Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Wyeth PDK1 Inhibitor Compound 1 | C19H22Cl4N4O2 | 480.21 | PDK1 | Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 46 | 1 |
ASK1 | 67 | 7 |
Aurora A | 103 | 8 |
Aurora B | 97 | 5 |
BRSK1 | 82 | 1 |
BRSK2 | 84 | 5 |
BTK | 87 | 1 |
CAMK1 | 91 | 1 |
CAMKK beta | 87 | 5 |
CDK2-Cyclin A | 74 | 2 |
CHK1 | 53 | 3 |
CHK2 | 46 | 14 |
CK1 delta | 83 | 1 |
CK2 | 89 | 7 |
CLK2 | 61 | 4 |
CSK | 85 | 5 |
DAPK1 | 81 | 1 |
DYRK1A | 100 | 1 |
DYRK2 | 91 | 11 |
DYRK3 | 89 | 2 |
EF2K | 83 | 3 |
EPH-A2 | 109 | 14 |
EPH-A4 | 95 | 2 |
EPH-B1 | 105 | 3 |
EPH-B2 | 112 | 3 |
EPH-B3 | 93 | 13 |
EPH-B4 | 98 | 0 |
ERK1 | 72 | 3 |
ERK2 | 69 | 3 |
ERK8 | 85 | 6 |
FGF-R1 | 76 | 0 |
GCK | 11 | 0 |
GSK3 beta | 64 | 2 |
HER4 | 73 | 5 |
HIPK1 | 78 | 1 |
HIPK2 | 56 | 1 |
HIPK3 | 98 | 0 |
IGF-1R | 99 | 4 |
IKK beta | 56 | 6 |
IKK epsilon |
8
|
0 |
IR | 65 | 12 |
IRAK4 | 61 | 0 |
IRR | 73 | 2 |
JAK2 | 14 | 1 |
JNK1 | 90 | 3 |
JNK2 | 91 | 10 |
JNK3 | 97 | 6 |
Lck | 84 | 11 |
LKB1 | 77 | 4 |
MAPKAP-K2 | 101 | 5 |
MAPKAP-K3 | 94 | 6 |
MARK1 | 55 | 3 |
MARK2 | 73 | 3 |
MARK3 | 35 | 0 |
MARK4 | 65 | 7 |
MEKK1 | 51 | 9 |
MELK | 71 | 3 |
MINK1 | 15 | 2 |
MKK1 |
10
|
0 |
MKK2 | 34 | 4 |
MKK6 | 95 | 2 |
MLK1 | 26 | 2 |
MLK3 |
8
|
1 |
MNK1 | 114 | 9 |
MNK2 | 123 | 3 |
MSK1 | 82 | 5 |
MST2 | 15 | 1 |
MST4 | 32 | 0 |
NEK2a | 55 | 6 |
NEK6 | 99 | 6 |
NUAK1 | 30 | 1 |
p38 alpha MAPK | 100 | 3 |
p38 beta MAPK | 95 | 4 |
p38 delta MAPK | 92 | 1 |
p38 gamma MAPK | 98 | 9 |
PAK2 | 77 | 7 |
PAK4 | 72 | 3 |
PAK5 | 76 | 7 |
PAK6 | 64 | 0 |
PDK1 | 35 | 4 |
PHK | 69 | 2 |
PIM1 | 94 | 7 |
PIM2 | 91 | 7 |
PIM3 | 72 | 6 |
PKA | 86 | 1 |
PKB alpha | 94 | 9 |
PKB beta | 86 | 3 |
PKC alpha | 79 | 4 |
PKC zeta | 89 | 3 |
PKD1 | 19 | 5 |
PLK1 | 79 | 5 |
PRAK | 86 | 3 |
PRK2 | 71 | 2 |
RIPK2 | 82 | 6 |
ROCK 2 | 54 | 1 |
RSK1 | 14 | 1 |
