Inhibitor | RO-3306  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
RO-3306   C₁₈H₁₃N₃OS₂ 351.50 872573-93-8 71433937 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 100 15
AMPK (hum) 40 1
ASK1 66 2
Aurora A 117 5
Aurora B 49 5
BRK 112 3
BRSK1 59 9
BRSK2 60 6
BTK 103 8
CAMK1 96 10
CAMKK beta 21 1
CDK2-Cyclin A 21 0
CDK9-Cyclin T1 82 5
CHK1 37 1
CHK2 36 2
CK1 delta 81 15
CK1 gamma 2 88 8
CK2 66 7
CLK2
6
 0
CSK 93 16
DAPK1 62 4
DDR2 92 27
DYRK1A
2
 0
DYRK2 20 3
DYRK3 14 1
EF2K 93 2
EIF2AK3 98 7
EPH-A2 105 5
EPH-A4 115 1
EPH-B1 81 21
EPH-B2 99 4
EPH-B3 101 2
EPH-B4 95 11
ERK1 68 1
ERK2 80 16
ERK5 40 1
ERK8
8
 0
FGF-R1 93 3
GCK
8
 1
GSK3 beta 64 6
HER4 81 17
HIPK1 62 9
HIPK2 43 2
HIPK3 52 5
IGF-1R 49 1
IKK beta 80 9
IKK epsilon 64 6
IR 97 7
IRAK1 25 2
IRAK4 83 8
IRR 86 9
JAK2 97 5
JNK1 89 8
JNK2 89 12
JNK3 95 13
Lck 93 3
LKB1 90 6
MAP4K3 53 3
MAP4K5 69 2
MAPKAP-K2 86 11
MAPKAP-K3 90 14
MARK1 81 3
MARK2 97 11
MARK3 75 2
MARK4 81 3
MEKK1 96 8
MELK 52 1
MINK1 12 1
MKK1 52 1
MKK2 78 20
MKK6 88 7
MLK1 88 4
MLK3 63 7
MNK1 63 0
MNK2 27 4
MPSK1 99 9
MSK1 65 6
MST2 85 6
MST3 80 2
MST4 54 8
NEK2a 49 2
NEK6 101 24
NUAK1 44 1
OSR1 103 1
p38 alpha MAPK 93 4
p38 beta MAPK 101 11
p38 delta MAPK 68 12
p38 gamma MAPK 26 2
PAK2 100 9
PAK4 79 5
PAK5 98 4
PAK6 102 9
PDGFRA 103 9
PDK1 102 34
PHK 50 2
PIM1 12 1
PIM2 92 1
PIM3 50 7
PINK 107 6
PKA 89 0
PKB alpha 86 5
PKB beta 78 6
PKC alpha 111 1
PKC gamma 69 1
PKC zeta 114 4
PKD1 38 4
PLK1 95 8
PRAK 110 24
PRK2
8
 0
RIPK2 12 1
ROCK 2 34 1
RSK1 49 1
RSK2 61 2
S6K1 43 11
SGK1 51 0
SIK2 92 4
SIK3 83 4
SmMLCK 43 8
Src 90 9
SRPK1 89 8
STK33 72 15
SYK 106 7
TAK1 83 2
TAO1 51 6
TBK1 60 8
TESK1 72 16
TGFBR1 96 9
TIE2 78 6
TLK1 113 8
TrkA 96 15
TSSK1 41 3
TTBK1 88 8
TTBK2 103 0
TTK 65 2
ULK1 89 5
ULK2 77 10
VEGFR1 59 1
WNK1 105 3
YES1 82 0
ZAP70 96 5
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 70 9
AMPK (hum)
10
 1
ASK1 26 0
Aurora A 127 20
Aurora B 13 4
BRK 115 6
BRSK1 23 1
BRSK2 21 2
BTK 78 6
CAMK1 73 5
CAMKK beta
7
 0
CDK2-Cyclin A
5
 0
CDK9-Cyclin T1 42 1
CHK1 13 1
CHK2
8
 0
CK1 delta 86 3
CK1 gamma 2 49 4
CK2 20 3
CLK2
1
 0
CSK 81 1
DAPK1 26 1
DDR2 100 3
DYRK1A
1
 0
DYRK2
4
 0
DYRK3
4
 0
EF2K 89 4
EIF2AK3 102 16
EPH-A2 98 6
EPH-A4 107 9
EPH-B1 75 8
EPH-B2 93 14
EPH-B3 99 6
EPH-B4 108 12
ERK1 27 0
ERK2 44 4
ERK5 24 1
ERK8
2
 1
FGF-R1 88 1
GCK
3
 1
GSK3 beta 27 4
HER4 81 13
HIPK1 18 3
HIPK2 13 0
HIPK3 18 2
IGF-1R 46 8
IKK beta 71 2
IKK epsilon 16 0
IR 90 4
IRAK1
5
 1
IRAK4 41 0
IRR 71 6
JAK2 41 2
JNK1 99 8
JNK2 78 8
JNK3 96 11
Lck 63 2
LKB1 58 4
MAP4K3 11 1
MAP4K5 35 5
MAPKAP-K2 40 5
MAPKAP-K3 77 2
MARK1 48 3
MARK2 83 6
MARK3 35 4
MARK4 73 4
MEKK1 103 2
MELK 12 2
MINK1
4
 0
MKK1 17 4
MKK2 37 4
MKK6 81 2
MLK1 55 2
MLK3 30 5
MNK1 43 18
MNK2 14 7
MPSK1 119 17
MSK1 24 2
MST2 48 13
MST3 67 4
MST4 22 2
NEK2a
10
 2
NEK6 108 11
NUAK1 12 0
OSR1 104 1
p38 alpha MAPK 95 11
p38 beta MAPK 96 9
p38 delta MAPK 25 1
p38 gamma MAPK 11 2
PAK2 82 7
PAK4 35 7
PAK5 62 0
PAK6 61 2
PDGFRA 96 10
PDK1 98 19
PHK 22 1
PIM1
2
 0
PIM2 45 3
PIM3 14 3
PINK 112 9
PKA 48 4
PKB alpha 71 1
PKB beta 57 4
PKC alpha 88 6
PKC gamma 22 1
PKC zeta 99 16
PKD1 15 0
PLK1 107 4
PRAK 76 22
PRK2
3
 1
RIPK2
5
 1
ROCK 2
10
 0
RSK1 15 1
RSK2 37 6
S6K1 16 0
SGK1 14 1
SIK2 54 4
SIK3 55 0
SmMLCK 14 0
Src 77 5
SRPK1 79 7
STK33 34 2
SYK 116 11
TAK1 53 1
TAO1 13 2
TBK1 20 2
TESK1 82 4
TGFBR1 115 3
TIE2 62 0
TLK1 120 14
TrkA 60 6
TSSK1
9
 0
TTBK1 92 2
TTBK2 102 12
TTK 51 11
ULK1 47 4
ULK2 38 0
VEGFR1 22 4
WNK1 109 15
YES1 46 2
ZAP70 104 1