Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Fostamatinib | C23H26FN6O9P | 580.46 | 901119-35-5 | 11671467 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 113 | 3 |
AMPK (hum) | 112 | 3 |
ASK1 | 99 | 3 |
Aurora A | 75 | 42 |
Aurora B | 60 | 3 |
BRK | 98 | 7 |
BRSK1 | 103 | 0 |
BRSK2 | 98 | 2 |
BTK | 67 | 3 |
CAMK1 | 97 | 1 |
CAMKK beta | 117 | 13 |
CDK2-Cyclin A | 108 | 5 |
CDK9-Cyclin T1 | 104 | 16 |
CHK1 | 112 | 11 |
CHK2 | 105 | 1 |
CK1 delta | 97 | 6 |
CK1 gamma 2 | 107 | 13 |
CK2 | 101 | 19 |
CLK2 | 112 | 6 |
CSK | 99 | 12 |
DAPK1 | 114 | 4 |
DDR2 | 91 | 12 |
DYRK1A | 93 | 23 |
DYRK2 | 101 | 1 |
DYRK3 | 86 | 3 |
EF2K | 109 | 5 |
EIF2AK3 | 105 | 7 |
EPH-A2 | 62 | 3 |
EPH-A4 | 49 | 2 |
EPH-B1 | 48 | 1 |
EPH-B2 | 90 | 4 |
EPH-B3 | 108 | 0 |
EPH-B4 | 78 | 9 |
ERK1 | 108 | 32 |
ERK2 | 125 | 7 |
ERK5 | 98 | 8 |
ERK8 | 107 | 2 |
FGF-R1 | 115 | 2 |
GCK | 106 | 15 |
GSK3 beta | 92 | 12 |
HER4 | 98 | 3 |
HIPK1 | 119 | 12 |
HIPK2 | 105 | 10 |
HIPK3 | 119 | 13 |
IGF-1R | 137 | 19 |
IKK beta | 117 | 4 |
IKK epsilon | 91 | 1 |
IR | 116 | 9 |
IRAK1 | 102 | 3 |
IRAK4 | 105 | 3 |
IRR | 112 | 18 |
JAK2 | 50 | 6 |
JNK1 | 103 | 10 |
JNK2 | 92 | 5 |
JNK3 | 112 | 6 |
Lck | 107 | 2 |
LKB1 | 119 | 6 |
MAP4K3 | 103 | 5 |
MAP4K5 | 126 | 8 |
MAPKAP-K2 | 116 | 3 |
MAPKAP-K3 | 98 | 7 |
MARK1 | 93 | 13 |
MARK2 | 97 | 2 |
MARK3 | 95 | 2 |
MARK4 | 96 | 5 |
MEKK1 | 96 | 3 |
MELK | 100 | 6 |
MINK1 | 116 | 3 |
MKK1 | 89 | 24 |
MKK2 | 115 | 1 |
MKK6 | 105 | 1 |
MLK1 | 50 | 2 |
MLK3 | 58 | 1 |
MNK1 | 107 | 7 |
MNK2 | 103 | 3 |
MPSK1 | 137 | 35 |
MSK1 | 96 | 4 |
MST2 | 114 | 6 |
MST3 | 114 | 8 |
MST4 | 105 | 5 |
NEK2a | 102 | 4 |
NEK6 | 101 | 8 |
NUAK1 | 72 | 0 |
OSR1 | 94 | 2 |
p38 alpha MAPK | 89 | 7 |
p38 beta MAPK | 112 | 17 |
p38 delta MAPK | 102 | 9 |
p38 gamma MAPK | 129 | 1 |
PAK2 | 94 | 3 |
PAK4 | 72 | 8 |
PAK5 | 90 | 6 |
PAK6 | 123 | 14 |
PDGFRA | 115 | 1 |
PDK1 | 106 | 12 |
PHK | 113 | 5 |
PIM1 | 129 | 4 |
PIM2 | 106 | 2 |
