Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
GSK2578215A | C24H18FN3O2 | 399.42 | LRRK2 | Reith A. (2012) Bioorg. Med. Chem. Lett. |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 97 | 4 |
AMPK | 90 | 9 |
ASK1 | 100 | 15 |
Aurora A | 100 | 5 |
Aurora B | 86 | 4 |
BRK | 103 | 0 |
BRSK1 | 93 | 1 |
BRSK2 | 91 | 9 |
BTK | 87 | 7 |
CAMK1 | 90 | 8 |
CAMKK beta | 71 | 13 |
CDK2-Cyclin A | 113 | 12 |
CDK9-Cyclin T1 | 100 | 5 |
CHK1 | 90 | 8 |
CHK2 | 89 | 8 |
CK1 delta | 107 | 4 |
CK1 gamma 2 | 81 | 2 |
CK2 | 98 | 5 |
CLK2 | 86 | 3 |
CSK | 104 | 4 |
DAPK1 | 101 | 5 |
DDR2 | 107 | 2 |
DYRK1A | 92 | 5 |
DYRK2 | 90 | 12 |
DYRK3 | 101 | 13 |
EF2K | 98 | 5 |
EIF2AK3 | 98 | 0 |
EPH-A2 | 92 | 13 |
EPH-A4 | 93 | 3 |
EPH-B1 | 89 | 5 |
EPH-B2 | 123 | 1 |
EPH-B3 | 121 | 18 |
EPH-B4 | 118 | 2 |
ERK1 | 105 | 2 |
ERK2 | 104 | 23 |
ERK8 | 99 | 10 |
FGF-R1 | 110 | 20 |
GCK | 82 | 6 |
GSK3 beta | 119 | 13 |
HER4 | 95 | 9 |
HIPK1 | 77 | 2 |
HIPK2 | 106 | 14 |
HIPK3 | 93 | 10 |
IGF-1R | 123 | 8 |
IKK beta | 92 | 11 |
IKK epsilon | 106 | 20 |
IR | 97 | 8 |
IRAK1 | 97 | 9 |
IRAK4 | 90 | 1 |
IRR | 76 | 2 |
JAK2 | 102 | 1 |
JNK1 | 91 | 1 |
JNK2 | 107 | 8 |
JNK3 | 95 | 13 |
Lck | 113 | 16 |
LKB1 | 97 | 5 |
MAPKAP-K2 | 100 | 5 |
MAPKAP-K3 | 84 | 21 |
MARK1 | 85 | 1 |
MARK2 | 89 | 16 |
MARK3 | 101 | 7 |
MARK4 | 100 | 2 |
MEKK1 | 93 | 1 |
MELK | 102 | 1 |
MINK1 | 87 | 4 |
MKK1 | 77 | 6 |
MKK2 | 85 | 11 |
MKK6 | 92 | 6 |
MLK1 | 69 | 10 |
MLK3 | 106 | 3 |
MNK1 | 88 | 8 |
MNK2 | 93 | 13 |
MPSK1 | 105 | 2 |
MSK1 | 97 | 2 |
MST2 | 103 | 28 |
MST3 | 101 | 14 |
MST4 | 94 | 11 |
NEK2a | 100 | 9 |
NEK6 | 90 | 0 |
NUAK1 | 31 | 2 |
OSR1 | 90 | 8 |
p38 alpha MAPK | 101 | 12 |
p38 beta MAPK | 104 | 25 |
p38 delta MAPK | 101 | 0 |
p38 gamma MAPK | 99 | 11 |
PAK2 | 116 | 15 |
PAK4 | 97 | 1 |
PAK5 | 95 | 3 |
PAK6 | 104 | 25 |
PDK1 | 97 | 1 |
PHK | 78 | 1 |
PIM1 | 102 | 4 |
PIM2 | 102 | 3 |
PIM3 | 103 | 11 |
PKA | 98 | 11 |
PKB alpha | 94 | 11 |
PKB beta | 95 | 2 |
PKC alpha | 93 | 4 |
PKC gamma | 93 | 13 |
PKC zeta | 96 | 17 |
PKD1 | 80 | 15 |
PLK1 | 97 | 4 |
PRAK | 109 | 4 |
PRK2 | 98 | 1 |
RIPK2 | 59 | 8 |
ROCK 2 | 82 | 10 |
RSK1 | 69 | 4 |
RSK2 | 83 | 4 |
S6K1 | 101 | 11 |
SGK1 | 89 | 10 |
SIK2 | 108 | 6 |
SIK3 | 85 | 1 |
SmMLCK | 32 | 1 |
Src | 93 | 10 |
SRPK1 | 61 | 5 |
STK33 | 64 | 5 |
SYK | 115 | 13 |
TAK1 | 108 | 13 |
TAO1 | 94 | 1 |
TBK1 | 97 | 12 |
TESK1 | 88 | 3 |
TIE2 | 119 | 19 |
TLK1 | 100 | 9 |
TrkA | 80 | 4 |
TSSK1 | 103 | 19 |
TTBK1 | 81 | 5 |
