Inhibitor | LFM-A13  

Screen Conc: 100.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
PIM1	3	0
PIM3	3	0
GSK3 beta	7	1
HIPK2	7	2
DYRK2	7	1
CK2	9	1
DYRK3	10	0
CLK2	10	1
DAPK1	12	0
PIM2	18	1
ERK8	19	0
ROCK 2	21	1
MKK2	22	6
BTK	23	3
IRAK4	23	2
PRK2	23	4
CHK2	24	4
TrkA	27	6
MSK1	27	10
S6K1	28	0
MLK1	28	2
VEGFR1	29	6
MLK3	29	3
IRAK1	30	1
MKK1	34	1
HIPK1	34	2
STK33	34	0
RSK1	37	7
MNK2	37	9
PAK4	37	2
SmMLCK	39	1
TTK	40	2
JNK3	41	3
IR	42	4
BRK	43	2
BRSK2	44	6
DYRK1A	44	4
MST4	45	1
GCK	46	2
IGF-1R	46	6
HER4	47	5
Aurora A	47	2
IRR	48	7
JAK2	48	4
MARK4	48	12
PHK	49	3
CK1 delta	49	10
HIPK3	50	16
NUAK1	52	3
MAPKAP-K3	53	16
SGK1	53	4
EIF2AK3	53	2
MARK1	55	6
MST2	55	5
BRSK1	56	2
CAMKK beta	57	7
JNK2	57	4
LKB1	58	12
PKD1	58	9
ASK1	59	0
PKB beta	59	7
PDK1	60	0
JNK1	60	14
CDK2-Cyclin A	60	1
EPH-A2	61	2
RSK2	63	1
PRAK	63	13
EPH-B2	63	5
SYK	64	4
TBK1	64	13
ERK2	64	2
AMPK	65	5
PKA	66	11
MARK3	67	5
PAK2	68	2
TAK1	69	1
MAPKAP-K2	70	0
PKC zeta	71	10
PLK1	71	0
TAO1	72	3
MINK1	72	3
Src	72	3
EPH-A4	73	8
SRPK1	74	0
FGF-R1	74	14
MNK1	75	3
p38 beta MAPK	75	8
EPH-B1	76	1
TIE2	77	4
MEKK1	77	3
OSR1	77	4
MELK	77	3
PKB alpha	78	6
PAK5	79	10
RIPK2	80	4
p38 gamma MAPK	81	0
MPSK1	82	11
EPH-B3	83	6
CAMK1	85	5
CSK	85	14
IKK epsilon	86	7
MARK2	87	9
EF2K	87	9
EPH-B4	89	15
IKK beta	90	4
YES1	92	10
PKC alpha	94	11
p38 delta MAPK	95	7
NEK6	96	7
ERK1	100	11
PKC gamma	104	13
Lck	105	2
TLK1	106	5
p38 alpha MAPK	109	2
ABL	110	31
PAK6	110	12
MKK6	110	23
ZAP70	113	1
NEK2a	114	4
Aurora B	162	28
CHK1	207	9

