Inhibitor | Genentech LRRK2 inhibitor compound 18 (GNE-7915)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
BTK 131 3
FGF-R1 118 7
EF2K 116 19
MINK1 115 1
TAO1 111 9
SIK3 110 8
EPH-B2 110 4
TGFBR1 110 1
MAP4K5 109 9
PKC gamma 108 5
Lck 108 3
EPH-A2 107 8
HIPK3 107 5
MAPKAP-K2 107 11
PAK6 107 5
EPH-B3 106 21
PIM3 105 4
JNK2 104 1
MEKK1 104 5
TESK1 104 15
YES1 104 8
TLK1 104 1
WNK1 103 1
NEK6 103 3
IRAK4 103 5
PKB alpha 102 9
CDK2-Cyclin A 102 7
ABL 102 9
p38 delta MAPK 102 3
ZAP70 102 2
CSK 101 11
PIM2 100 21
EPH-B1 100 5
TTBK1 100 2
IRAK1 100 6
TIE2 100 6
EIF2AK3 99 16
PKC zeta 99 6
p38 gamma MAPK 99 5
NEK2a 99 8
ERK2 99 1
OSR1 99 6
ULK1 98 9
CK1 delta 98 7
p38 beta MAPK 98 10
MARK2 98 8
MPSK1 97 8
EPH-A4 97 11
MARK1 97 5
HER4 97 6
Aurora A 97 13
DDR2 97 11
MST3 97 7
EPH-B4 96 2
CDK9-Cyclin T1 96 11
DYRK3 96 9
ERK8 96 2
PKA 96 2
MKK1 95 5
PKC alpha 95 5
CK2 95 3
TTBK2 95 13
PAK5 95 7
PIM1 94 6
MKK2 93 14
ULK2 92 6
PKB beta 92 12
MNK1 92 11
PAK4 92 8
CK1 gamma 2 91 1
MSK1 91 8
MARK4 91 3
IKK beta 91 16
MAPKAP-K3 91 9
PDGFRA 91 16
GSK3 beta 90 3
IRR 90 2
MELK 90 8
PDK1 89 1
p38 alpha MAPK 89 6
S6K1 89 2
LKB1 89 7
GCK 88 1
HIPK2 88 3
Src 87 0
JNK1 87 5
PAK2 86 3
RIPK2 86 8
MST4 86 8
DYRK1A 85 4
ERK1 85 3
MST2 85 8
ROCK 2 85 4
JNK3 84 12
BRSK1 82 5
TrkA 81 9
MARK3 80 4
BRSK2 80 7
PRAK 80 14
SRPK1 79 9
HIPK1 78 8
IKK epsilon 78 6
PLK1 76 6
AMPK 75 9
CAMK1 74 5
PRK2 73 3
MKK6 72 6
SGK1 72 9
JAK2 72 7
AMPK (hum) 71 1
SYK 70 18
MAP4K3 69 3
SIK2 66 3
ERK5 65 0
MNK2 62 2
VEGFR1 62 16
TBK1 62 4
BRK 57 4
Aurora B 55 5
TTK 52 3
DYRK2 50 8
CLK2 50 5
PKD1 46 5
CHK1 44 3
ASK1 44 10
DAPK1 43 1
STK33 39 4
RSK2 34 5
IGF-1R 32 4
SmMLCK 31 2
CAMKK beta 28 4
MLK1 25 4
PHK 23 1
MLK3 23 3
RSK1 21 10
IR 19 2
TAK1 17 1
NUAK1 13 2
TSSK1 12 1
CHK2 12 4
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
MAPKAP-K3 108 13
EF2K 107 4
ABL 106 4
YES1 104 14
WNK1 104 12
TGFBR1 102 4
TAO1 102 12
p38 gamma MAPK 102 8
Lck 101 8
p38 alpha MAPK 101 4
TLK1 101 14
EPH-B2 100 3
MEKK1 99 8
PIM1 99 14
HIPK3 98 12
TESK1 98 2
p38 delta MAPK 98 2
DDR2 98 4
PKC alpha 97 5
MPSK1 96 15
PKB beta 95 10
FGF-R1 95 15
PKC gamma 95 6
CSK 94 14
IRAK1 93 6
IKK beta 93 3
PAK6 93 1
PIM2 93 0
MINK1 93 10
NEK2a 92 4
p38 beta MAPK 91 4
MKK2 90 5
BTK 90 3
EPH-B1 90 3
CDK9-Cyclin T1 90 7
CK1 gamma 2 90 1
MAP4K5 90 10
JNK2 89 1
SIK3 88 5
PKB alpha 87 3
EPH-B4 87 3
LKB1 86 3
PKA 86 33
PAK2 86 4
EPH-A2 86 1
TIE2 85 10
MAPKAP-K2 85 7
TTBK1 84 6
NEK6 84 8
Src 83 2
IRAK4 83 1
PKC zeta 83 4
GSK3 beta 83 3
EPH-B3 83 4
CK2 82 7
MST3 81 9
CK1 delta 81 7
EIF2AK3 80 3
ZAP70 79 3
CDK2-Cyclin A 79 9
ERK8 78 8
EPH-A4 76 4
PIM3 76 5
MKK1 75 1
TTBK2 74 12
RIPK2 74 9
MST4 74 3
MARK2 73 1
MST2 73 9
ROCK 2 72 2
ERK2 71 2
HER4 70 3
SRPK1 68 0
PDK1 68 7
MARK4 67 1
IRR 67 9
HIPK2 65 1
PRK2 65 4
TrkA 63 18
PDGFRA 61 5
ULK2 61 1
S6K1 60 0
SGK1 59 0
MARK1 58 0
DYRK3 58 5
AMPK 56 2
PAK5 56 2
PRAK 55 4
Aurora A 55 2
ERK1 54 3
OSR1 54 6
JNK1 50 3
JNK3 50 4
BRSK1 50 14
MSK1 49 7
DYRK1A 48 3
ULK1 47 8
MNK1 45 1
MELK 43 2
MARK3 41 1
PLK1 39 4
IGF-1R 38 2
BRSK2 38 11
HIPK1 35 5
JAK2 35 2
SYK 33 4
ERK5 32 2
PAK4 32 1
TTK 32 7
MKK6 31 0
AMPK (hum) 29 7
GCK 28 1
CAMK1 27 2
IKK epsilon 23 3
MNK2 23 3
STK33 22 4
SIK2 21 2
MAP4K3 21 1
Aurora B 18 1
DYRK2 17 9
TBK1 17 3
BRK 15 2
VEGFR1 13 2
CHK1 12 1
PKD1 11 0
ASK1
10
 4
CLK2
9
 0
DAPK1
9
 0
RSK2
9
 4
RSK1
8
 8
CAMKK beta
7
 2
SmMLCK
6
 0
MLK3
5
 1
MLK1
3
 0
PHK
3
 0
TSSK1
3
 1
TAK1
2
 0
CHK2
2
 0
IR
2
 0
NUAK1
2
 0