Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
IRAK 1-4 Inhibitor 1 | C20H21N5O4 | 395.41 | 509093-47-4 | 11983295 | IRAK1, IRAK4 | Powers J. P. (2006) Bioorg. Med. Chem. Lett. 16 2842-2845 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 89 | 15 |
AMPK (hum) | 115 | 1 |
ASK1 | 82 | 18 |
Aurora A | 110 | 3 |
Aurora B | 112 | 3 |
BRK | 89 | 1 |
BRSK1 | 107 | 7 |
BRSK2 | 86 | 29 |
BTK | 74 | 27 |
CAMK1 | 98 | 12 |
CAMKK beta | 55 | 3 |
CDK2-Cyclin A | 84 | 4 |
CDK9-Cyclin T1 | 42 | 1 |
CHK1 | 81 | 29 |
CHK2 | 97 | 11 |
CK1 delta | 48 | 1 |
CK1 gamma 2 | 48 | 5 |
CK2 | 112 | 9 |
CLK2 |
6
|
2 |
CSK | 89 | 4 |
DAPK1 | 127 | 2 |
DDR2 | 107 | 18 |
DYRK1A | 48 | 12 |
DYRK2 | 93 | 6 |
DYRK3 | 89 | 4 |
EF2K | 114 | 1 |
EIF2AK3 | 98 | 3 |
EPH-A2 | 100 | 12 |
EPH-A4 | 90 | 2 |
EPH-B1 | 99 | 10 |
EPH-B2 | 69 | 1 |
EPH-B3 | 133 | 25 |
EPH-B4 | 100 | 6 |
ERK1 | 130 | 1 |
ERK2 | 101 | 13 |
ERK5 | 81 | 2 |
ERK8 | 105 | 9 |
FGF-R1 | 120 | 12 |
GCK | 82 | 1 |
GSK3 beta | 71 | 1 |
HER4 | 103 | 10 |
HIPK1 | 87 | 2 |
HIPK2 | 78 | 3 |
HIPK3 | 87 | 11 |
IGF-1R | 82 | 10 |
IKK beta | 82 | 5 |
IKK epsilon | 90 | 3 |
IR | 81 | 9 |
IRAK1 |
6
|
2 |
IRAK4 |
9
|
3 |
IRR | 71 | 1 |
JAK2 | 70 | 7 |
JNK1 | 103 | 8 |
JNK2 | 96 | 1 |
JNK3 | 87 | 5 |
Lck | 94 | 8 |
LKB1 | 74 | 4 |
MAP4K3 | 69 | 5 |
MAP4K5 | 75 | 0 |
MAPKAP-K2 | 91 | 0 |
MAPKAP-K3 | 99 | 5 |
MARK1 | 91 | 5 |
MARK2 | 93 | 4 |
MARK3 | 92 | 1 |
MARK4 | 95 | 6 |
MEKK1 | 92 | 4 |
MELK | 86 | 0 |
MINK1 | 51 | 2 |
MKK1 | 71 | 7 |
MKK2 | 92 | 16 |
MKK6 | 104 | 13 |
MLK1 | 65 | 1 |
MLK3 | 54 | 4 |
MNK1 | 88 | 1 |
MNK2 | 64 | 15 |
MPSK1 | 82 | 4 |
MSK1 | 96 | 4 |
MST2 | 99 | 5 |
MST3 | 99 | 11 |
MST4 | 96 | 8 |
NEK2a | 80 | 31 |
NEK6 | 117 | 2 |
NUAK1 | 63 | 3 |
OSR1 | 106 | 4 |
p38 alpha MAPK | 99 | 5 |
p38 beta MAPK | 117 | 3 |
p38 delta MAPK | 118 | 26 |
p38 gamma MAPK | 83 | 18 |
PAK2 | 94 | 8 |
PAK4 | 61 | 2 |
PAK5 | 76 | 8 |
PAK6 | 87 | 4 |
PDGFRA | 98 | 6 |
PDK1 | 97 | 14 |
PHK | 71 | 8 |
PIM1 | 97 | 0 |
PIM2 | 100 | 13 |
PIM3 | 85 | 5 |
PINK | 106 | 5 |
PKA | 91 | 2 |
PKB alpha | 104 | 1 |
PKB beta | 86 | 2 |
PKC alpha | 100 | 4 |
PKC gamma | 88 | 1 |
PKC zeta | 92 | 16 |
PKD1 | 82 | 5 |
PLK1 | 70 | 1 |
PRAK | 96 | 1 |
PRK2 | 94 | 3 |
RIPK2 | 109 | 19 |
ROCK 2 | 82 | 6 |
RSK1 | 81 | 12 |
RSK2 | 74 | 3 |
S6K1 | 88 | 6 |
SGK1 | 73 | 11 |
SIK2 | 84 | 5 |
SIK3 | 99 | 25 |
SmMLCK | 115 | 14 |
Src | 109 | 9 |
SRPK1 | 91 | 7 |
STK33 | 94 | 1 |
SYK | 100 | 10 |
TAK1 | 28 | 2 |
TAO1 | 88 | 3 |
TBK1 | 67 | 8 |
TESK1 | 99 | 2 |
TGFBR1 | 112 | 1 |
TIE2 | 80 | 16 |
TLK1 | 92 | 1 |
TrkA | 20 | 3 |
TSSK1 | 97 | 15 |
TTBK1 | 95 | 1 |
TTBK2 | 118 | 7 |
TTK | 73 | 2 |