TTK | 93 | 12 |
VEGFR1 | 84 | 2 |
WNK1 | 104 | 11 |
YES1 | 120 | 2 |
ZAP70 | 103 | 3 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 86 | 14 |
AMPK | 83 | 1 |
ASK1 | 92 | 23 |
Aurora A | 94 | 9 |
Aurora B | 86 | 5 |
BRK | 101 | 13 |
BRSK1 | 97 | 5 |
BRSK2 | 97 | 11 |
BTK | 86 | 4 |
CAMK1 | 88 | 11 |
CAMKK beta | 96 | 9 |
CDK2-Cyclin A | 117 | 2 |
CDK9-Cyclin T1 | 103 | 17 |
CHK1 | 102 | 13 |
CHK2 | 90 | 2 |
CK1 delta | 82 | 3 |
CK1 gamma 2 | 77 | 1 |
CK2 | 93 | 2 |
CLK2 | 86 | 3 |
CSK | 114 | 22 |
DAPK1 | 95 | 9 |
DDR2 | 100 | 15 |
DYRK1A | 104 | 21 |
DYRK2 | 92 | 1 |
DYRK3 | 85 | 16 |
EF2K | 93 | 10 |
EIF2AK3 | 97 | 9 |
EPH-A2 | 104 | 4 |
EPH-A4 | 86 | 3 |
EPH-B1 | 95 | 28 |
EPH-B2 | 115 | 21 |
EPH-B3 | 113 | 4 |
EPH-B4 | 108 | 13 |
ERK1 | 97 | 0 |
ERK2 | 115 | 1 |
ERK8 | 99 | 9 |
FGF-R1 | 93 | 8 |
GCK | 89 | 3 |
GSK3 beta | 96 | 3 |
HER4 | 84 | 9 |
HIPK1 | 81 | 28 |
HIPK2 | 107 | 8 |
HIPK3 | 85 | 9 |
IGF-1R | 117 | 13 |
IKK beta | 101 | 13 |
IKK epsilon | 102 | 1 |
IR | 102 | 8 |
IRAK1 | 91 | 8 |
IRAK4 | 91 | 9 |
IRR | 96 | 3 |
JAK2 | 91 | 1 |
JNK1 | 93 | 0 |
JNK2 | 86 | 7 |
JNK3 | 94 | 3 |
Lck | 90 | 33 |
LKB1 | 105 | 1 |
MAPKAP-K2 | 96 | 9 |
MAPKAP-K3 | 82 | 0 |
MARK1 | 88 | 8 |
MARK2 | 95 | 10 |
MARK3 | 98 | 1 |
MARK4 | 92 | 0 |
MEKK1 | 90 | 4 |
MELK | 93 | 17 |
MINK1 | 76 | 17 |
MKK1 | 98 | 5 |
MKK2 | 84 | 23 |
MKK6 | 91 | 4 |
MLK1 | 92 | 14 |
MLK3 | 99 | 3 |
MNK1 | 88 | 14 |
MNK2 | 98 | 7 |
MPSK1 | 102 | 3 |
MSK1 | 120 | 3 |
MST2 | 92 | 11 |
MST3 | 84 | 32 |
MST4 | 94 | 8 |
NEK2a | 97 | 16 |
NEK6 | 65 | 13 |
NUAK1 | 58 | 11 |
OSR1 | 95 | 6 |
p38 alpha MAPK | 102 | 6 |
p38 beta MAPK | 98 | 1 |
p38 delta MAPK | 95 | 3 |
p38 gamma MAPK | 98 | 7 |
PAK2 | 87 | 27 |
PAK4 | 94 | 7 |
PAK5 | 100 | 3 |
PAK6 | 98 | 2 |
PDK1 | 91 | 10 |
PHK | 75 | 7 |
PIM1 | 109 | 7 |
PIM2 | 100 | 12 |
PIM3 | 100 | 6 |
PKA | 95 | 10 |
PKB alpha | 96 | 7 |
PKB beta | 85 | 7 |
PKC alpha | 94 | 5 |
PKC gamma | 84 | 11 |
PKC zeta | 96 | 3 |
PKD1 | 76 | 8 |
PLK1 | 90 | 2 |
PRAK | 114 | 14 |
PRK2 | 79 | 7 |
RIPK2 | 56 | 9 |
ROCK 2 | 85 | 4 |
RSK1 | 82 | 7 |
RSK2 | 81 | 0 |
S6K1 | 96 | 4 |
SGK1 | 96 | 3 |
SIK2 | 111 | 3 |
SIK3 | 101 | 0 |
SmMLCK | 23 | 1 |
Src | 160 | 3 |
SRPK1 | 69 | 17 |
STK33 | 66 | 4 |
SYK | 125 | 7 |
TAK1 | 101 | 1 |
TAO1 | 92 | 6 |
TBK1 | 88 | 9 |
TESK1 | 96 | 8 |
TIE2 | 133 | 9 |
TLK1 | 93 | 3 |
TrkA | 90 | 9 |
TSSK1 | 92 | 7 |
TTBK1 | 98 | 5 |
TTK | 96 | 5 |
VEGFR1 | 83 | 11 |
WNK1 | 106 | 8 |
YES1 | 140 | 37 |
ZAP70 | 92 | 11 |