PIM3 | 63 | 8 |
PINK | 108 | 4 |
PKA | 105 | 17 |
PKB alpha | 109 | 13 |
PKB beta | 116 | 3 |
PKC alpha | 101 | 9 |
PKC gamma | 110 | 0 |
PKC zeta | 122 | 7 |
PKD1 | 110 | 5 |
PLK1 | 96 | 2 |
PRAK | 92 | 7 |
PRK2 | 100 | 17 |
RIPK2 | 107 | 10 |
ROCK 2 | 99 | 2 |
RSK1 | 96 | 14 |
RSK2 | 100 | 11 |
S6K1 | 115 | 9 |
SGK1 | 98 | 7 |
SIK2 | 106 | 21 |
SIK3 | 99 | 9 |
SmMLCK | 104 | 15 |
Src | 80 | 2 |
SRPK1 | 102 | 4 |
STK33 | 116 | 8 |
SYK | 79 | 0 |
TAK1 | 120 | 24 |
TAO1 | 101 | 3 |
TBK1 | 89 | 1 |
TESK1 | 96 | 1 |
TGFBR1 | 106 | 5 |
TIE2 | 94 | 2 |
TLK1 | 84 | 3 |
TrkA | 62 | 0 |
TSSK1 | 83 | 3 |
TTBK1 | 103 | 10 |
TTBK2 | 122 | 5 |
TTK | 106 | 1 |
ULK1 | 120 | 9 |
ULK2 | 99 | 9 |
VEGFR1 | 74 | 14 |
WNK1 | 99 | 6 |
YES1 | 87 | 4 |
ZAP70 | 97 | 3 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 112 | 4 |
AMPK (hum) | 87 | 3 |
ASK1 | 123 | 1 |
Aurora A | 29 | 32 |
Aurora B | 23 | 2 |
BRK | 95 | 7 |
BRSK1 | 112 | 1 |
BRSK2 | 95 | 1 |
BTK | 29 | 1 |
CAMK1 | 98 | 9 |
CAMKK beta | 102 | 15 |
CDK2-Cyclin A | 110 | 9 |
CDK9-Cyclin T1 | 111 | 10 |
CHK1 | 105 | 0 |
CHK2 | 98 | 1 |
CK1 delta | 109 | 8 |
CK1 gamma 2 | 109 | 3 |
CK2 | 105 | 18 |
CLK2 | 98 | 11 |
CSK | 86 | 19 |
DAPK1 | 101 | 7 |
DDR2 | 66 | 1 |
DYRK1A | 95 | 0 |
DYRK2 | 101 | 5 |
DYRK3 | 92 | 2 |
EF2K | 105 | 10 |
EIF2AK3 | 97 | 0 |
EPH-A2 | 34 | 2 |
EPH-A4 |
10
|
0 |
EPH-B1 |
10
|
2 |
EPH-B2 | 53 | 7 |
EPH-B3 | 76 | 5 |
EPH-B4 | 22 | 3 |
ERK1 | 100 | 0 |
ERK2 | 101 | 1 |
ERK5 | 96 | 13 |
ERK8 | 86 | 6 |
FGF-R1 | 75 | 8 |
GCK | 95 | 0 |
GSK3 beta | 94 | 12 |
HER4 | 65 | 1 |
HIPK1 | 109 | 8 |
HIPK2 | 109 | 3 |
HIPK3 | 113 | 0 |
IGF-1R | 25 | 4 |
IKK beta | 109 | 9 |
IKK epsilon | 72 | 1 |
IR | 98 | 8 |
IRAK1 | 88 | 5 |
IRAK4 | 92 | 0 |
IRR | 59 | 20 |
JAK2 |
3
|
8 |
JNK1 | 97 | 8 |
JNK2 | 85 | 7 |
JNK3 | 77 | 1 |
Lck | 61 | 1 |
LKB1 | 115 | 6 |
MAP4K3 | 109 | 3 |
MAP4K5 | 113 | 0 |
MAPKAP-K2 | 107 | 5 |
MAPKAP-K3 | 98 | 8 |
MARK1 | 108 | 8 |
MARK2 | 94 | 7 |
