Inhibitor |
BMS345541 (IKK Inhibitor III)
Screening Results Tables
Screen Conc:
1.00µM
Kinase |
% Activity Remaining |
Standard Deviation |
AMPK
|
97
|
4
|
Aurora A
|
117
|
6
|
Aurora B
|
107
|
35
|
BRSK1
|
102
|
8
|
BRSK2
|
103
|
6
|
BTK
|
105
|
17
|
CAMK1
|
85
|
26
|
CAMKK beta
|
105
|
1
|
CDK2-Cyclin A
|
97
|
9
|
CHK1
|
129
|
19
|
CHK2
|
121
|
7
|
CK1 delta
|
104
|
19
|
CK2
|
116
|
8
|
CLK2
|
102
|
12
|
CSK
|
135
|
1
|
DAPK1
|
109
|
8
|
DYRK1A
|
108
|
2
|
DYRK2
|
89
|
8
|
DYRK3
|
107
|
1
|
EF2K
|
117
|
12
|
EPH-A2
|
98
|
11
|
EPH-A4
|
103
|
7
|
EPH-B2
|
126
|
9
|
EPH-B3
|
97
|
5
|
EPH-B4
|
111
|
9
|
ERK1
|
121
|
7
|
ERK2
|
116
|
23
|
ERK8
|
93
|
5
|
FGF-R1
|
103
|
12
|
GCK
|
110
|
3
|
GSK3 beta
|
102
|
19
|
HER4
|
145
|
13
|
HIPK1
|
101
|
9
|
HIPK2
|
98
|
3
|
HIPK3
|
106
|
4
|
IGF-1R
|
81
|
3
|
IKK beta
|
57
|
2
|
IKK epsilon
|
119
|
13
|
IR
|
109
|
1
|
IRAK4
|
127
|
19
|
IRR
|
94
|
3
|
JAK2
|
111
|
12
|
JNK1
|
111
|
19
|
JNK2
|
116
|
2
|
JNK3
|
104
|
20
|
Lck
|
109
|
9
|
LKB1
|
99
|
6
|
MAPKAP-K2
|
111
|
3
|
MAPKAP-K3
|
129
|
15
|
MARK1
|
109
|
2
|
MARK2
|
118
|
6
|
MARK3
|
97
|
11
|
MARK4
|
107
|
3
|
MEKK1
|
101
|
2
|
MELK
|
103
|
5
|
MINK1
|
117
|
25
|
MKK1
|
113
|
10
|
MLK1
|
104
|
34
|
MLK3
|
123
|
16
|
MNK1
|
97
|
22
|
MNK2
|
119
|
3
|
MSK1
|
93
|
7
|
MST2
|
86
|
8
|
MST4
|
94
|
1
|
NEK2a
|
117
|
3
|
NEK6
|
105
|
0
|
NUAK1
|
97
|
5
|
p38 alpha MAPK
|
113
|
16
|
p38 beta MAPK
|
100
|
4
|
p38 delta MAPK
|
101
|
2
|
p38 gamma MAPK
|
114
|
9
|
PAK2
|
113
|
9
|
PAK4
|
139
|
28
|
PAK5
|
139
|
14
|
PAK6
|
103
|
11
|
PDK1
|
107
|
2
|
PHK
|
109
|
3
|
PIM1
|
105
|
1
|
PIM2
|
113
|
1
|
PIM3
|
87
|
4
|
PKA
|
112
|
6
|
PKB alpha
|
92
|
0
|
PKB beta
|
117
|
14
|
PKC alpha
|
96
|
13
|
PKC zeta
|
124
|
2
|
PKD1
|
110
|
7
|
PLK1
|
111
|
9
|
PRAK
|
93
|
8
|
PRK2
|
116
|
8
|
RIPK2
|
102
|
4
|
ROCK 2
|
110
|
2
|
RSK1
|
97
|
3
|
RSK2
|
109
|
5
|
S6K1
|
105
|
1
|
SGK1
|
102
|
17
|
SmMLCK
|
110
|
7
|
Src
|
135
|
27
|
SRPK1
|
111
|
3
|
SYK
|
97
|
1
|
TAK1
|
105
|
10
|
TBK1
|
111
|
2
