Inhibitor | Metformin  

Screen Conc: 100.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	96	2
AMPK (hum)	92	5
ASK1	98	0
Aurora A	102	7
Aurora B	76	4
BRK	81	1
BRSK1	88	1
BRSK2	81	0
BTK	78	32
CAMK1	86	10
CAMKK beta	92	7
CDK2-Cyclin A	96	2
CDK9-Cyclin T1	78	7
CHK1	93	1
CHK2	97	4
CK1 delta	89	2
CK1 gamma 2	91	9
CK2	88	1
CLK2	94	12
CSK	88	1
DAPK1	91	1
DDR2	109	10
DYRK1A	89	18
DYRK2	91	9
DYRK3	97	4
EF2K	86	0
EIF2AK3	82	1
EPH-A2	81	4
EPH-A4	89	10
EPH-B1	82	5
EPH-B2	99	1
EPH-B3	93	2
EPH-B4	63	5
ERK1	95	2
ERK2	96	1
ERK5	87	1
ERK8	85	8
FGF-R1	79	2
GCK	87	4
GSK3 beta	88	7
HER4	77	17
HIPK1	90	1
HIPK2	94	1
HIPK3	96	8
IGF-1R	129	7
IKK beta	97	0
IKK epsilon	86	6
IR	95	4
IRAK1	111	3
IRAK4	134	59
IRR	97	2
JAK2	85	3
JNK1	90	8
JNK2	75	1
JNK3	92	14
Lck	97	10
LKB1	95	26
MAP4K3	94	17
MAP4K5	91	15
MAPKAP-K2	93	1
MAPKAP-K3	91	7
MARK1	93	12
MARK2	98	4
MARK3	95	8
MARK4	94	9
MEKK1	92	6
MELK	100	14
MINK1	74	9
MKK1	90	6
MKK2	98	9
MKK6	79	3
MLK1	92	3
MLK3	83	1
MNK1	92	3
MNK2	98	11
MPSK1	87	3
MSK1	92	11
MST2	107	13
MST3	88	2
MST4	97	7
NEK2a	106	9
NEK6	88	34
NUAK1	81	16
OSR1	97	16
p38 alpha MAPK	80	1
p38 beta MAPK	101	6
p38 delta MAPK	89	4
p38 gamma MAPK	85	3
PAK2	98	1
PAK4	91	19
PAK5	102	6
PAK6	107	9
PDGFRA	97	3
PDK1	90	6
PHK	103	6
PIM1	103	1
PIM2	103	15
PIM3	89	1
PINK	96	6
PKA	94	9
PKB alpha	101	2
PKB beta	96	4
PKC alpha	118	24
PKC gamma	88	9
PKC zeta	104	7
PKD1	89	0
PLK1	95	8
PRAK	104	7
PRK2	96	3
RIPK2	95	4
ROCK 2	89	4
RSK1	88	11
RSK2	84	3
S6K1	97	6
SGK1	88	1
SIK2	90	1
SIK3	94	10
SmMLCK	93	1
Src	87	8
SRPK1	82	3
STK33	94	9
SYK	74	10
TAK1	96	1
TAO1	87	14
TBK1	81	4
TESK1	96	1
TGFBR1	93	2
TIE2	90	7
TLK1	90	5
TrkA	80	11
TSSK1	81	4
TTBK1	93	5
TTBK2	91	4
TTK	108	6
ULK1	93	3
ULK2	106	6
VEGFR1	89	6
WNK1	92	20
YES1	96	14
ZAP70	89	1

Screen Conc: 250.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	94	11
AMPK (hum)	97	9
ASK1	97	1
Aurora A	100	5
Aurora B	83	5
BRK	90	2
BRSK1	95	4
BRSK2	93	1
BTK	74	27
CAMK1	86	5
CAMKK beta	88	4
CDK2-Cyclin A	113	0
CDK9-Cyclin T1	92	0
CHK1	93	2
CHK2	93	2
CK1 delta	87	3
CK1 gamma 2	104	10
CK2	100	4
CLK2	89	3
CSK	92	3
DAPK1	93	1
DDR2	99	6
DYRK1A	93	2
DYRK2	84	3
DYRK3	109	5
EF2K	101	5
EIF2AK3	87	5
EPH-A2	104	24
EPH-A4	95	10
EPH-B1	98	5
EPH-B2	112	8
EPH-B3	103	4
EPH-B4	77	3
ERK1	102	10
ERK2	100	11
ERK5	94	2
ERK8	101	2
FGF-R1	82	4
GCK	95	1
GSK3 beta	93	14
HER4	81	0
HIPK1	93	8
HIPK2	112	18
HIPK3	107	12
IGF-1R	122	5
IKK beta	96	6
IKK epsilon	82	3
IR	94	4
IRAK1	111	3
IRAK4	98	3
IRR	97	7
JAK2	73	5
JNK1	99	2
JNK2	92	7
JNK3	100	8
Lck	89	1
LKB1	113	7
MAP4K3	87	1
MAP4K5	95	10
MAPKAP-K2	107	17
MAPKAP-K3	95	12
MARK1	94	3
MARK2	101	3
MARK3	95	17
MARK4	93	2
MEKK1	89	11
MELK	95	1
MINK1	75	4
MKK1	78	10
MKK2	101	13
MKK6	78	1
MLK1	106	17
MLK3	83	2
MNK1	95	3
MNK2	93	3
MPSK1	95	4
MSK1	104	7
MST2	112	5
MST3	98	1
MST4	107	11
NEK2a	101	5
NEK6	84	7
NUAK1	93	18
OSR1	99	6
p38 alpha MAPK	93	8
p38 beta MAPK	100	4
p38 delta MAPK	101	5
p38 gamma MAPK	87	11
PAK2	103	9
PAK4	88	1
PAK5	91	8
PAK6	95	10
PDGFRA	92	1
PDK1	100	6
PHK	100	3
PIM1	94	1
PIM2	99	13
PIM3	90	4
PINK	108	3
PKA	97	4
PKB alpha	98	1
PKB beta	108	4
PKC alpha	91	5
PKC gamma	103	9
PKC zeta	99	6
PKD1	94	6
PLK1	128	11
PRAK	100	5
PRK2	95	6
RIPK2	107	4
ROCK 2	94	2
RSK1	94	13
RSK2	83	1
S6K1	102	2
SGK1	102	1
SIK2	96	3
SIK3	87	5
SmMLCK	91	3
Src	86	3
SRPK1	95	1
STK33	100	11
SYK	80	5
TAK1	101	10
TAO1	104	7
TBK1	86	4
TESK1	86	7
TGFBR1	100	11
TIE2	82	10
TLK1	96	4
TrkA	78	11
TSSK1	90	0
TTBK1	92	3
TTBK2	90	10
TTK	108	14
ULK1	97	10
ULK2	110	2
VEGFR1	89	4
WNK1	97	14
YES1	96	17
ZAP70	93	0