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
PIM3	10	3
PIM1	18	0
GSK3 beta	29	1
HIPK2	31	1
DYRK2	34	4
CK2	45	1
MELK	45	3
CLK2	47	1
MSK1	47	11
MKK2	48	2
DAPK1	54	11
BTK	56	8
DYRK3	56	5
BRK	58	38
IRAK1	63	1
STK33	64	1
MKK1	67	4
PKB beta	67	11
IRAK4	68	3
ROCK 2	68	4
TrkA	69	1
NUAK1	69	9
CAMKK beta	69	5
TTK	69	4
PIM2	70	8
TBK1	71	0
MST2	71	6
LKB1	72	6
IR	72	10
JNK3	73	2
MPSK1	73	16
MLK1	74	8
PRK2	74	5
MLK3	74	19
CHK2	75	1
VEGFR1	75	1
RSK2	76	9
PAK4	76	6
JNK1	76	1
JNK2	76	9
BRSK2	76	5
PHK	77	10
RSK1	78	5
MAPKAP-K2	78	2
ERK2	79	1
SRPK1	82	0
PAK5	82	2
MAPKAP-K3	83	7
GCK	83	3
MARK1	83	2
SmMLCK	84	2
AMPK	84	7
PAK2	84	12
BRSK1	84	9
PKA	85	4
ERK8	85	6
DYRK1A	85	7
PKC gamma	86	1
CHK1	87	6
NEK2a	88	7
MNK2	89	3
S6K1	90	13
EPH-A4	90	3
HIPK3	90	3
IGF-1R	90	10
EPH-B1	91	1
Lck	91	5
NEK6	91	14
IKK beta	92	15
HIPK1	92	17
MINK1	92	1
RIPK2	92	4
EPH-B2	92	13
FGF-R1	92	8
HER4	93	3
EIF2AK3	94	5
IRR	94	3
ERK1	94	7
CDK2-Cyclin A	94	6
p38 gamma MAPK	94	3
EPH-A2	95	8
p38 alpha MAPK	95	1
MST4	95	11
TAK1	95	11
p38 beta MAPK	96	2
PKC zeta	96	0
p38 delta MAPK	97	5
Aurora B	98	0
PRAK	98	5
MKK6	98	13
CK1 delta	98	7
MARK2	98	28
JAK2	99	4
PDK1	99	15
EF2K	99	7
SGK1	100	4
MEKK1	100	19
CSK	100	1
YES1	101	1
SYK	102	9
PKB alpha	102	10
PKC alpha	103	3
Aurora A	104	11
TLK1	104	11
Src	104	6
MARK4	105	14
PAK6	105	0
ABL	105	6
IKK epsilon	106	5
OSR1	106	11
MNK1	106	4
ASK1	107	5
PKD1	108	13
ZAP70	108	12
EPH-B4	108	6
EPH-B3	110	7
MARK3	110	3
CAMK1	111	14
TIE2	119	4
PLK1	120	21
TAO1	123	20

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IGF-1R	47	5
MKK1	55	15
PIM1	58	12
PIM3	60	4
BRSK2	63	7
MELK	63	3
CK2	68	14
CHK1	68	2
PRAK	70	0
CAMK1	70	6
MSK1	71	6
NEK6	72	0
DYRK3	74	2
CSK	77	3
MAPKAP-K2	77	1
GSK3 beta	78	14
DYRK2	78	3
Src	78	2
SGK1	79	9
IRR	80	5
RSK2	80	6
CAMKK beta	80	6
PDK1	81	14
MST2	81	4
PIM2	83	2
DYRK1A	83	3
PAK4	83	3
PAK5	83	8
PAK6	83	6
CDK2-Cyclin A	83	0
MNK2	83	9
MARK3	84	20
TBK1	84	1
PKC alpha	84	4
IKK epsilon	85	3
ERK8	86	7
SmMLCK	86	4
S6K1	86	3
SRPK1	86	17
PKC zeta	86	2
ERK1	87	2
p38 alpha MAPK	88	1
HIPK2	88	7
EPH-A2	88	4
p38 delta MAPK	88	4
ROCK 2	89	7
FGF-R1	89	4
p38 beta MAPK	90	11
SYK	90	1
PRK2	91	2
MNK1	91	6
PKD1	92	15
PKA	92	1
RSK1	93	4
IR	94	28
EPH-B3	94	13
ERK2	94	0
Lck	95	5
EF2K	97	2
CK1 delta	97	4
JNK2	98	3
IKK beta	98	3
CHK2	98	3
p38 gamma MAPK	99	5
AMPK	99	3
JNK1	100	0
PLK1	100	4
PKB alpha	101	4
YES1	102	3
BTK	103	0
PHK	103	2
NEK2a	108	13
PKB beta	110	27
MST4	112	22
VEGFR1	120	8