Inhibitor | MK-2206  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CAMK1	35	5
RIPK2	38	4
CHK2	39	0
CHK1	45	6
DAPK1	48	6
TAK1	49	4
PIM3	51	8
VEGFR1	53	1
IGF-1R	55	3
DYRK1A	57	5
MNK1	58	6
IRR	61	0
RSK1	62	5
SGK1	63	4
PAK4	66	6
MLK1	66	5
CLK2	67	8
PIM1	68	0
PHK	68	5
YES1	68	6
PKB beta	68	3
MINK1	69	3
FGF-R1	70	3
GSK3 beta	72	11
SmMLCK	72	3
EPH-B2	74	8
CDK2-Cyclin A	75	1
ERK2	75	10
PAK5	75	4
PKB alpha	75	3
p38 beta MAPK	76	0
MSK1	76	9
Aurora B	78	4
TTK	80	8
Lck	80	3
MELK	80	5
HIPK2	80	7
DYRK3	81	0
MLK3	81	2
RSK2	81	0
MEKK1	83	2
IR	83	12
AMPK	83	10
S6K1	84	0
JNK3	84	2
CAMKK beta	84	5
CK2	84	1
TAO1	85	2
CSK	85	4
GCK	85	4
LKB1	86	3
EPH-B4	86	6
DYRK2	87	0
EPH-A2	87	14
JNK1	87	6
BRSK1	87	8
NEK2a	87	4
TrkA	87	5
MAPKAP-K2	88	2
IKK beta	89	2
TBK1	89	13
PKA	90	7
NEK6	90	1
ASK1	90	4
MKK1	90	5
MKK2	90	7
MARK3	91	5
ROCK 2	91	12
PAK6	91	2
CK1 delta	91	2
IKK epsilon	91	6
MARK4	92	3
PRK2	92	0
MNK2	92	10
ERK1	93	4
Aurora A	93	13
ERK8	93	1
PLK1	94	4
BRSK2	94	5
MST2	94	12
MAPKAP-K3	94	5
MARK2	94	8
JAK2	94	0
NUAK1	95	6
SYK	96	14
HER4	97	7
PIM2	97	5
JNK2	97	6
EPH-A4	97	5
PKC zeta	97	4
HIPK1	97	13
PKC alpha	98	12
MARK1	98	4
BTK	99	4
IRAK4	99	5
EPH-B1	100	12
HIPK3	100	8
p38 alpha MAPK	101	1
p38 gamma MAPK	101	3
PRAK	102	0
PAK2	103	2
PKD1	104	2
MKK6	104	9
Src	105	13
EPH-B3	105	7
MST4	105	0
PDK1	105	5
p38 delta MAPK	106	6
EF2K	109	12
SRPK1	116	5

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
PKB beta	69	15
PAK4	75	5
MST2	79	0
MELK	80	8
JAK2	81	2
PRAK	81	7
TAK1	81	14
MKK1	83	6
JNK2	83	6
MSK1	84	12
S6K1	84	2
ROCK 2	85	10
MARK3	85	0
PAK6	85	5
DAPK1	85	7
EPH-A2	86	5
PIM2	86	5
SmMLCK	87	9
BTK	87	7
MAPKAP-K3	88	3
IKK epsilon	88	7
TBK1	88	4
VEGFR1	88	0
PIM3	89	7
SGK1	90	5
MNK2	90	10
HIPK1	91	8
RSK2	91	3
CAMKK beta	92	5
PKD1	92	2
CSK	92	5
JNK3	93	15
IR	93	5
p38 gamma MAPK	94	7
PRK2	95	13
DYRK1A	95	0
IRR	95	2
NEK2a	95	10
MST4	95	6
CHK1	96	11
EPH-B1	96	5
DYRK2	96	2
PDK1	97	2
PKC alpha	97	3
ASK1	97	0
PKC zeta	97	7
PLK1	97	6
AMPK	98	11
MARK4	98	6
PAK2	98	1
DYRK3	98	2
MAPKAP-K2	99	9
p38 beta MAPK	99	11
JNK1	100	8
CDK2-Cyclin A	100	7