|
TrkA
|
169
|
18
|
TTK
|
102
|
8
|
VEGFR1
|
94
|
4
|
YES1
|
115
|
7
|
Screen Conc:
10.00µM
Kinase |
% Activity Remaining |
Standard Deviation |
AMPK
|
91
|
1
|
Aurora A
|
108
|
3
|
Aurora B
|
64
|
7
|
BRSK1
|
89
|
21
|
BRSK2
|
84
|
4
|
BTK
|
98
|
15
|
CAMK1
|
73
|
8
|
CAMKK beta
|
99
|
1
|
CDK2-Cyclin A
|
60
|
4
|
CHK1
|
86
|
3
|
CHK2
|
88
|
2
|
CK1 delta
|
55
|
5
|
CK2
|
79
|
1
|
CLK2
|
74
|
3
|
CSK
|
93
|
6
|
DAPK1
|
118
|
45
|
DYRK1A
|
77
|
3
|
DYRK2
|
46
|
0
|
DYRK3
|
71
|
2
|
EF2K
|
99
|
3
|
EPH-A2
|
65
|
0
|
EPH-A4
|
83
|
1
|
EPH-B2
|
92
|
12
|
EPH-B3
|
61
|
1
|
EPH-B4
|
132
|
13
|
ERK1
|
87
|
6
|
ERK2
|
97
|
2
|
ERK8
|
18
|
2
|
FGF-R1
|
73
|
18
|
GCK
|
87
|
5
|
GSK3 beta
|
82
|
7
|
HER4
|
105
|
9
|
HIPK1
|
96
|
14
|
HIPK2
|
67
|
1
|
HIPK3
|
96
|
9
|
IGF-1R
|
93
|
2
|
IKK beta
|
16
|
6
|
IKK epsilon
|
101
|
8
|
IR
|
109
|
1
|
IRAK4
|
97
|
7
|
IRR
|
76
|
3
|
JAK2
|
87
|
2
|
JNK1
|
101
|
0
|
JNK2
|
83
|
2
|
JNK3
|
81
|
3
|
Lck
|
79
|
4
|
LKB1
|
71
|
8
|
MAPKAP-K2
|
100
|
3
|
MAPKAP-K3
|
94
|
3
|
MARK1
|
110
|
3
|
MARK2
|
103
|
5
|
MARK3
|
109
|
11
|
MARK4
|
103
|
10
|
MEKK1
|
92
|
3
|
MELK
|
94
|
13
|
MINK1
|
93
|
7
|
MKK1
|
96
|
3
|
MLK1
|
89
|
6
|
MLK3
|
91
|
2
|
MNK1
|
88
|
3
|
MNK2
|
100
|
6
|
MSK1
|
82
|
2
|
MST2
|
92
|
7
|
MST4
|
89
|
5
|
NEK2a
|
90
|
7
|
NEK6
|
86
|
7
|
NUAK1
|
45
|
5
|
p38 alpha MAPK
|
101
|
3
|
p38 beta MAPK
|
101
|
2
|
p38 delta MAPK
|
91
|
3
|
p38 gamma MAPK
|
102
|
3
|
PAK2
|
110
|
1
|
PAK4
|
106
|
7
|
PAK5
|
97
|
7
|
PAK6
|
96
|
7
|
PDK1
|
98
|
6
|
PHK
|
88
|
4
|
PIM1
|
95
|
2
|
PIM2
|
83
|
5
|
PIM3
|
70
|
3
|
PKA
|
94
|
4
|
PKB alpha
|
88
|
5
|
PKB beta
|
103
|
1
|
PKC alpha
|
90
|
4
|
PKC zeta
|
102
|
8
|
PKD1
|
54
|
5
|
PLK1
|
116
|
2
|
PRAK
|
111
|
7
|
PRK2
|
100
|
3
|
RIPK2
|
113
|
19
|
ROCK 2
|
80
|
5
|
RSK1
|
101
|
2
|
RSK2
|
81
|
8
|
S6K1
|
83
|
3
|
SGK1
|
91
|
4
|
SmMLCK
|
77
|
2
|
Src
|
90
|
7
|
SRPK1
|
104
|
4
|
SYK
|
96
|
1
|
TAK1
|
101
|
13
|
TBK1
|
89
|
9
|
TrkA
|
99
|
8
|
TTK
|
85
|
4
|
VEGFR1
|
69
|
2
|
YES1
|
84
|
12
|