Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
BIO (6-Bromoindirubin-3'-oxime) | C16H10BrN3O2 | 356.20 | 667463-62-9 | 5287844 | GSK3 | Tseng A.S. (2006) Chem. Biol. 13 957 | Polychronopoulos P. (2004) J. Med. Chem. 47 935 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 91 | 21 |
Aurora B | 94 | 11 |
BRSK2 | 112 | 5 |
BTK | 93 | 12 |
CAMK1 | 97 | 17 |
CAMKK beta | 93 | 0 |
CDK2-Cyclin A | 88 | 7 |
CHK1 | 82 | 18 |
CHK2 | 77 | 19 |
CK1 delta | 87 | 10 |
CK2 | 96 | 3 |
CSK | 109 | 9 |
DYRK1A | 102 | 10 |
DYRK2 | 93 | 16 |
DYRK3 | 108 | 4 |
EF2K | 108 | 9 |
EPH-A2 | 94 | 3 |
EPH-B3 | 89 | 10 |
ERK1 | 88 | 13 |
ERK2 | 93 | 12 |
ERK8 | 95 | 10 |
FGF-R1 | 95 | 5 |
GSK3 beta | 85 | 9 |
HIPK2 | 101 | 2 |
IGF-1R | 106 | 8 |
IKK beta | 106 | 11 |
IKK epsilon | 101 | 0 |
IR | 107 | 0 |
IRR | 93 | 8 |
JNK1 | 98 | 6 |
JNK2 | 94 | 5 |
Lck | 89 | 10 |
MAPKAP-K2 | 103 | 6 |
MARK3 | 97 | 4 |
MELK | 86 | 12 |
MKK1 | 96 | 1 |
MNK1 | 118 | 4 |
MNK2 | 86 | 5 |
MSK1 | 97 | 6 |
MST2 | 87 | 8 |
MST4 | 98 | 4 |
NEK2a | 96 | 6 |
NEK6 | 88 | 12 |
p38 alpha MAPK | 103 | 22 |
p38 beta MAPK | 87 | 7 |
p38 delta MAPK | 108 | 10 |
p38 gamma MAPK | 95 | 1 |
PAK4 | 95 | 18 |
PAK5 | 107 | 0 |
PAK6 | 102 | 16 |
PDK1 | 100 | 6 |
PHK | 101 | 18 |
PIM1 | 100 | 10 |
PIM2 | 111 | 5 |
PIM3 | 96 | 8 |
PKA | 102 | 1 |
PKB alpha | 89 | 10 |
PKB beta | 100 | 3 |
PKC alpha | 113 | 1 |
PKC zeta | 107 | 12 |
PKD1 | 98 | 6 |
PLK1 | 91 | 6 |
PRAK | 97 | 3 |
PRK2 | 103 | 15 |
ROCK 2 | 100 | 5 |
RSK1 | 107 | 3 |
RSK2 | 93 | 4 |
S6K1 | 87 | 10 |
SGK1 | 88 | 8 |
SmMLCK | 84 | 19 |
Src | 73 | 13 |
SRPK1 | 87 | 8 |
SYK | 99 | 2 |
TBK1 | 94 | 13 |
VEGFR1 | 95 | 6 |
YES1 | 76 | 6 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 40 | 5 |
ASK1 | 94 | 2 |
Aurora A | 50 | 3 |
Aurora B | 51 | 11 |
BRSK1 | 14 | 3 |
BRSK2 | 48 | 1 |
BTK | 29 | 4 |
CAMK1 | 26 | 7 |
CAMKK beta | 83 | 2 |
CDK2-Cyclin A | 29 | 1 |
CHK1 | 78 | 5 |
CHK2 | 67 | 3 |
CK1 delta | 111 | 4 |
CK2 | 92 | 1 |
CLK2 | 81 | 1 |
CSK | 87 | 8 |
DAPK1 | 60 | 0 |
DYRK1A | 91 | 5 |
DYRK2 | 85 | 8 |
DYRK3 | 96 | 2 |
EF2K | 85 | 2 |
EPH-A2 | 75 | 14 |
EPH-A4 | 88 | 5 |
