Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Genentech LRRK2 inhibitor compound 18 (GNE-7915) | C19H21F4N5O3 | 443.40 | LRRK2 | Estrada AA (2012) J Med Chem 55(22) 9416-33 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 102 | 9 |
AMPK | 75 | 9 |
AMPK (hum) | 71 | 1 |
ASK1 | 44 | 10 |
Aurora A | 97 | 13 |
Aurora B | 55 | 5 |
BRK | 57 | 4 |
BRSK1 | 82 | 5 |
BRSK2 | 80 | 7 |
BTK | 131 | 3 |
CAMK1 | 74 | 5 |
CAMKK beta | 28 | 4 |
CDK2-Cyclin A | 102 | 7 |
CDK9-Cyclin T1 | 96 | 11 |
CHK1 | 44 | 3 |
CHK2 | 12 | 4 |
CK1 delta | 98 | 7 |
CK1 gamma 2 | 91 | 1 |
CK2 | 95 | 3 |
CLK2 | 50 | 5 |
CSK | 101 | 11 |
DAPK1 | 43 | 1 |
DDR2 | 97 | 11 |
DYRK1A | 85 | 4 |
DYRK2 | 50 | 8 |
DYRK3 | 96 | 9 |
EF2K | 116 | 19 |
EIF2AK3 | 99 | 16 |
EPH-A2 | 107 | 8 |
EPH-A4 | 97 | 11 |
EPH-B1 | 100 | 5 |
EPH-B2 | 110 | 4 |
EPH-B3 | 106 | 21 |
EPH-B4 | 96 | 2 |
ERK1 | 85 | 3 |
ERK2 | 99 | 1 |
ERK5 | 65 | 0 |
ERK8 | 96 | 2 |
FGF-R1 | 118 | 7 |
GCK | 88 | 1 |
GSK3 beta | 90 | 3 |
HER4 | 97 | 6 |
HIPK1 | 78 | 8 |
HIPK2 | 88 | 3 |
HIPK3 | 107 | 5 |
IGF-1R | 32 | 4 |
IKK beta | 91 | 16 |
IKK epsilon | 78 | 6 |
IR | 19 | 2 |
IRAK1 | 100 | 6 |
IRAK4 | 103 | 5 |
IRR | 90 | 2 |
JAK2 | 72 | 7 |
JNK1 | 87 | 5 |
JNK2 | 104 | 1 |
JNK3 | 84 | 12 |
Lck | 108 | 3 |
LKB1 | 89 | 7 |
MAP4K3 | 69 | 3 |
MAP4K5 | 109 | 9 |
MAPKAP-K2 | 107 | 11 |
MAPKAP-K3 | 91 | 9 |
MARK1 | 97 | 5 |
MARK2 | 98 | 8 |
MARK3 | 80 | 4 |
MARK4 | 91 | 3 |
MEKK1 | 104 | 5 |
MELK | 90 | 8 |
MINK1 | 115 | 1 |
MKK1 | 95 | 5 |
MKK2 | 93 | 14 |
MKK6 | 72 | 6 |
MLK1 | 25 | 4 |
MLK3 | 23 | 3 |
MNK1 | 92 | 11 |
MNK2 | 62 | 2 |
MPSK1 | 97 | 8 |
MSK1 | 91 | 8 |
MST2 | 85 | 8 |
MST3 | 97 | 7 |
MST4 | 86 | 8 |
NEK2a | 99 | 8 |
NEK6 | 103 | 3 |
NUAK1 | 13 | 2 |
OSR1 | 99 | 6 |
p38 alpha MAPK | 89 | 6 |
p38 beta MAPK | 98 | 10 |
p38 delta MAPK | 102 | 3 |
p38 gamma MAPK | 99 | 5 |
PAK2 | 86 | 3 |
PAK4 | 92 | 8 |
PAK5 | 95 | 7 |
PAK6 | 107 | 5 |
PDGFRA | 91 | 16 |
PDK1 | 89 | 1 |
PHK | 23 | 1 |
PIM1 | 94 | 6 |
PIM2 | 100 | 21 |
PIM3 | 105 | 4 |
PKA | 96 | 2 |
PKB alpha | 102 | 9 |
PKB beta | 92 | 12 |
PKC alpha | 95 | 5 |
PKC gamma | 108 | 5 |
PKC zeta | 99 | 6 |
PKD1 | 46 | 5 |
PLK1 | 76 | 6 |
PRAK | 80 | 14 |
PRK2 | 73 | 3 |
RIPK2 | 86 | 8 |
ROCK 2 | 85 | 4 |
RSK1 | 21 | 10 |
RSK2 | 34 | 5 |
S6K1 | 89 | 2 |
SGK1 | 72 | 9 |
SIK2 | 66 | 3 |
SIK3 | 110 | 8 |
SmMLCK | 31 | 2 |
Src | 87 | 0 |
SRPK1 | 79 | 9 |
STK33 | 39 | 4 |
SYK | 70 | 18 |
TAK1 | 17 | 1 |
TAO1 | 111 | 9 |
TBK1 | 62 | 4 |
TESK1 | 104 | 15 |
TGFBR1 | 110 | 1 |
TIE2 | 100 | 6 |
TLK1 | 104 | 1 |
TrkA | 81 | 9 |
TSSK1 | 12 | 1 |
TTBK1 | 100 | 2 |
TTBK2 | 95 | 13 |
