Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
GSK650394A | C25H22N2O2 | 382.45 | 890842-28-1 | 25022668 | SGK | Sherk A. B. (2008) Cancer Res 68 7475–7483 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 49 | 6 |
ASK1 | 100 | 4 |
Aurora A | 78 | 4 |
Aurora B | 85 | 9 |
BRSK1 | 84 | 6 |
BRSK2 | 86 | 0 |
BTK | 89 | 3 |
CAMK1 | 104 | 4 |
CAMKK beta | 11 | 1 |
CDK2-Cyclin A | 106 | 11 |
CHK1 | 112 | 2 |
CHK2 | 83 | 0 |
CK1 delta | 70 | 4 |
CK2 | 96 | 1 |
CLK2 | 65 | 1 |
CSK | 99 | 9 |
DAPK1 | 87 | 3 |
DYRK1A | 79 | 7 |
DYRK2 | 101 | 4 |
DYRK3 | 79 | 8 |
EF2K | 120 | 7 |
EPH-A2 | 92 | 6 |
EPH-A4 | 103 | 7 |
EPH-B1 | 94 | 2 |
EPH-B2 | 86 | 10 |
EPH-B3 | 108 | 5 |
EPH-B4 | 122 | 7 |
ERK1 | 105 | 4 |
ERK2 | 100 | 6 |
ERK8 | 23 | 0 |
FGF-R1 | 99 | 8 |
GCK |
8
|
0 |
GSK3 beta | 94 | 1 |
HER4 | 105 | 1 |
HIPK1 | 99 | 1 |
HIPK2 | 70 | 4 |
HIPK3 | 100 | 0 |
IGF-1R | 100 | 12 |
IKK beta | 94 | 8 |
IKK epsilon | 91 | 7 |
IR | 111 | 0 |
IRAK4 | 20 | 2 |
IRR | 98 | 2 |
JAK2 | 24 | 3 |
JNK1 | 81 | 1 |
JNK2 | 80 | 4 |
JNK3 | 73 | 0 |
Lck | 109 | 3 |
LKB1 | 86 | 2 |
MAPKAP-K2 | 107 | 5 |
MAPKAP-K3 | 101 | 1 |
MARK1 | 97 | 4 |
MARK2 | 88 | 6 |
MARK3 | 89 | 6 |
MARK4 | 110 | 8 |
MEKK1 | 92 | 1 |
MELK | 100 | 3 |
MINK1 | 68 | 0 |
MKK1 | 105 | 8 |
MKK2 | 93 | 4 |
MKK6 | 97 | 4 |
MLK1 | 87 | 7 |
MLK3 | 75 | 2 |
MNK1 | 28 | 2 |
MNK2 | 68 | 5 |
MSK1 | 94 | 2 |
MST2 | 68 | 6 |
MST4 | 81 | 1 |
NEK2a | 114 | 3 |
NEK6 | 104 | 2 |
NUAK1 | 45 | 3 |
p38 alpha MAPK | 94 | 4 |
p38 beta MAPK | 109 | 5 |
p38 delta MAPK | 118 | 7 |
p38 gamma MAPK | 106 | 7 |
PAK2 | 99 | 11 |
PAK4 | 96 | 1 |
PAK5 | 110 | 3 |
PAK6 | 102 | 5 |
PDK1 | 94 | 5 |
PHK | 34 | 0 |
PIM1 | 91 | 5 |
PIM2 | 104 | 0 |
PIM3 | 90 | 1 |
PKA | 91 | 0 |
PKB alpha | 104 | 0 |
PKB beta | 86 | 9 |
PKC alpha | 100 | 4 |
PKC zeta | 96 | 4 |
PKD1 | 103 | 2 |
PLK1 | 93 | 1 |
PRAK | 107 | 6 |
PRK2 | 76 | 10 |
RIPK2 | 55 | 0 |
ROCK 2 | 84 | 5 |
RSK1 | 102 | 2 |
RSK2 | 96 | 7 |
S6K1 | 100 | 4 |
SGK1 | 56 | 3 |
SmMLCK | 87 | 0 |
Src | 93 | 6 |
SRPK1 | 82 | 2 |
SYK | 99 | 0 |
TAK1 | 115 | 10 |
TAO1 | 98 | 7 |
TBK1 | 86 | 2 |
TrkA | 29 | 2 |
TTK | 89 | 2 |
VEGFR1 | 98 | 8 |
YES1 | 105 | 7 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK |
2
|
0 |
Aurora B | 32 | 0 |
BRSK2 | 61 | 6 |
BTK | 96 | 5 |
CAMK1 | 99 | 4 |
CAMKK beta |
2
|
0 |
CDK2-Cyclin A |
1
|
0 |
CHK1 | 108 | 10 |
CHK2 | 40 | 4 |
CK1 delta | 12 | 0 |
CK2 | 82 | 25 |
CSK | 96 | 9 |
DYRK1A | 47 | 1 |
DYRK2 | 20 | 0 |
DYRK3 | 57 | 4 |
EF2K | 110 | 9 |
EPH-A2 | 97 | 0 |
EPH-B3 | 107 | 33 |
ERK1 | 75 | 7 |
ERK2 | 103 | 1 |
ERK8 | 32 | 0 |
FGF-R1 | 77 | 0 |
GCK |
3
|
0 |
