Inhibitor | AX 20017  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
VEGFR1	9	0
GCK	17	2
Aurora A	22	3
IRAK4	28	2
TrkA	30	3
NUAK1	30	2
MLK1	32	9
CHK2	35	4
RIPK2	36	1
MINK1	37	7
MLK3	37	1
GSK3 beta	42	2
MELK	44	5
FGF-R1	46	14
PAK4	46	4
DYRK1A	48	2
CAMKK beta	48	4
CDK2-Cyclin A	48	1
SmMLCK	49	4
CLK2	49	13
IRR	52	4
HIPK2	52	2
EPH-A2	52	6
TAK1	53	8
MST2	53	3
EPH-A4	53	6
PAK5	54	10
EPH-B4	55	3
MST4	57	3
JAK2	60	5
EPH-B2	62	7
PHK	62	1
Aurora B	62	16
PRAK	62	9
ERK8	67	5
MARK1	67	4
PIM3	68	9
BTK	68	1
TAO1	69	11
MARK3	69	5
MARK4	69	12
CAMK1	70	5
BRSK2	73	8
STK33	74	10
MKK2	74	10
TIE2	75	18
EPH-B1	76	39
Lck	77	6
MNK1	77	3
IGF-1R	79	1
YES1	79	13
TTK	80	13
ZAP70	80	8
PAK6	80	14
CK1 delta	81	10
LKB1	81	11
ABL	82	11
JNK3	84	1
CHK1	84	1
PKC alpha	86	9
DAPK1	86	12
AMPK	86	12
DYRK2	86	2
Src	87	2
HIPK1	87	7
PIM1	87	2
CSK	88	5
MKK1	88	5
RSK2	89	1
ERK2	89	14
BRSK1	90	1
EF2K	90	12
PKD1	90	9
MAPKAP-K2	91	22
ROCK 2	91	3
MPSK1	92	3
NEK2a	92	2
PIM2	92	0
SRPK1	93	6
MAPKAP-K3	93	6
NEK6	93	3
IKK beta	93	5
p38 gamma MAPK	94	12
RSK1	95	1
BRK	95	7
PAK2	96	14
PKB beta	96	0
ASK1	96	4
JNK2	96	2
IR	97	0
p38 delta MAPK	97	9
PRK2	97	13
HER4	98	2
p38 beta MAPK	98	1
S6K1	98	6
MKK6	99	1
PLK1	100	4
p38 alpha MAPK	101	16
HIPK3	102	10
PDK1	102	11
PKB alpha	102	10
PKA	102	15
JNK1	102	10
PKC zeta	104	11
CK2	106	11
SYK	106	9
SGK1	107	5
TBK1	107	2
MSK1	108	11
EPH-B3	109	6
DYRK3	109	11
IKK epsilon	109	11
PKC gamma	110	5
MNK2	115	13
MARK2	124	73
ERK1	125	16
MEKK1	132	51

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
VEGFR1	45	3
IRAK4	68	5
GCK	69	2
MELK	71	16
MLK1	72	11
CHK2	74	7
NUAK1	75	0
Aurora B	79	4
MINK1	80	7
PAK6	83	8
DYRK1A	85	4
PKD1	86	11
IGF-1R	86	1
RIPK2	86	16
EPH-A2	87	9
STK33	87	4
Aurora A	87	6
TAO1	87	0
CDK2-Cyclin A	89	3
MLK3	89	1
HIPK3	89	6
CLK2	89	5
MST2	90	16
MARK3	90	3
GSK3 beta	90	8
BTK	90	2
TrkA	90	2
LKB1	91	7
MKK1	92	2
YES1	92	7
TAK1	92	17
PAK2	92	1
PAK4	93	2
p38 gamma MAPK	93	5
MARK1	93	9
MKK2	93	3
ABL	93	1
PKC alpha	93	0
ZAP70	94	8
CK2	94	22
HIPK2	94	9
JNK3	94	3
CHK1	95	3
ROCK 2	95	4
CK1 delta	96	10
PIM1	96	4
PRAK	96	4
CSK	96	2
SmMLCK	96	5
MARK2	97	5
MNK1	97	9
BRSK1	97	3
SRPK1	97	7
EF2K	97	9
JNK1	97	3
IRR	97	5
PKC gamma	98	7
MAPKAP-K2	98	15
PIM2	98	1
Lck	98	13
PLK1	98	9
CAMK1	98	3
p38 beta MAPK	99	10
TBK1	99	15
ERK2	99	1
BRSK2	99	6
NEK2a	99	1
TTK	100	17
TIE2	100	22
PAK5	100	10
MST4	100	1
MAPKAP-K3	100	2
PKB beta	100	2
S6K1	100	3
HIPK1	100	16
PKA	100	1
p38 alpha MAPK	100	10
IKK beta	100	4
RSK1	101	9
EPH-B4	101	1
IR	101	8
DAPK1	102	2
Src	102	0
SYK	102	7
AMPK	103	11
PKC zeta	104	0
EPH-B2	104	12
JAK2	104	6
MARK4	105	0
FGF-R1	105	6
ERK8	106	1
MNK2	106	4
HER4	106	4
CAMKK beta	106	7
ASK1	106	8
JNK2	106	5
PRK2	106	0
RSK2	107	16
MPSK1	107	3
ERK1	107	15
NEK6	107	14
MSK1	108	1
PHK	108	13
DYRK2	109	2
MKK6	109	2
SGK1	109	5
PDK1	111	14
PIM3	111	9
DYRK3	111	9
BRK	114	1
EPH-A4	114	13
EPH-B3	115	5
PKB alpha	115	7
p38 delta MAPK	116	4
EPH-B1	117	14
MEKK1	124	42
IKK epsilon	211	147