Inhibitor | Fostamatinib  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
JAK2	-5	12
EPH-B1	3	0
MLK1	4	0
MLK3	4	0
PAK4	6	0
EPH-B2	6	1
ZAP70	7	1
IGF-1R	7	1
Lck	8	2
EPH-A2	9	2
IR	11	0
DDR2	14	5
BTK	15	0
CSK	16	2
ULK1	16	0
YES1	17	0
IRR	18	0
IKK epsilon	19	2
NUAK1	19	0
FGF-R1	22	1
IRAK1	24	3
JNK3	24	2
HER4	25	3
JNK2	26	1
S6K1	27	1
PAK5	27	8
AMPK (hum)	28	0
SGK1	30	3
ULK2	30	2
EPH-B3	31	6
ERK8	36	0
LKB1	37	2
SIK2	37	7
CLK2	39	0
TSSK1	43	0
Aurora A	45	62
TESK1	46	6
Aurora B	46	55
EPH-B4	48	58
SYK	54	49
PLK1	55	4
EIF2AK3	55	4
NEK2a	58	1
PAK2	59	6
MAP4K3	60	0
PKA	61	0
RSK1	62	17
CK2	62	5
IRAK4	62	4
TAK1	63	13
MST2	64	15
PAK6	64	6
CAMKK beta	66	20
MPSK1	66	8
TIE2	68	4
PRK2	69	8
JNK1	70	44
p38 delta MAPK	71	6
MSK1	71	7
MNK2	71	4
SIK3	72	9
PDGFRA	73	66
STK33	73	55
CHK2	74	33
TTK	74	4
DYRK2	74	7
TAO1	74	8
PDK1	74	55
MAP4K5	75	4
GSK3 beta	76	0
MARK4	76	9
IKK beta	77	10
RSK2	78	35
PKC alpha	78	2
MST4	79	8
DYRK1A	80	2
CHK1	81	3
RIPK2	82	4
MKK6	83	4
CDK2-Cyclin A	84	1
ERK5	84	6
PIM3	84	3
MELK	85	14
PKC gamma	86	5
Src	86	7
GCK	86	54
ROCK 2	86	4
PHK	86	6
MARK3	87	43
DYRK3	87	10
PIM2	88	2
MNK1	88	10
NEK6	88	20
CAMK1	90	13
MINK1	90	8
ABL	91	12
BRSK2	91	1
PINK	92	22
SmMLCK	92	8
HIPK1	93	32
ERK1	94	1
CK1 delta	94	14
EF2K	94	2
p38 beta MAPK	96	24
BRSK1	96	25
MKK2	97	11
HIPK2	97	2
CDK9-Cyclin T1	97	7
MARK2	97	11
PKB alpha	98	11
PKD1	98	9
CK1 gamma 2	98	4
PKB beta	99	3
OSR1	99	6
MARK1	99	2
DAPK1	99	44
MAPKAP-K3	100	2
PRAK	100	4
TBK1	100	12
ERK2	100	1
HIPK3	103	15
WNK1	103	6
TLK1	103	6
p38 alpha MAPK	104	6
EPH-A4	104	1
MKK1	105	56
SRPK1	106	3
TGFBR1	107	8
TTBK1	108	1
ASK1	108	2
MAPKAP-K2	108	1
p38 gamma MAPK	110	24
PIM1	112	9
PKC zeta	113	8
MST3	115	19
TTBK2	116	2
BRK	117	6
VEGFR1	118	30
MEKK1	122	37
TrkA	135	2

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
JAK2	3	8
MLK1	6	0
EPH-A4	10	0
EPH-B1	10	2
MLK3	21	3
EPH-B4	22	3
Aurora B	23	2
IGF-1R	25	4
BTK	29	1
Aurora A	29	32
VEGFR1	31	5
EPH-A2	34	2
TrkA	35	1
PAK4	37	2
Src	41	5
ZAP70	51	0
EPH-B2	53	7
IRR	59	20
Lck	61	1
YES1	64	2
HER4	65	1
DDR2	66	1
ULK1	68	8
NUAK1	70	1
IKK epsilon	72	1
SYK	73	9
S6K1	73	7
PAK5	75	5
FGF-R1	75	8
EPH-B3	76	5
JNK3	77	1
TBK1	82	14
JNK2	85	7
SGK1	85	5
SIK3	86	9
CSK	86	19
ERK8	86	6
RSK2	87	16
AMPK (hum)	87	3
IRAK1	88	5
ULK2	88	10
PDK1	89	15
MSK1	89	2
TLK1	89	12
IRAK4	92	0
DYRK3	92	2
MST4	93	2
TSSK1	93	14
RSK1	94	24
MARK2	94	7
GSK3 beta	94	12
PDGFRA	94	13
DYRK1A	95	0
RIPK2	95	8
MARK4	95	6
BRSK2	95	1
PKD1	95	7
GCK	95	0
BRK	95	7
MINK1	95	7
ROCK 2	96	5
TTK	96	10
SIK2	96	12
p38 beta MAPK	96	14
ERK5	96	13
JNK1	97	8
STK33	97	4
EIF2AK3	97	0
IR	98	8
CAMK1	98	9
CLK2	98	11
TAO1	98	8
CHK2	98	1
MELK	98	2
MKK2	98	5