MARK3 | 103 | 8 |
MARK4 | 95 | 6 |
MEKK1 | 109 | 1 |
MELK | 98 | 2 |
MINK1 | 95 | 7 |
MKK1 | 113 | 0 |
MKK2 | 98 | 5 |
MKK6 | 105 | 1 |
MLK1 |
6
|
0 |
MLK3 | 21 | 3 |
MNK1 | 104 | 21 |
MNK2 | 100 | 6 |
MPSK1 | 108 | 6 |
MSK1 | 89 | 2 |
MST2 | 145 | 38 |
MST3 | 103 | 8 |
MST4 | 93 | 2 |
NEK2a | 105 | 1 |
NEK6 | 108 | 4 |
NUAK1 | 70 | 1 |
OSR1 | 102 | 7 |
p38 alpha MAPK | 104 | 11 |
p38 beta MAPK | 96 | 14 |
p38 delta MAPK | 102 | 6 |
p38 gamma MAPK | 134 | 7 |
PAK2 | 99 | 4 |
PAK4 | 37 | 2 |
PAK5 | 75 | 5 |
PAK6 | 111 | 19 |
PDGFRA | 94 | 13 |
PDK1 | 89 | 15 |
PHK | 99 | 1 |
PIM1 | 103 | 1 |
PIM2 | 103 | 2 |
PIM3 | 104 | 10 |
PINK | 108 | 3 |
PKA | 111 | 7 |
PKB alpha | 107 | 11 |
PKB beta | 118 | 0 |
PKC alpha | 106 | 0 |
PKC gamma | 102 | 2 |
PKC zeta | 115 | 1 |
PKD1 | 95 | 7 |
PLK1 | 99 | 6 |
PRAK | 105 | 11 |
PRK2 | 100 | 6 |
RIPK2 | 95 | 8 |
ROCK 2 | 96 | 5 |
RSK1 | 94 | 24 |
RSK2 | 87 | 16 |
S6K1 | 73 | 7 |
SGK1 | 85 | 5 |
SIK2 | 96 | 12 |
SIK3 | 86 | 9 |
SmMLCK | 105 | 11 |
Src | 41 | 5 |
SRPK1 | 104 | 3 |
STK33 | 97 | 4 |
SYK | 73 | 9 |
TAK1 | 103 | 23 |
TAO1 | 98 | 8 |
TBK1 | 82 | 14 |
TESK1 | 99 | 7 |
TGFBR1 | 112 | 6 |
TIE2 | 100 | 4 |
TLK1 | 89 | 12 |
TrkA | 35 | 1 |
TSSK1 | 93 | 14 |
TTBK1 | 113 | 7 |
TTBK2 | 121 | 2 |
TTK | 96 | 10 |
ULK1 | 68 | 8 |
ULK2 | 88 | 10 |
VEGFR1 | 31 | 5 |
WNK1 | 103 | 8 |
YES1 | 64 | 2 |
ZAP70 | 51 | 0 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 91 | 12 |
AMPK (hum) | 28 | 0 |
ASK1 | 108 | 2 |
Aurora A | 45 | 62 |
Aurora B | 46 | 55 |
BRK | 117 | 6 |
BRSK1 | 96 | 25 |
BRSK2 | 91 | 1 |
BTK | 15 | 0 |
CAMK1 | 90 | 13 |
CAMKK beta | 66 | 20 |
CDK2-Cyclin A | 84 | 1 |
CDK9-Cyclin T1 | 97 | 7 |
CHK1 | 81 | 3 |
CHK2 | 74 | 33 |
CK1 delta | 94 | 14 |
CK1 gamma 2 | 98 | 4 |
CK2 | 62 | 5 |
CLK2 | 39 | 0 |
CSK | 16 | 2 |
DAPK1 | 99 | 44 |
DDR2 | 14 | 5 |
DYRK1A | 80 | 2 |
DYRK2 | 74 | 7 |
DYRK3 | 87 | 10 |
EF2K | 94 | 2 |
EIF2AK3 | 55 | 4 |
EPH-A2 |
9
|
2 |
EPH-A4 | 104 | 1 |