FGF-R1	100	12
p38 delta MAPK	100	12
RSK1	101	9
NUAK1	101	4
EPH-B4	101	5
RIPK2	101	10
Src	101	5
PAK5	101	0
EF2K	101	12
HIPK2	102	10
MARK2	102	2
PIM1	102	7
BRSK2	102	3
YES1	102	4
LKB1	102	4
MKK2	103	12
MLK3	103	5
PKB alpha	103	8
CLK2	103	11
GSK3 beta	104	6
CK2	104	6
TAO1	104	9
ERK2	104	12
PKA	104	7
MNK1	105	12
MINK1	106	9
IRAK4	106	1
TTK	106	7
Lck	106	2
Aurora B	106	7
ERK8	106	12
NEK6	106	10
EPH-A4	107	2
EPH-B2	107	11
SRPK1	107	2
TrkA	107	9
GCK	108	2
CAMK1	108	11
ERK1	108	6
MKK6	109	2
PHK	109	4
MLK1	110	2
p38 alpha MAPK	110	5
HER4	111	3
IKK beta	112	5
EPH-B3	112	13
MARK1	113	0
MEKK1	114	3
Aurora A	114	10
BRSK1	115	8
SYK	116	6
IGF-1R	116	8
HIPK3	117	10
CK1 delta	119	1
CHK2	122	8

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
MKK1	72	2
MELK	75	4
p38 beta MAPK	77	1
CHK1	78	5
PAK4	78	4
IR	79	6
IRR	80	2
CHK2	81	8
CLK2	81	5
VEGFR1	81	6
PIM3	83	5
S6K1	84	9
CDK2-Cyclin A	84	11
RIPK2	84	14
JAK2	84	10
SGK1	85	1
SmMLCK	85	4
HIPK1	85	6
GSK3 beta	85	13
IGF-1R	85	13
LKB1	85	0
AMPK	85	5
PKB beta	86	2
MINK1	86	4
CAMK1	87	3
ERK1	87	8
ROCK 2	87	7
ASK1	87	4
NEK2a	87	2
RSK1	87	3
BRSK2	88	1
DYRK1A	88	1
Aurora B	88	6
MARK1	88	4
Aurora A	89	9
DYRK3	89	3
Src	89	3
ERK8	89	6
DAPK1	90	12
TAO1	90	3
MSK1	90	2
p38 delta MAPK	90	10
TrkA	90	4
RSK2	90	10
IKK epsilon	90	12
PKA	91	0
JNK3	91	1
CSK	91	5
CK2	92	1
IRAK4	92	4
PKD1	92	6
MLK1	93	8
EPH-B2	93	2
PIM1	93	11
JNK2	94	1
PKC alpha	94	0
PAK2	94	3
p38 gamma MAPK	94	4
EPH-A2	95	6
FGF-R1	95	12
HER4	95	2
ERK2	96	11
PRK2	96	8
DYRK2	96	3
PAK5	96	15
BTK	96	6
PRAK	96	4
PKB alpha	96	0
MLK3	97	6
HIPK2	97	11
p38 alpha MAPK	97	9
MST2	97	5
MARK2	97	1
GCK	97	3
MKK6	98	4
PHK	98	4
NEK6	98	0
IKK beta	98	5
MKK2	99	12
EPH-B3	99	2
YES1	99	3
CAMKK beta	99	8
MARK3	99	1
JNK1	100	3
CK1 delta	100	5
HIPK3	100	8
MNK2	100	1
PAK6	100	14
SYK	100	6
MEKK1	101	5
MARK4	102	6
NUAK1	102	13
TBK1	102	1
MST4	103	1
EF2K	104	0
MNK1	104	5
PIM2	105	10
EPH-B4	105	5
PKC zeta	105	0
PLK1	105	6
TTK	105	3
SRPK1	106	3
TAK1	107	6
MAPKAP-K3	107	9
PDK1	107	1
EPH-B1	109	1
MAPKAP-K2	110	8
BRSK1	112	1
Lck	112	0
EPH-A4	116	9