Inhibitor | PRT062607  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PRT062607   C19H23N9O 393.45 1370261-96-3 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 107 5
AMPK (hum) 92 11
ASK1 106 18
Aurora A 98 6
Aurora B 71 16
BRK 82 5
BRSK1 109 23
BRSK2 107 5
BTK 57 1
CAMK1 77 2
CAMKK beta 101 3
CDK2-Cyclin A 53 4
CDK9-Cyclin T1 86 7
CHK1 92 22
CHK2 94 3
CK1 delta 54 2
CK1 gamma 2 99 20
CK2 96 0
CLK2 74 1
CSK 76 5
DAPK1 83 11
DDR2 102 7
DYRK1A 89 10
DYRK2 109 5
DYRK3 84 5
EF2K 101 23
EIF2AK3 91 4
EPH-A2 107 1
EPH-A4 83 9
EPH-B1 108 1
EPH-B2 98 15
EPH-B3 96 5
EPH-B4 107 6
ERK1 76 3
ERK2 96 3
ERK5 71 3
ERK8 84 4
FGF-R1 89 16
GCK 49 7
GSK3 beta 99 8
HER4 86 8
HIPK1 93 6
HIPK2 104 23
HIPK3 93 8
IGF-1R 47 8
IKK beta 84 4
IKK epsilon 88 10
IR 75 13
IRAK1 87 3
IRAK4 84 10
IRR 78 5
JAK2 75 4
JNK1 85 11
JNK2 86 4
JNK3 104 0
Lck 88 10
LKB1 64 8
MAP4K3 89 8
MAP4K5 94 14
MAPKAP-K2 105 1
MAPKAP-K3 107 1
MARK1 101 12
MARK2 99 4
MARK3 71 0
MARK4 97 16
MEKK1 98 2
MELK 84 3
MINK1 78 1
MKK1 80 5
MKK2 81 11
MKK6 85 3
MLK1 51 9
MLK3 29 4
MNK1 101 4
MNK2 102 3
MPSK1 110 1
MSK1 99 6
MST2 65 5
MST3 99 9
MST4 84 6
NEK2a 104 12
NEK6 96 4
NUAK1 100 5
OSR1 94 1
p38 alpha MAPK 98 8
p38 beta MAPK 98 16
p38 delta MAPK 103 6
p38 gamma MAPK 79 1
PAK2 100 12
PAK4 32 4
PAK5 33 4
PAK6 72 15
PDGFRA 95 13
PDK1 92 11
PHK 112 21
PIM1 66 5
PIM2 101 17
PIM3 84 2
PINK 85 2
PKA 82 14
PKB alpha 94 6
PKB beta 97 8
PKC alpha 79 10
PKC gamma 95 0
PKC zeta 114 7
PKD1 88 7
PLK1 88 9
PRAK 101 5
PRK2 78 3
RIPK2 93 5
ROCK 2 85 9
RSK1 91 3
RSK2 83 17
S6K1 87 14
SGK1 90 2
SIK2 66 2
SIK3 87 9
SmMLCK 79 8
Src 51 6
SRPK1 110 35
STK33 93 6
SYK
5
 2
TAK1 83 5
TAO1 98 13
TBK1 96 7
TESK1 101 2
TGFBR1 87 2
TIE2 99 8
TLK1 99 9
TrkA 38 4
TSSK1 84 4
TTBK1 101 0
TTBK2 90 11
TTK 92 4
ULK1 91 0
ULK2 109 12
VEGFR1 93 3
WNK1 106 7
YES1 41 12
ZAP70 89 8
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 90 11
AMPK (hum) 83 16
ASK1 95 8
Aurora A 105 15
Aurora B 71 6
BRK 25 3
BRSK1 96 8
BRSK2 97 10
BTK 17 4
CAMK1 21 0
CAMKK beta 67 4
CDK2-Cyclin A 28 0
CDK9-Cyclin T1 69 5
CHK1 40 12
CHK2 38 1
CK1 delta 13 2
CK1 gamma 2 74 4
CK2 78 1
CLK2 32 2
CSK 88 9
DAPK1 26 1
DDR2 73 0
DYRK1A 88 2
DYRK2 106 9
DYRK3 37 2
EF2K 84 7
EIF2AK3 86 2
EPH-A2 81 3
EPH-A4 27 0
EPH-B1 96 11
EPH-B2 54 1
EPH-B3 105 1
EPH-B4 94 13
ERK1 53 4
ERK2 48 10
ERK5 29 2
ERK8 42 4
FGF-R1 94 20
GCK 14 4
GSK3 beta 76 15
HER4 52 9
HIPK1 75 5
HIPK2 87 0
HIPK3 100 19
IGF-1R
4
 1
IKK beta 97 1
IKK epsilon 71 3
IR 27 7
IRAK1 52 2
IRAK4 24 2
IRR 40 4
JAK2 24 2
JNK1 88 20
JNK2 85 1
JNK3 80 1
Lck 36 1
LKB1 35 7
MAP4K3 39 12
MAP4K5 50 5