EPH-B1 | 102 | 1 |
EPH-B2 | 85 | 6 |
EPH-B3 | 93 | 5 |
EPH-B4 | 111 | 3 |
ERK1 | 104 | 3 |
ERK2 | 112 | 12 |
ERK8 | 76 | 2 |
FGF-R1 | 43 | 5 |
GCK | 52 | 0 |
GSK3 beta |
7
|
0 |
HER4 | 100 | 1 |
HIPK1 | 98 | 3 |
HIPK2 | 58 | 2 |
HIPK3 | 108 | 14 |
IGF-1R | 63 | 5 |
IKK beta | 106 | 5 |
IKK epsilon | 80 | 12 |
IR | 129 | 12 |
IRAK4 | 74 | 8 |
IRR | 88 | 2 |
JAK2 | 56 | 2 |
JNK1 | 110 | 2 |
JNK2 | 105 | 9 |
JNK3 | 88 | 6 |
Lck | 38 | 2 |
LKB1 | 75 | 1 |
MAPKAP-K2 | 91 | 2 |
MAPKAP-K3 | 91 | 11 |
MARK1 | 100 | 8 |
MARK2 | 94 | 5 |
MARK3 | 72 | 5 |
MARK4 | 81 | 4 |
MEKK1 | 78 | 7 |
MELK | 71 | 1 |
MINK1 | 67 | 1 |
MKK1 | 100 | 13 |
MKK2 | 104 | 9 |
MKK6 | 118 | 12 |
MLK1 | 48 | 2 |
MLK3 | 14 | 3 |
MNK1 | 96 | 1 |
MNK2 | 76 | 2 |
MSK1 | 94 | 8 |
MST2 | 19 | 1 |
MST4 | 112 | 1 |
NEK2a | 102 | 3 |
NEK6 | 102 | 8 |
NUAK1 | 51 | 8 |
p38 alpha MAPK | 105 | 2 |
p38 beta MAPK | 77 | 6 |
p38 delta MAPK | 106 | 4 |
p38 gamma MAPK | 94 | 5 |
PAK2 | 77 | 1 |
PAK4 | 78 | 7 |
PAK5 | 92 | 2 |
PAK6 | 100 | 6 |
PDK1 | 84 | 6 |
PHK | 51 | 3 |
PIM1 | 99 | 7 |
PIM2 | 88 | 8 |
PIM3 | 73 | 3 |
PKA | 109 | 4 |
PKB alpha | 104 | 2 |
PKB beta | 86 | 1 |
PKC alpha | 97 | 5 |
PKC zeta | 96 | 1 |
PKD1 | 112 | 15 |
PLK1 | 95 | 6 |
PRAK | 103 | 2 |
PRK2 | 103 | 2 |
RIPK2 | 111 | 6 |
ROCK 2 | 105 | 8 |
RSK1 | 82 | 2 |
RSK2 | 114 | 6 |
S6K1 | 93 | 6 |
SGK1 | 77 | 10 |
SmMLCK | 71 | 6 |
Src | 16 | 5 |
SRPK1 | 107 | 10 |
SYK | 75 | 9 |
TAK1 | 71 | 2 |
TAO1 | 109 | 7 |
TBK1 | 54 | 0 |
TrkA | 13 | 0 |
TTK | 86 | 6 |
VEGFR1 | 27 | 1 |
YES1 | 41 | 4 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK |
6
|
0 |
BRSK2 | 13 | 4 |
BTK |
2
|
0 |
CAMK1 |
10
|
0 |
CAMKK beta |
9
|
0 |
CDK2-Cyclin A |
4
|
0 |
CHK1 | 12 | 3 |
CHK2 |
4
|
2 |
CK1 delta | 57 | 3 |
CK2 | 76 | 0 |
CSK | 20 | 0 |
DYRK1A | 22 | 0 |
DYRK2 | 44 | 2 |
DYRK3 | 58 | 0 |
EF2K | 81 | 2 |
EPH-A2 | 11 | 0 |
EPH-B3 | 35 | 13 |
ERK1 | 67 | 4 |
ERK2 | 88 | 2 |
ERK8 |
2
|
0 |
FGF-R1 |
3
|
0 |
GSK3 beta |
8
|
8 |
HIPK2 |
3
|
0 |
IGF-1R | 11 | 2 |
IKK beta | 86 | 6 |
IKK epsilon |
9
|
0 |
IR | 38 | 3 |
IRR | 18 | 3 |
JNK1 | 57 | 4 |
JNK2 | 53 | 1 |
