Inhibitor |
BI605906 (BIX02514)
Screening Results Tables
Screen Conc:
0.10µM
Kinase |
% Activity Remaining |
Standard Deviation |
ABL
|
92
|
12
|
AMPK
|
92
|
15
|
ASK1
|
94
|
8
|
Aurora A
|
106
|
9
|
Aurora B
|
98
|
10
|
BRK
|
99
|
2
|
BRSK1
|
96
|
4
|
BRSK2
|
89
|
8
|
BTK
|
92
|
9
|
CAMK1
|
95
|
7
|
CAMKK beta
|
93
|
12
|
CDK2-Cyclin A
|
92
|
0
|
CHK1
|
91
|
11
|
CHK2
|
96
|
3
|
CK1 delta
|
78
|
0
|
CK2
|
86
|
5
|
CLK2
|
100
|
4
|
CSK
|
98
|
13
|
DAPK1
|
97
|
13
|
DYRK1A
|
100
|
2
|
DYRK2
|
96
|
1
|
DYRK3
|
87
|
4
|
EF2K
|
96
|
9
|
EIF2AK3
|
104
|
11
|
EPH-A2
|
89
|
3
|
EPH-A4
|
97
|
3
|
EPH-B1
|
96
|
5
|
EPH-B2
|
97
|
4
|
EPH-B3
|
101
|
6
|
EPH-B4
|
95
|
1
|
ERK1
|
78
|
3
|
ERK2
|
90
|
5
|
ERK8
|
84
|
9
|
FGF-R1
|
98
|
7
|
GCK
|
81
|
4
|
GSK3 beta
|
96
|
7
|
HER4
|
97
|
2
|
HIPK1
|
97
|
7
|
HIPK2
|
91
|
4
|
HIPK3
|
96
|
3
|
IGF-1R
|
92
|
1
|
IKK beta
|
33
|
0
|
IKK epsilon
|
75
|
3
|
IR
|
97
|
4
|
IRAK1
|
80
|
1
|
IRAK4
|
98
|
7
|
IRR
|
84
|
1
|
JAK2
|
83
|
0
|
JNK1
|
78
|
15
|
JNK2
|
95
|
1
|
JNK3
|
118
|
7
|
Lck
|
108
|
10
|
LKB1
|
92
|
4
|
MAPKAP-K2
|
109
|
9
|
MAPKAP-K3
|
85
|
6
|
MARK1
|
84
|
3
|
MARK2
|
91
|
11
|
MARK3
|
94
|
7
|
MARK4
|
81
|
11
|
MEKK1
|
115
|
1
|
MELK
|
106
|
5
|
MINK1
|
85
|
12
|
MKK1
|
110
|
11
|
MKK2
|
93
|
6
|
MKK6
|
87
|
8
|
MLK1
|
95
|
1
|
MLK3
|
96
|
1
|
MNK1
|
88
|
6
|
MNK2
|
97
|
4
|
MPSK1
|
94
|
0
|
MSK1
|
115
|
14
|
MST2
|
84
|
11
|
MST4
|
92
|
11
|
NEK2a
|
98
|
10
|
NEK6
|
104
|
1
|
NUAK1
|
81
|
10
|
OSR1
|
98
|
9
|
p38 alpha MAPK
|
91
|
6
|
p38 beta MAPK
|
96
|
13
|
p38 delta MAPK
|
92
|
4
|
p38 gamma MAPK
|
92
|
5
|
PAK2
|
96
|
4
|
PAK4
|
93
|
10
|
PAK5
|
92
|
7
|
PAK6
|
93
|
3
|
PDK1
|
85
|
12
|
PHK
|
101
|
3
|
PIM1
|
96
|
11
|
PIM2
|
87
|
4
|
PIM3
|
85
|
3
|
PKA
|
84
|
7
|
PKB alpha
|
89
|
5
|
PKB beta
|
100
|
1
|
PKC alpha
|
94
|
3
|
PKC gamma
|
101
|
8
|
PKC zeta
|
87
|
5
|
PKD1
|
90
|
1
|
PLK1
|
94
|
4
|
PRAK
|
101
|
6
|
PRK2
|
98
|
3
|
RIPK2
|
96
|
7
|
ROCK 2
|
100
|
4
|
RSK1
|
112
|
6
|
RSK2
|
104
|
8
|
S6K1
|
85
|
5
|
SGK1
|
89
|
5
|
SmMLCK
|
88
|
5
|
Src
|
81
|
4
|
SRPK1
|
95
|
13
|
STK33
|
86
|
0
|
SYK
|
86
|
11
|
TAK1
|
100
|
1
|
TAO1
|
89
|
4
|
TBK1
|
100
|
21
|
TIE2
|
87
|
1
|
TLK1
|
94
|
10
|
TrkA
|
109
|
2
|
TTK
|
96
|
11
|
VEGFR1
|
81
|
3
|
YES1
|
108
|
6
|
ZAP70
