Inhibitor | Genentech LRRK2 inhibitor compound 18 (GNE-7915)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ZAP70 102 2
YES1 104 8
WNK1 103 1
VEGFR1 62 16
ULK2 92 6
ULK1 98 9
TTK 52 3
TTBK2 95 13
TTBK1 100 2
TSSK1 12 1
TrkA 81 9
TLK1 104 1
TIE2 100 6
TGFBR1 110 1
TESK1 104 15
TBK1 62 4
TAO1 111 9
TAK1 17 1
SYK 70 18
STK33 39 4
SRPK1 79 9
Src 87 0
SmMLCK 31 2
SIK3 110 8
SIK2 66 3
SGK1 72 9
S6K1 89 2
RSK2 34 5
RSK1 21 10
ROCK 2 85 4
RIPK2 86 8
PRK2 73 3
PRAK 80 14
PLK1 76 6
PKD1 46 5
PKC zeta 99 6
PKC gamma 108 5
PKC alpha 95 5
PKB beta 92 12
PKB alpha 102 9
PKA 96 2
PIM3 105 4
PIM2 100 21
PIM1 94 6
PHK 23 1
PDK1 89 1
PDGFRA 91 16
PAK6 107 5
PAK5 95 7
PAK4 92 8
PAK2 86 3
p38 gamma MAPK 99 5
p38 delta MAPK 102 3
p38 beta MAPK 98 10
p38 alpha MAPK 89 6
OSR1 99 6
NUAK1 13 2
NEK6 103 3
NEK2a 99 8
MST4 86 8
MST3 97 7
MST2 85 8
MSK1 91 8
MPSK1 97 8
MNK2 62 2
MNK1 92 11
MLK3 23 3
MLK1 25 4
MKK6 72 6
MKK2 93 14
MKK1 95 5
MINK1 115 1
MELK 90 8
MEKK1 104 5
MARK4 91 3
MARK3 80 4
MARK2 98 8
MARK1 97 5
MAPKAP-K3 91 9
MAPKAP-K2 107 11
MAP4K5 109 9
MAP4K3 69 3
LKB1 89 7
Lck 108 3
JNK3 84 12
JNK2 104 1
JNK1 87 5
JAK2 72 7
IRR 90 2
IRAK4 103 5
IRAK1 100 6
IR 19 2
IKK epsilon 78 6
IKK beta 91 16
IGF-1R 32 4
HIPK3 107 5
HIPK2 88 3
HIPK1 78 8
HER4 97 6
GSK3 beta 90 3
GCK 88 1
FGF-R1 118 7
ERK8 96 2
ERK5 65 0
ERK2 99 1
ERK1 85 3
EPH-B4 96 2
EPH-B3 106 21
EPH-B2 110 4
EPH-B1 100 5
EPH-A4 97 11
EPH-A2 107 8
EIF2AK3 99 16
EF2K 116 19
DYRK3 96 9
DYRK2 50 8
DYRK1A 85 4
DDR2 97 11
DAPK1 43 1
CSK 101 11
CLK2 50 5
CK2 95 3
CK1 gamma 2 91 1
CK1 delta 98 7
CHK2 12 4
CHK1 44 3
CDK9-Cyclin T1 96 11
CDK2-Cyclin A 102 7
CAMKK beta 28 4
CAMK1 74 5
BTK 131 3
BRSK2 80 7
BRSK1 82 5
BRK 57 4
Aurora B 55 5
Aurora A 97 13
ASK1 44 10
AMPK (hum) 71 1
AMPK 75 9
ABL 102 9
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ZAP70 79 3
YES1 104 14
WNK1 104 12
VEGFR1 13 2
ULK2 61 1
ULK1 47 8
TTK 32 7
TTBK2 74 12
TTBK1 84 6
TSSK1
3
 1
TrkA 63 18
TLK1 101 14
TIE2 85 10
TGFBR1 102 4
TESK1 98 2
TBK1 17 3
TAO1 102 12
TAK1
2
 0
SYK 33 4
STK33 22 4
SRPK1 68 0
Src 83 2
SmMLCK
6
 0
SIK3 88 5
SIK2 21 2
SGK1 59 0
S6K1 60 0
RSK2
9
 4
RSK1
8
 8
ROCK 2 72 2
RIPK2 74 9
PRK2 65 4
PRAK 55 4
PLK1 39 4
PKD1 11 0
PKC zeta 83 4
PKC gamma 95 6
PKC alpha 97 5
PKB beta 95 10
PKB alpha 87 3
PKA 86 33
PIM3 76 5
PIM2 93 0
PIM1 99 14
PHK
3
 0
PDK1 68 7
PDGFRA 61 5
PAK6 93 1
PAK5 56 2
PAK4 32 1
PAK2 86 4
p38 gamma MAPK 102 8
p38 delta MAPK 98 2
p38 beta MAPK 91 4
p38 alpha MAPK 101 4
OSR1 54 6
NUAK1
2
 0
NEK6 84 8
NEK2a 92 4
MST4 74 3
MST3 81 9
MST2 73 9
MSK1 49 7
MPSK1 96 15
MNK2 23 3
MNK1 45 1
MLK3
5
 1
MLK1
3
 0
MKK6 31 0
MKK2 90 5
MKK1 75 1
MINK1 93 10
MELK 43 2
MEKK1 99 8
MARK4 67 1
MARK3 41 1
MARK2 73 1
MARK1 58 0
MAPKAP-K3 108 13
MAPKAP-K2 85 7
MAP4K5 90 10
MAP4K3 21 1
LKB1 86 3
Lck 101 8
JNK3 50 4
JNK2 89 1
JNK1 50 3
JAK2 35 2
IRR 67 9
IRAK4 83 1
IRAK1 93 6
IR
2
 0
IKK epsilon 23 3
IKK beta 93 3
IGF-1R 38 2
HIPK3 98 12
HIPK2 65 1
HIPK1 35 5
HER4 70 3
GSK3 beta 83 3
GCK 28 1
FGF-R1 95 15
ERK8 78 8
ERK5 32 2
ERK2 71 2
ERK1 54 3
EPH-B4 87 3
EPH-B3 83 4
EPH-B2 100 3
EPH-B1 90 3
EPH-A4 76 4
EPH-A2 86 1
EIF2AK3 80 3
EF2K 107 4
DYRK3 58 5
DYRK2 17 9
DYRK1A 48 3
DDR2 98 4
DAPK1
9
 0
CSK 94 14
CLK2
9
 0
CK2 82 7
CK1 gamma 2 90 1
CK1 delta 81 7
CHK2
2
 0
CHK1 12 1
CDK9-Cyclin T1 90 7
CDK2-Cyclin A 79 9
CAMKK beta
7
 2
CAMK1 27 2
BTK 90 3
BRSK2 38 11
BRSK1 50 14
BRK 15 2
Aurora B 18 1
Aurora A 55 2
ASK1
10
 4
AMPK (hum) 29 7
AMPK 56 2
ABL 106 4