Lck |
3
|
1 |
MAPKAP-K2 | 68 | 7 |
MARK3 | 17 | 4 |
MELK |
4
|
2 |
MKK1 | 35 | 4 |
MNK1 | 55 | 3 |
MNK2 | 50 | 0 |
MSK1 | 27 | 2 |
MST2 |
2
|
0 |
MST4 | 11 | 0 |
NEK2a | 91 | 16 |
NEK6 | 73 | 5 |
p38 alpha MAPK | 70 | 19 |
p38 beta MAPK | 41 | 0 |
p38 delta MAPK | 70 | 0 |
p38 gamma MAPK | 49 | 2 |
PAK4 |
9
|
4 |
PAK5 | 13 | 0 |
PAK6 | 22 | 0 |
PDK1 |
1
|
0 |
PHK |
3
|
0 |
PIM1 | 35 | 2 |
PIM2 | 26 | 9 |
PIM3 | 12 | 3 |
PKA | 81 | 4 |
PKB alpha | 72 | 3 |
PKB beta | 51 | 6 |
PKC alpha | 37 | 0 |
PKC zeta | 69 | 4 |
PKD1 | 66 | 3 |
PLK1 | 51 | 8 |
PRAK | 45 | 5 |
PRK2 | 45 | 7 |
ROCK 2 | 24 | 1 |
RSK1 |
7
|
1 |
RSK2 | 35 | 3 |
S6K1 | 21 | 1 |
SGK1 |
9
|
0 |
SmMLCK | 14 | 3 |
Src |
5
|
1 |
SRPK1 | 68 | 5 |
SYK | 17 | 20 |
TBK1 |
7
|
1 |
VEGFR1 |
5
|
2 |
YES1 |
4
|
0 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK |
6
|
0 |
BRSK2 | 16 | 0 |
BTK |
2
|
0 |
CAMK1 |
7
|
0 |
CAMKK beta |
6
|
1 |
CDK2-Cyclin A |
5
|
0 |
CHK1 |
9
|
1 |
CHK2 |
4
|
0 |
CK1 delta | 34 | 2 |
CK2 | 59 | 4 |
CSK | 19 | 6 |
DYRK1A | 14 | 1 |
DYRK2 | 31 | 4 |
DYRK3 | 48 | 1 |
EF2K | 82 | 1 |
EPH-A2 | 11 | 1 |
EPH-B3 | 25 | 8 |
ERK1 | 41 | 2 |
ERK2 | 83 | 4 |
ERK8 |
2
|
0 |
FGF-R1 |
2
|
0 |
GSK3 beta |
8
|
6 |
HIPK2 |
6
|
3 |
IGF-1R |
6
|
2 |
IKK beta | 68 | 6 |
IKK epsilon | 11 | 8 |
IR | 20 | 3 |
IRR | 17 | 3 |
JNK1 | 48 | 3 |
JNK2 | 46 | 2 |
Lck |
5
|
2 |
MAPKAP-K2 | 33 | 27 |
MARK3 |
10
|
1 |
MELK |
4
|
1 |
MKK1 | 34 | 5 |
MNK1 | 56 | 1 |
MNK2 | 58 | 6 |
MSK1 |
7
|
1 |
MST2 |
8
|
5 |
MST4 | 11 | 0 |
NEK2a | 81 | 5 |
NEK6 | 13 | 2 |
p38 alpha MAPK | 54 | 10 |
p38 beta MAPK | 31 | 2 |
p38 delta MAPK | 53 | 11 |
p38 gamma MAPK | 43 | 1 |
PAK4 |
7
|
2 |
PAK5 |
9
|
1 |
PAK6 | 22 | 0 |
PDK1 |
4
|
0 |
PHK |
1
|
0 |
PIM1 | 22 | 1 |
PIM2 | 14 | 4 |
PIM3 |
5
|
2 |
PKA | 28 | 2 |
PKB alpha | 67 | 4 |
PKB beta | 24 | 12 |
PKC alpha | 25 | 0 |
PKC zeta | 47 | 5 |
PKD1 | 52 | 8 |
PLK1 | 36 | 0 |
PRAK | 23 | 14 |
PRK2 | 46 | 5 |
ROCK 2 | 14 | 0 |
RSK1 |
9
|
5 |
RSK2 | 36 | 0 |
S6K1 |
3
|
0 |
SGK1 |
0
|
0 |
SmMLCK | 14 | 2 |
Src |
5
|
0 |
SRPK1 | 57 | 0 |
SYK |
2
|
0 |
TBK1 |
6
|
0 |
VEGFR1 |
2
|
1 |
YES1 |
4
|
0 |