Inhibitor | CP-690550 (Tasocitinib)  

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
JAK2	3	1
PRK2	22	0
Lck	30	0
NUAK1	30	2
MARK3	33	4
FGF-R1	42	4
ROCK 2	46	9
VEGFR1	58	10
MARK1	63	1
MST2	64	12
MNK2	64	10
YES1	65	4
MKK1	67	6
Aurora B	69	6
CDK2-Cyclin A	69	4
PKC alpha	71	0
BRSK1	73	2
MELK	74	5
MLK3	75	1
MSK1	76	15
RSK1	76	23
S6K1	77	16
BRK	80	18
IRAK4	80	1
JNK1	81	5
BRSK2	82	5
MEKK1	83	80
MPSK1	83	14
AMPK	83	1
TBK1	83	19
CSK	84	7
MARK2	85	4
PHK	85	11
MARK4	86	1
CHK1	86	13
RSK2	86	2
GCK	87	0
IR	87	8
TrkA	87	11
JNK2	88	9
MKK6	89	2
SRPK1	89	8
PKA	89	1
Src	90	7
IKK epsilon	90	7
MINK1	90	9
MLK1	90	8
HIPK1	90	4
NEK6	90	5
EPH-B2	91	10
MAPKAP-K2	91	11
PKB beta	92	6
CK2	92	1
RIPK2	92	3
CAMK1	93	1
Aurora A	93	8
EPH-B1	93	4
OSR1	94	12
PAK5	94	4
LKB1	95	5
BTK	96	6
ERK2	99	17
DYRK2	99	14
PIM1	101	8
IRR	102	3
PKC zeta	102	5
DYRK1A	102	1
ABL	103	13
EF2K	103	1
TAO1	103	4
p38 alpha MAPK	103	4
STK33	103	19
EPH-B3	103	8
SmMLCK	104	3
TLK1	104	8
CK1 delta	105	4
ASK1	105	7
SGK1	106	19
PKC gamma	106	20
CHK2	106	7
TIE2	106	19
PKD1	106	27
CLK2	106	10
EPH-A2	106	6
JNK3	107	10
NEK2a	107	32
ERK1	108	5
p38 delta MAPK	108	17
MST4	109	0
IGF-1R	109	9
HIPK3	109	14
GSK3 beta	110	2
DYRK3	110	18
IRAK1	111	4
MKK2	112	20
TAK1	113	34
PIM3	114	9
EIF2AK3	114	8
PAK2	114	2
p38 beta MAPK	115	3
MNK1	115	0
TTK	115	7
HER4	116	8
PAK4	116	16
PAK6	116	10
MAPKAP-K3	118	7
PIM2	121	21
ERK8	121	1
PLK1	121	18
EPH-A4	121	2
PRAK	123	7
PDK1	123	3
PKB alpha	125	4
ZAP70	125	3
IKK beta	126	3
HIPK2	128	21
p38 gamma MAPK	130	9
EPH-B4	131	46
CAMKK beta	139	15
DAPK1	145	5
SYK	152	16

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
JAK2	4	0
PRK2	50	2
Lck	73	9
NUAK1	74	5
CSK	78	3
MST2	79	7
JNK1	80	3
MAPKAP-K2	82	7
MARK1	82	10
MSK1	83	10
MLK3	83	12
SRPK1	84	6
EPH-B3	85	5
PKB beta	85	9
FGF-R1	85	3
PAK5	86	7
MLK1	86	5
IRAK4	87	0
NEK6	87	3
IKK epsilon	87	8
MST4	87	8
S6K1	88	0
CHK1	88	1
RIPK2	91	9
RSK2	91	3
MAPKAP-K3	91	4
PKD1	92	4
DYRK1A	92	7
Aurora B	92	8
BRK	92	7
Src	92	5
SGK1	92	2
BRSK1	92	7
EPH-B1	93	4
MARK4	93	2
MPSK1	94	10
MARK3	94	16
PKA	94	4
JNK2	94	4
BTK	94	11
CHK2	95	9
AMPK	95	5
ROCK 2	95	15
RSK1	96	6
MINK1	96	7
PHK	96	2
PKC alpha	96	0
EIF2AK3	97	9
CK2	97	7
MNK2	97	2
MKK6	97	8
ERK1	97	4
ERK2	97	10
MEKK1	97	7
STK33	98	4
MARK2	98	1
PKC zeta	99	11
TIE2	99	1
PAK2	99	2
TTK	99	3
TBK1	99	6
VEGFR1	99	5
p38 alpha MAPK	100	1
PKC gamma	100	21
MNK1	100	11
TLK1	100	3
PAK6	100	3
EF2K	100	2
p38 delta MAPK	101	7
LKB1	101	9
BRSK2	101	3
NEK2a	102	16
PIM2	102	5
DYRK2	103	5
IRR	103	5
TAO1	104	12
PAK4	104	10
IGF-1R	104	11
YES1	104	3
MKK1	105	6
IKK beta	105	2
SmMLCK	105	3
IR	105	9
p38 beta MAPK	106	12
IRAK1	106	3
TrkA	106	13
PDK1	107	14
GSK3 beta	108	9
HIPK3	108	3
CLK2	108	1
CK1 delta	109	9
EPH-A4	109	3
GCK	109	7
MKK2	110	3
CAMK1	111	2
HIPK1	112	4
OSR1	112	9
PIM1	112	5
PRAK	113	10
EPH-A2	114	19
p38 gamma MAPK	115	6
TAK1	115	7
PKB alpha	115	1
MELK	115	12
CDK2-Cyclin A	116	37
DYRK3	116	2
CAMKK beta	116	10
ABL	116	10
HIPK2	117	6
Aurora A	119	16
JNK3	119	12
EPH-B4	120	4
ERK8	121	6
EPH-B2	121	12
HER4	121	19
DAPK1	123	11
PIM3	124	12
PLK1	128	7
ASK1	130	11
SYK	131	7
ZAP70	133	0