Inhibitor |
Febuxostat (TMX-67, Adenuric, Uloric)
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
96
|
5
|
|
AMPK
|
92
|
3
|
|
ASK1
|
152
|
89
|
|
Aurora A
|
104
|
20
|
|
Aurora B
|
95
|
7
|
|
BRK
|
99
|
19
|
|
BRSK1
|
94
|
8
|
|
BRSK2
|
100
|
6
|
|
BTK
|
103
|
6
|
|
CAMK1
|
98
|
18
|
|
CAMKK beta
|
92
|
11
|
|
CDK2-Cyclin A
|
106
|
9
|
|
CHK1
|
85
|
12
|
|
CHK2
|
101
|
17
|
|
CK1 delta
|
79
|
1
|
|
CK2
|
87
|
3
|
|
CLK2
|
81
|
9
|
|
CSK
|
148
|
9
|
|
DAPK1
|
85
|
13
|
|
DYRK1A
|
102
|
10
|
|
DYRK2
|
95
|
6
|
|
DYRK3
|
84
|
13
|
|
EF2K
|
102
|
7
|
|
EIF2AK3
|
94
|
1
|
|
EPH-A2
|
104
|
9
|
|
EPH-A4
|
131
|
52
|
|
EPH-B1
|
118
|
3
|
|
EPH-B2
|
122
|
9
|
|
EPH-B3
|
61
|
20
|
|
EPH-B4
|
93
|
8
|
|
ERK1
|
105
|
51
|
|
ERK2
|
105
|
15
|
|
ERK8
|
88
|
20
|
|
FGF-R1
|
103
|
20
|
|
GCK
|
85
|
2
|
|
GSK3 beta
|
90
|
2
|
|
HER4
|
102
|
4
|
|
HIPK1
|
90
|
4
|
|
HIPK2
|
100
|
5
|
|
HIPK3
|
108
|
18
|
|
IGF-1R
|
93
|
8
|
|
IKK beta
|
100
|
13
|
|
IKK epsilon
|
138
|
0
|
|
IR
|
102
|
11
|
|
IRAK1
|
106
|
2
|
|
IRAK4
|
90
|
7
|
|
IRR
|
66
|
3
|
|
JAK2
|
92
|
21
|
|
JNK1
|
95
|
6
|
|
JNK2
|
90
|
1
|
|
JNK3
|
99
|
6
|
|
Lck
|
110
|
9
|
|
LKB1
|
86
|
5
|
|
MAPKAP-K2
|
52
|
23
|
|
MAPKAP-K3
|
102
|
10
|
|
MARK1
|
96
|
3
|
|
MARK2
|
60
|
7
|
|
MARK3
|
91
|
5
|
|
MARK4
|
96
|
15
|
|
MEKK1
|
106
|
12
|
|
MELK
|
84
|
1
|
|
MINK1
|
122
|
27
|
|
MKK1
|
85
|
17
|
|
MKK2
|
77
|
17
|
|
MKK6
|
85
|
14
|
|
MLK1
|
69
|
2
|
|
MLK3
|
80
|
8
|
|
MNK1
|
106
|
6
|
|
MNK2
|
105
|
14
|
|
MPSK1
|
46
|
1
|
|
MSK1
|
94
|
9
|
|
MST2
|
73
|
4
|
|
MST4
|
94
|
12
|
|
NEK2a
|
89
|
16
|
|
NEK6
|
100
|
3
|
|
NUAK1
|
95
|
4
|
|
OSR1
|
96
|
6
|
|
p38 alpha MAPK
|
105
|
1
|
|
p38 beta MAPK
|
84
|
4
|
|
p38 delta MAPK
|
103
|
11
|
|
p38 gamma MAPK
|
84
|
1
|
|
PAK2
|
95
|
7
|
|
PAK4
|
85
|
1
|
|
PAK5
|
101
|
3
|
|
PAK6
|
97
|
16
|
|
PDK1
|
103
|
10
|
|
PHK
|
85
|
8
|
|
PIM1
|
83
|
4
|
|
PIM2
|
110
|
10
|
|
PIM3
|
66
|
4
|
|
PKA
|
99
|
2
|
|
PKB alpha
|
97
|
17
|
|
PKB beta
|
109
|
6
|
|
PKC alpha
|
94
|
4
|
|
PKC gamma
|
81
|
9
|
|
PKC zeta
|
93
|
3
|
|
PKD1
|
95
|
6
|
|
PLK1
|
94
|
3
|
|
PRAK
|
87
|
1
|
|
PRK2
|
120
|
6
|
|
RIPK2
|
97
|
4
|
|
ROCK 2
|
96
|
15
|
|
RSK1
|
92
|
2
|
|
RSK2
|
99
|
10
|
|
S6K1
|
99
|
3
|
|
SGK1
|
99
|
8
|
|
SmMLCK
|
101
|
2
|
|
Src
|
97
|
11
|
|
SRPK1
|
99
|
0
|
|
STK33
|
101
|
0
|
|
SYK
|
158
|
9
|
|
TAK1
|
88
|
10
|
|
TAO1
|
105
|
6
|
|
TBK1
|
127
|
15
|
|
TIE2
|
78
|
13
|
|
TLK1
|
86
|
1
|
|
TrkA
|
88
|
2
|
|
TTK
|
89
|
4
|
|
VEGFR1
|
83
|
10
|
|
YES1
|