|
102
|
8
|
Screen Conc:
1.00µM
Kinase |
% Activity Remaining |
Standard Deviation |
ABL
|
102
|
10
|
AMPK
|
94
|
8
|
ASK1
|
92
|
4
|
Aurora A
|
112
|
6
|
Aurora B
|
96
|
4
|
BRK
|
103
|
2
|
BRSK1
|
105
|
7
|
BRSK2
|
110
|
12
|
BTK
|
108
|
1
|
CAMK1
|
98
|
6
|
CAMKK beta
|
89
|
13
|
CDK2-Cyclin A
|
88
|
6
|
CHK1
|
101
|
2
|
CHK2
|
104
|
2
|
CK1 delta
|
80
|
2
|
CK2
|
84
|
14
|
CLK2
|
102
|
1
|
CSK
|
112
|
6
|
DAPK1
|
86
|
9
|
DYRK1A
|
100
|
6
|
DYRK2
|
98
|
11
|
DYRK3
|
82
|
1
|
EF2K
|
105
|
7
|
EIF2AK3
|
109
|
4
|
EPH-A2
|
106
|
6
|
EPH-A4
|
110
|
5
|
EPH-B1
|
114
|
8
|
EPH-B2
|
102
|
7
|
EPH-B3
|
117
|
8
|
EPH-B4
|
100
|
10
|
ERK1
|
108
|
8
|
ERK2
|
105
|
2
|
ERK8
|
102
|
7
|
FGF-R1
|
82
|
2
|
GCK
|
87
|
3
|
GSK3 beta
|
108
|
5
|
HER4
|
95
|
8
|
HIPK1
|
106
|
10
|
HIPK2
|
100
|
13
|
HIPK3
|
96
|
7
|
IGF-1R
|
62
|
7
|
IKK beta
|
16
|
2
|
IKK epsilon
|
98
|
14
|
IR
|
80
|
1
|
IRAK1
|
84
|
9
|
IRAK4
|
96
|
6
|
IRR
|
57
|
1
|
JAK2
|
93
|
13
|
JNK1
|
85
|
5
|
JNK2
|
109
|
2
|
JNK3
|
94
|
9
|
Lck
|
104
|
2
|
LKB1
|
106
|
5
|
MAPKAP-K2
|
101
|
18
|
MAPKAP-K3
|
92
|
9
|
MARK1
|
94
|
15
|
MARK2
|
85
|
2
|
MARK3
|
96
|
8
|
MARK4
|
108
|
12
|
MEKK1
|
126
|
4
|
MELK
|
104
|
0
|
MINK1
|
91
|
0
|
MKK1
|
120
|
8
|
MKK2
|
97
|
13
|
MKK6
|
104
|
2
|
MLK1
|
98
|
8
|
MLK3
|
114
|
12
|
MNK1
|
76
|
8
|
MNK2
|
109
|
3
|
MPSK1
|
113
|
6
|
MSK1
|
102
|
4
|
MST2
|
90
|
1
|
MST4
|
99
|
3
|
NEK2a
|
97
|
3
|
NEK6
|
130
|
0
|
NUAK1
|
93
|
14
|
OSR1
|
98
|
4
|
p38 alpha MAPK
|
83
|
0
|
p38 beta MAPK
|
93
|
4
|
p38 delta MAPK
|
105
|
2
|
p38 gamma MAPK
|
85
|
0
|
PAK2
|
105
|
5
|
PAK4
|
90
|
6
|
PAK5
|
102
|
8
|
PAK6
|
113
|
2
|
PDK1
|
81
|
4
|
PHK
|
105
|
4
|
PIM1
|
82
|
4
|
PIM2
|
96
|
2
|
PIM3
|
74
|
9
|
PKA
|
88
|
3
|
PKB alpha
|
85
|
14
|
PKB beta
|
120
|
10
|
PKC alpha
|
87
|
2
|
PKC gamma
|
130
|
7
|
PKC zeta
|
87
|
5
|
PKD1
|
123
|
2
|
PLK1
|
103
|
2
|
PRAK
|
75
|
16
|
PRK2
|
87
|
5
|
RIPK2
|
76
|
2
|
ROCK 2
|
86
|
10
|
RSK1
|
113
|
12
|
RSK2
|
113
|
10
|
S6K1
|
99
|
5
|
SGK1
|
101
|
10
|
SmMLCK
|
86
|
6
|
Src
|
106
|
11
|
SRPK1
|
102
|
1
|
STK33
|
98
|
6
|
SYK
|
108
|
3
|
TAK1
|
109
|
8
|
TAO1
|
124
|
13
|
TBK1
|
103
|
15
|
TIE2
|
108
|
2
|
TLK1
|
91
|
13
|
TrkA
|
115
|
11
|
TTK
|
99
|
7
|
VEGFR1
|
88
|
0
|
YES1
|
89
|
12
|
ZAP70
|
103
|
1
|