EPH-B1 |
3
|
0 |
EPH-B2 |
6
|
1 |
EPH-B3 | 31 | 6 |
EPH-B4 | 48 | 58 |
ERK1 | 94 | 1 |
ERK2 | 100 | 1 |
ERK5 | 84 | 6 |
ERK8 | 36 | 0 |
FGF-R1 | 22 | 1 |
GCK | 86 | 54 |
GSK3 beta | 76 | 0 |
HER4 | 25 | 3 |
HIPK1 | 93 | 32 |
HIPK2 | 97 | 2 |
HIPK3 | 103 | 15 |
IGF-1R |
7
|
1 |
IKK beta | 77 | 10 |
IKK epsilon | 19 | 2 |
IR | 11 | 0 |
IRAK1 | 24 | 3 |
IRAK4 | 62 | 4 |
IRR | 18 | 0 |
JAK2 |
-5
|
12 |
JNK1 | 70 | 44 |
JNK2 | 26 | 1 |
JNK3 | 24 | 2 |
Lck |
8
|
2 |
LKB1 | 37 | 2 |
MAP4K3 | 60 | 0 |
MAP4K5 | 75 | 4 |
MAPKAP-K2 | 108 | 1 |
MAPKAP-K3 | 100 | 2 |
MARK1 | 99 | 2 |
MARK2 | 97 | 11 |
MARK3 | 87 | 43 |
MARK4 | 76 | 9 |
MEKK1 | 122 | 37 |
MELK | 85 | 14 |
MINK1 | 90 | 8 |
MKK1 | 105 | 56 |
MKK2 | 97 | 11 |
MKK6 | 83 | 4 |
MLK1 |
4
|
0 |
MLK3 |
4
|
0 |
MNK1 | 88 | 10 |
MNK2 | 71 | 4 |
MPSK1 | 66 | 8 |
MSK1 | 71 | 7 |
MST2 | 64 | 15 |
MST3 | 115 | 19 |
MST4 | 79 | 8 |
NEK2a | 58 | 1 |
NEK6 | 88 | 20 |
NUAK1 | 19 | 0 |
OSR1 | 99 | 6 |
p38 alpha MAPK | 104 | 6 |
p38 beta MAPK | 96 | 24 |
p38 delta MAPK | 71 | 6 |
p38 gamma MAPK | 110 | 24 |
PAK2 | 59 | 6 |
PAK4 |
6
|
0 |
PAK5 | 27 | 8 |
PAK6 | 64 | 6 |
PDGFRA | 73 | 66 |
PDK1 | 74 | 55 |
PHK | 86 | 6 |
PIM1 | 112 | 9 |
PIM2 | 88 | 2 |
PIM3 | 84 | 3 |
PINK | 92 | 22 |
PKA | 61 | 0 |
PKB alpha | 98 | 11 |
PKB beta | 99 | 3 |
PKC alpha | 78 | 2 |
PKC gamma | 86 | 5 |
PKC zeta | 113 | 8 |
PKD1 | 98 | 9 |
PLK1 | 55 | 4 |
PRAK | 100 | 4 |
PRK2 | 69 | 8 |
RIPK2 | 82 | 4 |
ROCK 2 | 86 | 4 |
RSK1 | 62 | 17 |
RSK2 | 78 | 35 |
S6K1 | 27 | 1 |
SGK1 | 30 | 3 |
SIK2 | 37 | 7 |
SIK3 | 72 | 9 |
SmMLCK | 92 | 8 |
Src | 86 | 7 |
SRPK1 | 106 | 3 |
STK33 | 73 | 55 |
SYK | 54 | 49 |
TAK1 | 63 | 13 |
TAO1 | 74 | 8 |
TBK1 | 100 | 12 |
TESK1 | 46 | 6 |
TGFBR1 | 107 | 8 |
TIE2 | 68 | 4 |
TLK1 | 103 | 6 |
TrkA | 135 | 2 |
TSSK1 | 43 | 0 |
TTBK1 | 108 | 1 |
TTBK2 | 116 | 2 |
TTK | 74 | 4 |
ULK1 | 16 | 0 |
ULK2 | 30 | 2 |
VEGFR1 | 118 | 30 |
WNK1 | 103 | 6 |
YES1 | 17 | 0 |
ZAP70 |
7
|
1 |