117
|
7
|
|
ZAP70
|
104
|
10
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
89
|
2
|
|
AMPK
|
83
|
4
|
|
ASK1
|
127
|
16
|
|
Aurora A
|
94
|
17
|
|
Aurora B
|
96
|
7
|
|
BRK
|
100
|
24
|
|
BRSK1
|
91
|
7
|
|
BRSK2
|
86
|
7
|
|
BTK
|
101
|
0
|
|
CAMK1
|
93
|
13
|
|
CAMKK beta
|
73
|
5
|
|
CDK2-Cyclin A
|
106
|
3
|
|
CHK1
|
86
|
2
|
|
CHK2
|
60
|
9
|
|
CK1 delta
|
93
|
13
|
|
CK2
|
71
|
0
|
|
CLK2
|
77
|
5
|
|
CSK
|
119
|
13
|
|
DAPK1
|
60
|
3
|
|
DYRK1A
|
85
|
0
|
|
DYRK2
|
83
|
6
|
|
DYRK3
|
65
|
12
|
|
EF2K
|
95
|
2
|
|
EIF2AK3
|
88
|
7
|
|
EPH-A2
|
89
|
3
|
|
EPH-A4
|
107
|
13
|
|
EPH-B1
|
103
|
1
|
|
EPH-B2
|
102
|
2
|
|
EPH-B3
|
83
|
0
|
|
EPH-B4
|
79
|
2
|
|
ERK1
|
95
|
16
|
|
ERK2
|
101
|
23
|
|
ERK8
|
80
|
26
|
|
FGF-R1
|
103
|
9
|
|
GCK
|
86
|
11
|
|
GSK3 beta
|
74
|
11
|
|
HER4
|
103
|
13
|
|
HIPK1
|
95
|
12
|
|
HIPK2
|
98
|
4
|
|
HIPK3
|
119
|
15
|
|
IGF-1R
|
89
|
6
|
|
IKK beta
|
99
|
1
|
|
IKK epsilon
|
100
|
15
|
|
IR
|
96
|
1
|
|
IRAK1
|
102
|
0
|
|
IRAK4
|
98
|
12
|
|
IRR
|
68
|
2
|
|
JAK2
|
83
|
11
|
|
JNK1
|
103
|
0
|
|
JNK2
|
86
|
18
|
|
JNK3
|
92
|
11
|
|
Lck
|
102
|
11
|
|
LKB1
|
85
|
8
|
|
MAPKAP-K2
|
44
|
17
|
|
MAPKAP-K3
|
95
|
0
|
|
MARK1
|
104
|
2
|
|
MARK2
|
59
|
11
|
|
MARK3
|
87
|
3
|
|
MARK4
|
85
|
3
|
|
MEKK1
|
96
|
14
|
|
MELK
|
87
|
7
|
|
MINK1
|
104
|
2
|
|
MKK1
|
77
|
21
|
|
MKK2
|
73
|
5
|
|
MKK6
|
81
|
13
|
|
MLK1
|
47
|
14
|
|
MLK3
|
47
|
5
|
|
MNK1
|
95
|
8
|
|
MNK2
|
91
|
16
|
|
MPSK1
|
47
|
3
|
|
MSK1
|
102
|
2
|
|
MST2
|
75
|
9
|
|
MST4
|
90
|
16
|
|
NEK2a
|
98
|
11
|
|
NEK6
|
99
|
8
|
|
NUAK1
|
73
|
8
|
|
OSR1
|
80
|
5
|
|
p38 alpha MAPK
|
104
|
33
|
|
p38 beta MAPK
|
91
|
5
|
|
p38 delta MAPK
|
97
|
11
|
|
p38 gamma MAPK
|
96
|
12
|
|
PAK2
|
90
|
3
|
|
PAK4
|
67
|
15
|
|
PAK5
|
88
|
2
|
|
PAK6
|
107
|
1
|
|
PDK1
|
76
|
21
|
|
PHK
|
83
|
6
|
|
PIM1
|
66
|
17
|
|
PIM2
|
88
|
2
|
|
PIM3
|
19
|
5
|
|
PKA
|
91
|
4
|
|
PKB alpha
|
95
|
7
|
|
PKB beta
|
108
|
2
|
|
PKC alpha
|
92
|
16
|
|
PKC gamma
|
85
|
13
|
|
PKC zeta
|
96
|
8
|
|
PKD1
|
94
|
10
|
|
PLK1
|
91
|
3
|
|
PRAK
|
82
|
9
|
|
PRK2
|
139
|
45
|
|
RIPK2
|
88
|
15
|
|
ROCK 2
|
80
|
17
|
|
RSK1
|
84
|
14
|
|
RSK2
|
92
|
1
|
|
S6K1
|
99
|
14
|
|
SGK1
|
98
|
10
|
|
SmMLCK
|
79
|
8
|
|
Src
|
78
|
13
|
|
SRPK1
|
89
|
12
|
|
STK33
|
89
|
0
|
|
SYK
|
117
|
15
|
|
TAK1
|
81
|
2
|
|
TAO1
|
101
|
7
|
|
TBK1
|
128
|
27
|
|
TIE2
|
67
|
7
|
|
TLK1
|
94
|
14
|
|
TrkA
|
80
|
20
|
|
TTK
|
87
|
11
|
|
VEGFR1
|
71
|
7
|
|
YES1
|
90
|
20
|
|
ZAP70
|
96
|
31
|