GSK3 beta | 78 | 3 |
HER4 | 86 | 0 |
HIPK2 | 58 | 3 |
IGF-1R | 103 | 6 |
IKK beta | 97 | 12 |
IKK epsilon | 44 | 2 |
IR | 100 | 5 |
IRAK4 | 12 | 3 |
IRR | 58 | 9 |
JNK1 | 74 | 7 |
JNK2 | 46 | 10 |
Lck | 79 | 1 |
LKB1 | 89 | 9 |
MAPKAP-K2 | 103 | 5 |
MARK3 | 60 | 0 |
MELK | 27 | 1 |
MINK1 | 19 | 2 |
MKK1 | 34 | 2 |
MLK1 | 38 | 6 |
MLK3 | 33 | 4 |
MNK1 |
3
|
0 |
MNK2 | 14 | 2 |
MSK1 | 103 | 0 |
MST2 | 22 | 0 |
MST4 | 68 | 8 |
NEK2a | 60 | 9 |
NEK6 | 107 | 23 |
NUAK1 | 15 | 4 |
p38 alpha MAPK | 119 | 14 |
p38 beta MAPK | 112 | 8 |
p38 delta MAPK | 87 | 2 |
p38 gamma MAPK | 104 | 14 |
PAK4 | 85 | 13 |
PAK5 | 88 | 0 |
PAK6 | 103 | 1 |
PDK1 | 85 | 0 |
PHK |
3
|
0 |
PIM1 | 62 | 8 |
PIM2 | 92 | 11 |
PIM3 | 86 | 1 |
PKA | 104 | 12 |
PKB alpha | 72 | 4 |
PKB beta | 98 | 4 |
PKC alpha | 61 | 11 |
PKC zeta | 105 | 4 |
PKD1 | 55 | 1 |
PLK1 | 31 | 7 |
PRAK | 77 | 12 |
PRK2 | 31 | 1 |
ROCK 2 | 59 | 3 |
RSK1 | 93 | 5 |
RSK2 | 97 | 1 |
S6K1 | 74 | 9 |
SGK1 |
9
|
1 |
SmMLCK | 102 | 2 |
Src | 102 | 8 |
SRPK1 | 104 | 4 |
SYK | 66 | 11 |
TBK1 | 70 | 10 |
TTK | 79 | 3 |
VEGFR1 | 63 | 6 |
YES1 | 93 | 1 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK |
1
|
0 |
Aurora B |
6
|
0 |
BRSK2 | 20 | 3 |
BTK | 70 | 33 |
CAMK1 | 80 | 12 |
CAMKK beta |
2
|
0 |
CDK2-Cyclin A |
0
|
0 |
CHK1 | 79 | 3 |
CHK2 | 28 | 3 |
CK1 delta |
3
|
0 |
CK2 | 46 | 11 |
CSK | 98 | 2 |
DYRK1A |
8
|
0 |
DYRK2 |
2
|
0 |
DYRK3 | 17 | 4 |
EF2K | 108 | 21 |
EPH-A2 | 85 | 3 |
EPH-B3 | 101 | 13 |
ERK1 | 39 | 2 |
ERK2 | 61 | 0 |
ERK8 | 23 | 10 |
FGF-R1 | 27 | 4 |
GCK |
1
|
0 |
GSK3 beta | 23 | 10 |
HER4 | 71 | 9 |
HIPK2 | 15 | 3 |
IGF-1R | 18 | 0 |
IKK beta | 64 | 7 |
IKK epsilon | 14 | 3 |
IR | 68 | 16 |
IRAK4 | 12 | 1 |
IRR | 26 | 2 |
JNK1 | 39 | 7 |
JNK2 |
9
|
1 |
Lck | 45 | 22 |
LKB1 | 61 | 21 |
MAPKAP-K2 | 96 | 7 |
MARK3 | 29 | 15 |
MELK |
8
|
0 |
MINK1 |
2
|
0 |
MKK1 | 12 | 2 |
MLK1 |
7
|
2 |
MLK3 |
5
|
0 |
MNK1 |
3
|
1 |
MNK2 |
4
|
1 |
MSK1 | 62 | 3 |
MST2 |
4
|
0 |
MST4 | 13 | 0 |
NEK2a | 27 | 5 |
NEK6 | 107 | 14 |
NUAK1 |
10
|
5 |
p38 alpha MAPK | 106 | 3 |
p38 beta MAPK | 71 | 1 |
p38 delta MAPK | 62 | 1 |
p38 gamma MAPK | 35 | 8 |
PAK4 | 39 | 2 |
PAK5 | 38 | 10 |
PAK6 | 61 | 6 |
PDK1 | 31 | 5 |
PHK |
0
|
0 |
PIM1 | 26 | 1 |
PIM2 | 75 | 2 |
PIM3 | 45 | 3 |
PKA | 97 | 5 |
PKB alpha | 57 | 11 |
PKB beta | 74 | 8 |
PKC alpha | 33 | 6 |
PKC zeta | 87 | 0 |
PKD1 | 16 | 0 |
PLK1 |
5
|
0 |
PRAK | 73 | 5 |
PRK2 |
5
|
1 |
ROCK 2 | 33 | 16 |
RSK1 | 38 | 4 |
RSK2 | 57 | 21 |
S6K1 | 24 | 1 |
SGK1 |
1
|
0 |
SmMLCK | 87 | 0 |
Src | 44 | 0 |
SRPK1 | 50 | 0 |
SYK | 12 | 1 |
TBK1 | 27 | 3 |
TTK | 46 | 3 |
VEGFR1 | 15 | 0 |
YES1 | 42 | 2 |