Inhibitor | BI605906 (BIX02514)  

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IKK beta	16	2
IRR	57	1
IGF-1R	62	7
PIM3	74	9
PRAK	75	16
MNK1	76	8
RIPK2	76	2
IR	80	1
CK1 delta	80	2
PDK1	81	4
FGF-R1	82	2
PIM1	82	4
DYRK3	82	1
p38 alpha MAPK	83	0
CK2	84	14
IRAK1	84	9
MARK2	85	2
JNK1	85	5
p38 gamma MAPK	85	0
PKB alpha	85	14
SmMLCK	86	6
ROCK 2	86	10
DAPK1	86	9
GCK	87	3
PRK2	87	5
PKC alpha	87	2
PKC zeta	87	5
PKA	88	3
VEGFR1	88	0
CDK2-Cyclin A	88	6
CAMKK beta	89	13
YES1	89	12
MST2	90	1
PAK4	90	6
MINK1	91	0
TLK1	91	13
ASK1	92	4
MAPKAP-K3	92	9
JAK2	93	13
NUAK1	93	14
p38 beta MAPK	93	4
MARK1	94	15
JNK3	94	9
AMPK	94	8
HER4	95	8
MARK3	96	8
PIM2	96	2
HIPK3	96	7
IRAK4	96	6
Aurora B	96	4
MKK2	97	13
NEK2a	97	3
IKK epsilon	98	14
CAMK1	98	6
MLK1	98	8
STK33	98	6
DYRK2	98	11
OSR1	98	4
MST4	99	3
S6K1	99	5
TTK	99	7
EPH-B4	100	10
HIPK2	100	13
DYRK1A	100	6
SGK1	101	10
CHK1	101	2
MAPKAP-K2	101	18
ABL	102	10
SRPK1	102	1
ERK8	102	7
MSK1	102	4
CLK2	102	1
PAK5	102	8
EPH-B2	102	7
TBK1	103	15
ZAP70	103	1
PLK1	103	2
BRK	103	2
MKK6	104	2
Lck	104	2
MELK	104	0
CHK2	104	2
ERK2	105	2
PHK	105	4
BRSK1	105	7
EF2K	105	7
p38 delta MAPK	105	2
PAK2	105	5
Src	106	11
HIPK1	106	10
EPH-A2	106	6
LKB1	106	5
ERK1	108	8
MARK4	108	12
BTK	108	1
SYK	108	3
GSK3 beta	108	5
TIE2	108	2
JNK2	109	2
EIF2AK3	109	4
TAK1	109	8
MNK2	109	3
BRSK2	110	12
EPH-A4	110	5
CSK	112	6
Aurora A	112	6
RSK1	113	12
RSK2	113	10
PAK6	113	2
MPSK1	113	6
MLK3	114	12
EPH-B1	114	8
TrkA	115	11
EPH-B3	117	8
PKB beta	120	10
MKK1	120	8
PKD1	123	2
TAO1	124	13
MEKK1	126	4
PKC gamma	130	7
NEK6	130	0

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IKK beta	33	0
IKK epsilon	75	3
ERK1	78	3
JNK1	78	15
CK1 delta	78	0
IRAK1	80	1
Src	81	4
GCK	81	4
MARK4	81	11
NUAK1	81	10
VEGFR1	81	3
JAK2	83	0
ERK8	84	9
MARK1	84	3
MST2	84	11
IRR	84	1
PKA	84	7
PDK1	85	12
MAPKAP-K3	85	6
MINK1	85	12
PIM3	85	3
S6K1	85	5
CK2	86	5
STK33	86	0
SYK	86	11
TIE2	87	1
PKC zeta	87	5
DYRK3	87	4
PIM2	87	4
MKK6	87	8
MNK1	88	6
SmMLCK	88	5
EPH-A2	89	3
PKB alpha	89	5
SGK1	89	5
BRSK2	89	8
TAO1	89	4
PKD1	90	1
ERK2	90	5
HIPK2	91	4
p38 alpha MAPK	91	6
MARK2	91	11
CHK1	91	11
p38 gamma MAPK	92	5
CDK2-Cyclin A	92	0
p38 delta MAPK	92	4
PAK5	92	7
LKB1	92	4
MST4	92	11
AMPK	92	15
IGF-1R	92	1
ABL	92	12
BTK	92	9
PAK4	93	10
PAK6	93	3
MKK2	93	6
CAMKK beta	93	12
PLK1	94	4
MPSK1	94	0
TLK1	94	10
MARK3	94	7
ASK1	94	8
PKC alpha	94	3
EPH-B4	95	1
CAMK1	95	7
SRPK1	95	13
MLK1	95	1
JNK2	95	1
CHK2	96	3
HIPK3	96	3
p38 beta MAPK	96	13
GSK3 beta	96	7
DYRK2	96	1
PAK2	96	4
RIPK2	96	7
EPH-B1	96	5
TTK	96	11
PIM1	96	11
BRSK1	96	4
EF2K	96	9
MLK3	96	1
EPH-A4	97	3
EPH-B2	97	4
MNK2	97	4
HER4	97	2
IR	97	4
DAPK1	97	13
HIPK1	97	7
IRAK4	98	7
NEK2a	98	10
OSR1	98	9
Aurora B	98	10
FGF-R1	98	7
CSK	98	13
PRK2	98	3
BRK	99	2
TAK1	100	1
DYRK1A	100	2
CLK2	100	4
TBK1	100	21
PKB beta	100	1
ROCK 2	100	4
PKC gamma	101	8
EPH-B3	101	6
PRAK	101	6
PHK	101	3
ZAP70	102	8
NEK6	104	1
RSK2	104	8
EIF2AK3	104	11
Aurora A	106	9
MELK	106	5
Lck	108	10
YES1	108	6
MAPKAP-K2	109	9
TrkA	109	2
MKK1	110	11
RSK1	112	6
MSK1	115	14
MEKK1	115	1
JNK3	118	7