 0
STK33 93 18
NEK6 93 5
PDK1 94 2
MKK6 94 6
GSK3 beta 95 12
DAPK1 95 15
PAK2 96 2
EPH-B2 96 10
IR 97 17
PRAK 98 0
ERK2 98 7
EPH-B4 98 9
JNK2 99 4
EPH-B3 99 4
CK1 delta 100 10
CK2 100 2
IKK beta 100 7
JNK1 100 7
HIPK3 101 15
PAK6 101 11
SRPK1 102 3
SmMLCK 102 8
DYRK2 103 9
p38 gamma MAPK 104 1
PLK1 104 6
PKB alpha 104 12
ERK1 105 10
PKA 105 8
Aurora A 106 5
CHK2 107 4
p38 delta MAPK 107 5
TTBK1 107 4
TTBK2 107 0
ZAP70 107 5
HER4 108 11
TLK1 108 8
ASK1 108 3
MPSK1 108 22
EF2K 109 5
HIPK1 109 0
OSR1 109 11
WNK1 109 7
EPH-B1 110 5
IGF-1R 111 8
BRK 111 19
EIF2AK3 112 2
MAPKAP-K2 112 4
BTK 113 3
PKC zeta 115 12
NEK2a 117 4
p38 beta MAPK 118 1
MAPKAP-K3 120 14
PKB beta 120 30
PINK 122 8
TGFBR1 133 15
TESK1 146 16