MAPKAP-K3	98	8
TESK1	99	7
PAK2	99	4
PHK	99	1
PLK1	99	6
PRK2	100	6
TIE2	100	4
ERK1	100	0
MNK2	100	6
DYRK2	101	5
DAPK1	101	7
ERK2	101	1
CAMKK beta	102	15
OSR1	102	7
PKC gamma	102	2
p38 delta MAPK	102	6
MARK3	103	8
WNK1	103	8
MST3	103	8
PIM1	103	1
PIM2	103	2
TAK1	103	23
p38 alpha MAPK	104	11
PIM3	104	10
MNK1	104	21
SRPK1	104	3
SmMLCK	105	11
NEK2a	105	1
CHK1	105	0
MKK6	105	1
EF2K	105	10
CK2	105	18
PRAK	105	11
PKC alpha	106	0
PKB alpha	107	11
MAPKAP-K2	107	5
MARK1	108	8
NEK6	108	4
MPSK1	108	6
PINK	108	3
IKK beta	109	9
MAP4K3	109	3
CK1 gamma 2	109	3
CK1 delta	109	8
MEKK1	109	1
HIPK1	109	8
HIPK2	109	3
CDK2-Cyclin A	110	9
PAK6	111	19
CDK9-Cyclin T1	111	10
PKA	111	7
ABL	112	4
BRSK1	112	1
TGFBR1	112	6
HIPK3	113	0
MKK1	113	0
MAP4K5	113	0
TTBK1	113	7
PKC zeta	115	1
LKB1	115	6
PKB beta	118	0
TTBK2	121	2
ASK1	123	1
p38 gamma MAPK	134	7
MST2	145	38

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
EPH-B1	48	1
EPH-A4	49	2
JAK2	50	6
MLK1	50	2
MLK3	58	1
Aurora B	60	3
EPH-A2	62	3
TrkA	62	0
PIM3	63	8
BTK	67	3
NUAK1	72	0
PAK4	72	8
VEGFR1	74	14
Aurora A	75	42
EPH-B4	78	9
SYK	79	0
Src	80	2
TSSK1	83	3
TLK1	84	3
DYRK3	86	3
YES1	87	4
TBK1	89	1
MKK1	89	24
p38 alpha MAPK	89	7
PAK5	90	6
EPH-B2	90	4
DDR2	91	12
IKK epsilon	91	1
PRAK	92	7
GSK3 beta	92	12
JNK2	92	5
MARK1	93	13
DYRK1A	93	23
OSR1	94	2
TIE2	94	2
PAK2	94	3
MARK3	95	2
TESK1	96	1
MSK1	96	4
PLK1	96	2
RSK1	96	14
MARK4	96	5
MEKK1	96	3
CAMK1	97	1
MARK2	97	2
CK1 delta	97	6
ZAP70	97	3
SGK1	98	7
BRK	98	7
HER4	98	3
ERK5	98	8
BRSK2	98	2
MAPKAP-K3	98	7
CSK	99	12
SIK3	99	9
ASK1	99	3
WNK1	99	6
ROCK 2	99	2
ULK2	99	9
RSK2	100	11
PRK2	100	17
MELK	100	6
DYRK2	101	1
TAO1	101	3
NEK6	101	8
PKC alpha	101	9
CK2	101	19
p38 delta MAPK	102	9
NEK2a	102	4
SRPK1	102	4
IRAK1	102	3
MAP4K3	103	5
JNK1	103	10
MNK2	103	3
BRSK1	103	0
TTBK1	103	10
CDK9-Cyclin T1	104	16
SmMLCK	104	15
MKK6	105	1
HIPK2	105	10
MST4	105	5
PKA	105	17
EIF2AK3	105	7
IRAK4	105	3
CHK2	105	1
SIK2	106	21
TTK	106	1
PIM2	106	2
GCK	106	15
PDK1	106	12
TGFBR1	106	5
Lck	107	2
ERK8	107	2
MNK1	107	7
CK1 gamma 2	107	13
RIPK2	107	10
ERK1	108	32
CDK2-Cyclin A	108	5
PINK	108	4
EPH-B3	108	0
EF2K	109	5
PKB alpha	109	13
PKD1	110	5
PKC gamma	110	0
p38 beta MAPK	112	17
AMPK (hum)	112	3
CLK2	112	6
IRR	112	18
JNK3	112	6
CHK1	112	11
ABL	113	3
PHK	113	5
MST3	114	8
DAPK1	114	4
MST2	114	6
FGF-R1	115	2
PDGFRA	115	1
S6K1	115	9
MKK2	115	1
PKB beta	116	3
STK33	116	8
IR	116	9
MINK1	116	3
MAPKAP-K2	116	3
CAMKK beta	117	13
IKK beta	117	4
HIPK3	119	13
LKB1	119	6
HIPK1	119	12
TAK1	120	24
ULK1	120	9
PKC zeta	122	7
TTBK2	122	5
PAK6	123	14
ERK2	125	7
MAP4K5	126	8
p38 gamma MAPK	129	1
PIM1	129	4
MPSK1	137	35
IGF-1R	137	19