TTK | 52 | 3 |
ULK1 | 98 | 9 |
ULK2 | 92 | 6 |
VEGFR1 | 62 | 16 |
WNK1 | 103 | 1 |
YES1 | 104 | 8 |
ZAP70 | 102 | 2 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 106 | 4 |
AMPK | 56 | 2 |
AMPK (hum) | 29 | 7 |
ASK1 |
10
|
4 |
Aurora A | 55 | 2 |
Aurora B | 18 | 1 |
BRK | 15 | 2 |
BRSK1 | 50 | 14 |
BRSK2 | 38 | 11 |
BTK | 90 | 3 |
CAMK1 | 27 | 2 |
CAMKK beta |
7
|
2 |
CDK2-Cyclin A | 79 | 9 |
CDK9-Cyclin T1 | 90 | 7 |
CHK1 | 12 | 1 |
CHK2 |
2
|
0 |
CK1 delta | 81 | 7 |
CK1 gamma 2 | 90 | 1 |
CK2 | 82 | 7 |
CLK2 |
9
|
0 |
CSK | 94 | 14 |
DAPK1 |
9
|
0 |
DDR2 | 98 | 4 |
DYRK1A | 48 | 3 |
DYRK2 | 17 | 9 |
DYRK3 | 58 | 5 |
EF2K | 107 | 4 |
EIF2AK3 | 80 | 3 |
EPH-A2 | 86 | 1 |
EPH-A4 | 76 | 4 |
EPH-B1 | 90 | 3 |
EPH-B2 | 100 | 3 |
EPH-B3 | 83 | 4 |
EPH-B4 | 87 | 3 |
ERK1 | 54 | 3 |
ERK2 | 71 | 2 |
ERK5 | 32 | 2 |
ERK8 | 78 | 8 |
FGF-R1 | 95 | 15 |
GCK | 28 | 1 |
GSK3 beta | 83 | 3 |
HER4 | 70 | 3 |
HIPK1 | 35 | 5 |
HIPK2 | 65 | 1 |
HIPK3 | 98 | 12 |
IGF-1R | 38 | 2 |
IKK beta | 93 | 3 |
IKK epsilon | 23 | 3 |
IR |
2
|
0 |
IRAK1 | 93 | 6 |
IRAK4 | 83 | 1 |
IRR | 67 | 9 |
JAK2 | 35 | 2 |
JNK1 | 50 | 3 |
JNK2 | 89 | 1 |
JNK3 | 50 | 4 |
Lck | 101 | 8 |
LKB1 | 86 | 3 |
MAP4K3 | 21 | 1 |
MAP4K5 | 90 | 10 |
MAPKAP-K2 | 85 | 7 |
MAPKAP-K3 | 108 | 13 |
MARK1 | 58 | 0 |
MARK2 | 73 | 1 |
MARK3 | 41 | 1 |
MARK4 | 67 | 1 |
MEKK1 | 99 | 8 |
MELK | 43 | 2 |
MINK1 | 93 | 10 |
MKK1 | 75 | 1 |
MKK2 | 90 | 5 |
MKK6 | 31 | 0 |
MLK1 |
3
|
0 |
MLK3 |
5
|
1 |
MNK1 | 45 | 1 |
MNK2 | 23 | 3 |
MPSK1 | 96 | 15 |
MSK1 | 49 | 7 |
MST2 | 73 | 9 |
MST3 | 81 | 9 |
MST4 | 74 | 3 |
NEK2a | 92 | 4 |
NEK6 | 84 | 8 |
NUAK1 |
2
|
0 |
OSR1 | 54 | 6 |
p38 alpha MAPK | 101 | 4 |
p38 beta MAPK | 91 | 4 |
p38 delta MAPK | 98 | 2 |
p38 gamma MAPK | 102 | 8 |
PAK2 | 86 | 4 |
PAK4 | 32 | 1 |
PAK5 | 56 | 2 |
PAK6 | 93 | 1 |
PDGFRA | 61 | 5 |
PDK1 | 68 | 7 |
PHK |
3
|
0 |
PIM1 | 99 | 14 |
PIM2 | 93 | 0 |
PIM3 | 76 | 5 |
PKA | 86 | 33 |
PKB alpha | 87 | 3 |
PKB beta | 95 | 10 |
PKC alpha | 97 | 5 |
PKC gamma | 95 | 6 |
PKC zeta | 83 | 4 |
PKD1 | 11 | 0 |
PLK1 | 39 | 4 |
PRAK | 55 | 4 |
PRK2 | 65 | 4 |
RIPK2 | 74 | 9 |
ROCK 2 | 72 | 2 |
RSK1 |
8
|
8 |
RSK2 |
9
|
4 |
S6K1 | 60 | 0 |
SGK1 | 59 | 0 |
SIK2 | 21 | 2 |
SIK3 | 88 | 5 |
SmMLCK |
6
|
0 |
Src | 83 | 2 |
SRPK1 | 68 | 0 |
STK33 | 22 | 4 |
SYK | 33 | 4 |
TAK1 |
2
|
0 |
TAO1 | 102 | 12 |
TBK1 | 17 | 3 |
TESK1 | 98 | 2 |
TGFBR1 | 102 | 4 |
TIE2 | 85 | 10 |
TLK1 | 101 | 14 |
TrkA | 63 | 18 |
TSSK1 |
3
|
1 |
TTBK1 | 84 | 6 |
TTBK2 | 74 | 12 |
TTK | 32 | 7 |
ULK1 | 47 | 8 |
ULK2 | 61 | 1 |
VEGFR1 | 13 | 2 |
WNK1 | 104 | 12 |
YES1 | 104 | 14 |
ZAP70 | 79 | 3 |