MAPKAP-K2 99 1
MAPKAP-K3 105 14
MARK1 66 2
MARK2 71 5
MARK3 31 2
MARK4 74 8
MEKK1 89 0
MELK 73 1
MINK1 53 8
MKK1 52 20
MKK2 48 16
MKK6 62 1
MLK1
6
 1
MLK3
9
 1
MNK1 72 7
MNK2 80 6
MPSK1 130 3
MSK1 75 5
MST2 21 5
MST3 68 6
MST4 65 3
NEK2a 101 22
NEK6 101 18
NUAK1 48 6
OSR1 79 1
p38 alpha MAPK 94 15
p38 beta MAPK 103 10
p38 delta MAPK 88 7
p38 gamma MAPK 69 1
PAK2 86 7
PAK4 12 2
PAK5
7
 0
PAK6 24 4
PDGFRA 72 3
PDK1 85 13
PHK 84 12
PIM1 13 0
PIM2 97 16
PIM3 27 1
PINK 44 2
PKA 82 3
PKB alpha 87 11
PKB beta 92 7
PKC alpha 45 7
PKC gamma 71 9
PKC zeta 110 4
PKD1 44 6
PLK1 81 12
PRAK 100 9
PRK2 38 5
RIPK2 57 4
ROCK 2 60 5
RSK1 73 7
RSK2 63 7
S6K1 77 3
SGK1 85 1
SIK2 19 3
SIK3 67 8
SmMLCK 35 1
Src 13 3
SRPK1 95 6
STK33 49 6
SYK
2
 1
TAK1 31 1
TAO1 64 16
TBK1 97 2
TESK1 55 5
TGFBR1 85 10
TIE2 94 17
TLK1 97 3
TrkA 16 3
TSSK1 34 2
TTBK1 92 4
TTBK2 98 5
TTK 81 3
ULK1 54 2
ULK2 66 3
VEGFR1 79 2
WNK1 98 2
YES1
10
 1
ZAP70 28 2
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 51 2
AMPK (hum) 22 2
ASK1 80 11
Aurora A 102 3
Aurora B 60 10
BRK
4
 0
BRSK1 66 2
BRSK2 73 8
BTK
9
 0
CAMK1
3
 0
CAMKK beta 21 1
CDK2-Cyclin A 20 1
CDK9-Cyclin T1 24 1
CHK1 11 2
CHK2
9
 0
CK1 delta
2
 0
CK1 gamma 2 30 5
CK2 32 4
CLK2
3
 0
CSK 48 1
DAPK1
5
 1
DDR2 27 6
DYRK1A 42 4
DYRK2 79 3
DYRK3
6
 0
EF2K 55 9
EIF2AK3 71 4
EPH-A2 25 3
EPH-A4
6
 0
EPH-B1 45 2
EPH-B2
4
 1
EPH-B3 58 1
EPH-B4 40 0
ERK1 15 0
ERK2 12 1
ERK5 13 1
ERK8
5
 2
FGF-R1 66 18
GCK
3
 1
GSK3 beta 41 11
HER4 12 2
HIPK1 52 6
HIPK2 54 5
HIPK3 78 8
IGF-1R
1
 1
IKK beta 85 7
IKK epsilon 30 1
IR
3
 1
IRAK1 15 2
IRAK4
7
 3
IRR 11 1
JAK2 12 1
JNK1 42 8
JNK2 47 7
JNK3 47 0
Lck
8
 1
LKB1 31 7
MAP4K3
4
 1
MAP4K5 15 2
MAPKAP-K2 91 8
MAPKAP-K3 88 6
MARK1 34 1
MARK2 26 5
MARK3
6
 1
MARK4 26 2
MEKK1 94 1
MELK 22 0
MINK1
8
 1
MKK1
5
 1
MKK2
4
 0
MKK6 31 0
MLK1
2
 2
MLK3
5
 1
MNK1 61 56
MNK2 31 5
MPSK1 108 1
MSK1 41 4
MST2
9
 2
MST3 14 4
MST4 26 2
NEK2a 45 5
NEK6 88 2
NUAK1
9
 2
OSR1 37 2
p38 alpha MAPK 83 7
p38 beta MAPK 77 13
p38 delta MAPK 47 0
p38 gamma MAPK 39 2
PAK2 47 8
PAK4 11 1
PAK5
2
 0
PAK6
4
 1
PDGFRA 36 1
PDK1 53 8
PHK 19 1
PIM1
2
 0
PIM2 55 8
PIM3
3
 0
PINK 11 1
PKA 57 6
PKB alpha 49 1
PKB beta 78 13
PKC alpha 14 5
PKC gamma 26 3
PKC zeta 86 4
PKD1 11 2
PLK1 69 11
PRAK 65 1
PRK2
10
 2
RIPK2 21 0
ROCK 2 22 1
RSK1 28 0
RSK2 30 6
S6K1 40 4
SGK1 82 0
SIK2
4
 1
SIK3 19 3
SmMLCK
7
 1
Src
3
 1
SRPK1 73 6
STK33 17 0
SYK
1
 0
TAK1
8
 1
TAO1 13 1
TBK1 75 5
TESK1 14 0
TGFBR1 88 9
TIE2 72 13
TLK1 67 4
TrkA
6
 3
TSSK1 14 1
TTBK1 62 3
TTBK2 49 15
TTK 47 1
ULK1 17 0
ULK2 23 3
VEGFR1 51 4
WNK1 61 2
YES1
3
 0
ZAP70
10
 0