ULK1 | 101 | 10 |
ULK2 | 96 | 4 |
VEGFR1 | 84 | 7 |
WNK1 | 94 | 5 |
YES1 | 102 | 5 |
ZAP70 | 117 | 5 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 90 | 5 |
AMPK (hum) | 107 | 6 |
ASK1 | 84 | 24 |
Aurora A | 98 | 3 |
Aurora B | 102 | 4 |
BRK | 82 | 4 |
BRSK1 | 104 | 17 |
BRSK2 | 107 | 38 |
BTK | 52 | 3 |
CAMK1 | 93 | 14 |
CAMKK beta | 68 | 8 |
CDK2-Cyclin A | 62 | 11 |
CDK9-Cyclin T1 | 14 | 3 |
CHK1 | 102 | 8 |
CHK2 | 90 | 7 |
CK1 delta | 47 | 3 |
CK1 gamma 2 | 17 | 9 |
CK2 | 104 | 4 |
CLK2 |
4
|
1 |
CSK | 76 | 2 |
DAPK1 | 116 | 13 |
DDR2 | 98 | 0 |
DYRK1A | 51 | 14 |
DYRK2 | 84 | 4 |
DYRK3 | 79 | 6 |
EF2K | 102 | 5 |
EIF2AK3 | 100 | 4 |
EPH-A2 | 107 | 4 |
EPH-A4 | 71 | 1 |
EPH-B1 | 93 | 4 |
EPH-B2 | 47 | 24 |
EPH-B3 | 80 | 12 |
EPH-B4 | 94 | 9 |
ERK1 | 125 | 8 |
ERK2 | 90 | 8 |
ERK5 | 66 | 3 |
ERK8 | 72 | 1 |
FGF-R1 | 117 | 16 |
GCK | 29 | 2 |
GSK3 beta | 67 | 2 |
HER4 | 97 | 6 |
HIPK1 | 77 | 14 |
HIPK2 | 72 | 6 |
HIPK3 | 67 | 12 |
IGF-1R | 61 | 0 |
IKK beta | 74 | 4 |
IKK epsilon | 83 | 5 |
IR | 60 | 8 |
IRAK1 |
6
|
5 |
IRAK4 | 12 | 1 |
IRR | 56 | 15 |
JAK2 | 63 | 10 |
JNK1 | 66 | 3 |
JNK2 | 81 | 6 |
JNK3 | 41 | 1 |
Lck | 89 | 11 |
LKB1 | 75 | 1 |
MAP4K3 | 14 | 2 |
MAP4K5 | 31 | 1 |
MAPKAP-K2 | 76 | 14 |
MAPKAP-K3 | 87 | 7 |
MARK1 | 87 | 17 |
MARK2 | 82 | 15 |
MARK3 | 82 | 8 |
MARK4 | 70 | 1 |
MEKK1 | 88 | 9 |
MELK | 45 | 6 |
MINK1 |
10
|
1 |
MKK1 | 77 | 11 |
MKK2 | 73 | 4 |
MKK6 | 104 | 10 |
MLK1 | 20 | 3 |
MLK3 | 39 | 1 |
MNK1 | 98 | 7 |
MNK2 | 79 | 2 |
MPSK1 | 41 | 1 |
MSK1 | 92 | 7 |
MST2 | 100 | 17 |
MST3 | 83 | 3 |
MST4 | 105 | 16 |
NEK2a | 89 | 22 |
NEK6 | 115 | 5 |
NUAK1 | 34 | 10 |
OSR1 | 97 | 5 |
p38 alpha MAPK | 96 | 7 |
p38 beta MAPK | 110 | 42 |
p38 delta MAPK | 112 | 9 |
p38 gamma MAPK | 73 | 5 |
PAK2 | 90 | 3 |
PAK4 | 50 | 10 |
PAK5 | 45 | 2 |
PAK6 | 63 | 13 |
PDGFRA | 85 | 20 |
PDK1 | 104 | 9 |
PHK | 60 | 15 |
PIM1 | 100 | 5 |
PIM2 | 102 | 19 |
PIM3 | 81 | 10 |
PINK | 99 | 8 |
PKA | 95 | 2 |
PKB alpha | 97 | 7 |
PKB beta | 85 | 3 |
PKC alpha | 103 | 6 |
PKC gamma | 86 | 1 |
PKC zeta | 76 | 18 |
PKD1 | 84 | 13 |
PLK1 | 75 | 2 |
PRAK | 94 | 7 |
PRK2 | 88 | 0 |
RIPK2 | 93 | 13 |
ROCK 2 | 82 | 8 |
RSK1 | 73 | 13 |
RSK2 | 69 | 4 |
S6K1 | 81 | 1 |
SGK1 | 79 | 6 |
SIK2 | 74 | 3 |
SIK3 | 72 | 3 |
SmMLCK | 114 | 3 |
Src | 116 | 1 |
SRPK1 | 91 | 5 |
STK33 | 48 | 1 |
SYK | 97 | 2 |
TAK1 | 23 | 8 |
TAO1 | 90 | 8 |
TBK1 | 99 | 12 |
TESK1 | 95 | 1 |
TGFBR1 | 99 | 8 |
TIE2 | 83 | 13 |
TLK1 | 77 | 9 |
TrkA | 22 | 0 |
TSSK1 | 90 | 3 |
TTBK1 | 91 | 4 |
TTBK2 | 117 | 5 |
TTK | 72 | 2 |
ULK1 | 82 | 5 |
ULK2 | 90 | 3 |
VEGFR1 | 83 | 9 |
WNK1 | 98 | 4 |
YES1 | 59 | 1 |
ZAP70 | 106 | 1 |