Inhibitor | Dasatinib  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Dasatinib   C22H26ClN7O2S 487.00 302962-49-8 3062316 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
EPH-B1
-1
 2
ABL
0
 0
DDR2
0
 0
Lck
1
 0
YES1
1
 0
EPH-A2
1
 0
BTK
1
 0
EPH-B2
1
 0
EPH-B3
1
 0
Src
2
 0
BRK
2
 0
EPH-A4
2
 2
SIK2
2
 1
SIK3
2
 0
PDGFRA
3
 1
MAP4K5
3
 1
EPH-B4
3
 0
HER4
6
 0
TESK1
8
 0
CSK
8
 3
RIPK2
10
 12
p38 alpha MAPK 29 2
MLK3 39 6
MLK1 41 2
JAK2 42 1
p38 beta MAPK 44 4
MINK1 51 1
VEGFR1 53 4
MAP4K3 54 1
GCK 56 8
CAMK1 77 1
MST4 77 4
TIE2 78 5
CK2 80 28
MST2 81 6
TGFBR1 82 5
FGF-R1 84 6
TrkA 88 2
IRR 90 14
SYK 90 0
MKK2 91 0
ULK2 91 3
ERK5 91 4
PDK1 92 1
MST3 93 2
IR 94 7
PKB beta 94 2
TAO1 95 7
EF2K 95 5
ERK8 95 11
CHK1 96 6
SGK1 96 7
TBK1 97 10
HIPK2 97 5
NEK2a 98 4
IGF-1R 98 7
PIM1 98 1
IKK beta 99 9
PLK1 99 15
TAK1 99 7
CAMKK beta 99 19
LKB1 100 14
RSK2 101 3
PRK2 101 0
OSR1 101 0
ULK1 101 0
Aurora A 101 1
IRAK4 102 6
RSK1 102 5
DAPK1 102 7
MEKK1 102 1
CHK2 102 1
MNK1 102 9
ERK2 102 1
PHK 103 1
MSK1 103 1
DYRK3 104 9
MARK3 104 5
WNK1 104 12
PIM2 105 1
p38 gamma MAPK 105 7
PKC alpha 105 14
MNK2 106 2
PKD1 107 15
SRPK1 107 9
BRSK2 108 13
PIM3 108 5
Aurora B 108 10
IRAK1 108 3
TTK 109 9
PKC zeta 109 7
STK33 110 4
SmMLCK 111 7
MAPKAP-K2 111 7
MKK6 112 4
CDK2-Cyclin A 112 1
TTBK1 112 1
JNK3 113 15
TSSK1 113 3
S6K1 113 11
EIF2AK3 113 2
HIPK3 113 7
CK1 gamma 2 113 12
PKC gamma 114 22
ERK1 114 12
MARK4 115 24
DYRK2 117 9
TTBK2 117 7
NUAK1 118 8
ASK1 118 7
PAK2 119 12
PAK6 120 4
PKB alpha 120 13
AMPK (hum) 120 5
JNK1 121 9
CLK2 121 6
GSK3 beta 121 12
PKA 121 27
ZAP70 121 27
HIPK1 122 6
NEK6 123 6
BRSK1 123 1
IKK epsilon 123 13
MPSK1 123 1
CK1 delta 124 1
TLK1 124 0
JNK2 125 0
MARK2 126 2
DYRK1A 126 19
MARK1 127 3
PRAK 128 7
MELK 128 7
ROCK 2 132 7
PAK4 132 16
MAPKAP-K3 132 1
PINK 133 5
p38 delta MAPK 133 1
MKK1 134 16
PAK5 138 7
CDK9-Cyclin T1 138 12
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
EPH-B1
-1
 1
ABL
0
 0
Lck
1
 0
YES1
1
 0
EPH-A2
1
 0
BTK
1
 0
EPH-B2
1
 0
EPH-B3
1
 0
DDR2
1
 1
Src
1
 0
EPH-A4
2
 0
SIK2
4
 1
BRK
5
 0
RIPK2
5
 0
PDGFRA
6
 1
SIK3
9
 2
EPH-B4 20 0
MAP4K5 22 1
HER4 27 1
TESK1 50 3
MLK1 72 1
MST2 75 2
MLK3 76 10
VEGFR1 78 9
p38 alpha MAPK 79 15
RSK2 86 9
SGK1 87 11
ERK5 87 2
FGF-R1 88 7
TIE2 88 7
MAP4K3 88 15
IRR 89 4
CAMK1 89 16
PIM1 90 1
MINK1 90 4
ERK8 90 14
ERK1 91 6
PKD1 92 21
ERK2 93 9
PDK1 94 9
PKB beta 94 11
Aurora A 94 0
JAK2 94 2
MSK1 94 4
HIPK2 95 1
GCK 95 7
ULK1 95 9
CK2 95 3
LKB1 96 18
MARK3 96 16
PIM3 96 8
CAMKK beta 96 4
IRAK1 96 1
TLK1 96 4
MNK2 97 8
MST4 97 10
CSK 97 19
TAK1 97 23
SYK 97 1
IKK beta 97 21
CHK2 98 8
PKC alpha 98 3
DYRK3 98 7
MEKK1 98 4
IR 99 2
CHK1 100 6
OSR1 100 1
PRK2 100 2
TBK1 100 1
p38 gamma MAPK 100 4
MPSK1 101 5
DYRK2 101 5
PKC zeta 101 3
ULK2 101 3
PHK 101 10
IKK epsilon 102 5
HIPK3 102 3
BRSK2 102 14
GSK3 beta 103 2
PKB alpha 103 15
TGFBR1 103 1
TTK 104 6
WNK1 104 4
PIM2 104 3
MKK6 104 11
SRPK1 104 9
EF2K 104 4
p38 beta MAPK 105 11
MARK4 105 12
STK33 105 6
RSK1 105 2
HIPK1 105 4
TSSK1 106 11
EIF2AK3 106 6
AMPK (hum) 107 13
IGF-1R 107 6
PKC gamma 107 22
TrkA 107 11
JNK1 108 4
JNK3 108 0
ASK1 108 7
S6K1 108 3
MNK1 108 0
ZAP70 109 1
TTBK2 110 5
JNK2 110 10
PKA 110 12
DYRK1A 111 4
SmMLCK 111 4
TTBK1 112 8
MELK 112 7
IRAK4 112 24
MKK2 113 11
CK1 delta 113 4
NEK6 113 4
MST3 114 20
MAPKAP-K2 114 4
MARK1 115 3
CK1 gamma 2 115 0
CDK2-Cyclin A 116 1
PINK 117 1
MAPKAP-K3 117 3
MKK1 118 10
MARK2 118 4
PAK2 118 2
p38 delta MAPK 118 17
NUAK1 119 10
TAO1 120 9
CLK2 120 6
Aurora B 120 10
CDK9-Cyclin T1 122 8
NEK2a 122 11
PAK6 126 9
BRSK1 126 0
DAPK1 126 10
PRAK 129 14
ROCK 2 130 10
PAK5 131 12
PLK1 133 18
PAK4 137 21