RSK2 | 15 | 1 |
S6K1 | 82 | 5 |
SGK1 | 98 | 2 |
SmMLCK | 77 | 2 |
Src | 86 | 2 |
SRPK1 | 96 | 7 |
SYK | 74 | 5 |
TAK1 | 41 | 7 |
TAO1 | 59 | 2 |
TBK1 | 11 | 0 |
TrkA | 73 | 4 |
TTK | 68 | 1 |
VEGFR1 | 47 | 5 |
YES1 | 81 | 1 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 20 | 3 |
ASK1 | 21 | 1 |
Aurora A | 82 | 3 |
Aurora B | 68 | 6 |
BRSK1 | 67 | 6 |
BRSK2 | 77 | 6 |
BTK | 70 | 7 |
CAMK1 | 82 | 3 |
CAMKK beta | 91 | 2 |
CDK2-Cyclin A | 69 | 8 |
CHK1 | 20 | 1 |
CHK2 |
7
|
2 |
CK1 delta | 70 | 5 |
CK2 | 75 | 1 |
CLK2 | 27 | 0 |
CSK | 88 | 1 |
DAPK1 | 59 | 8 |
DYRK1A | 55 | 2 |
DYRK2 | 78 | 1 |
DYRK3 | 71 | 2 |
EF2K | 77 | 3 |
EPH-A2 | 99 | 7 |
EPH-A4 | 87 | 2 |
EPH-B1 | 102 | 0 |
EPH-B2 | 105 | 8 |
EPH-B3 | 91 | 1 |
EPH-B4 | 95 | 1 |
ERK1 | 31 | 2 |
ERK2 | 58 | 7 |
ERK8 | 48 | 1 |
FGF-R1 | 49 | 0 |
GCK |
4
|
1 |
GSK3 beta | 32 | 2 |
HER4 | 46 | 3 |
HIPK1 | 53 | 3 |
HIPK2 | 23 | 7 |
HIPK3 | 69 | 5 |
IGF-1R | 72 | 10 |
IKK beta | 31 | 0 |
IKK epsilon |
9
|
1 |
IR | 32 | 4 |
IRAK4 | 46 | 4 |
IRR | 54 | 2 |
JAK2 |
6
|
1 |
JNK1 | 80 | 8 |
JNK2 | 94 | 8 |
JNK3 | 63 | 4 |
Lck | 65 | 11 |
LKB1 | 84 | 11 |
MAPKAP-K2 | 97 | 0 |
MAPKAP-K3 | 79 | 3 |
MARK1 | 34 | 2 |
MARK2 | 72 | 9 |
MARK3 | 18 | 3 |
MARK4 | 40 | 7 |
MEKK1 | 40 | 11 |
MELK | 61 | 3 |
MINK1 |
7
|
2 |
MKK1 |
2
|
3 |
MKK2 | 16 | 3 |
MKK6 | 100 | 1 |
MLK1 | 27 | 2 |
MLK3 |
4
|
1 |
MNK1 | 90 | 3 |
MNK2 | 115 | 2 |
MSK1 | 71 | 5 |
MST2 |
4
|
1 |
MST4 | 14 | 1 |
NEK2a | 18 | 3 |
NEK6 | 95 | 3 |
NUAK1 | 25 | 7 |
p38 alpha MAPK | 116 | 7 |
p38 beta MAPK | 90 | 1 |
p38 delta MAPK | 84 | 13 |
p38 gamma MAPK | 109 | 8 |
PAK2 | 50 | 1 |
PAK4 | 42 | 5 |
PAK5 | 38 | 0 |
PAK6 | 56 | 3 |
PDK1 | 14 | 1 |
PHK | 26 | 1 |
PIM1 | 69 | 3 |
PIM2 | 95 | 1 |
PIM3 | 29 | 4 |
PKA | 77 | 1 |
PKB alpha | 84 | 0 |
PKB beta | 64 | 2 |
PKC alpha | 62 | 5 |
PKC zeta | 115 | 4 |
PKD1 |
10
|
1 |
PLK1 | 45 | 2 |
PRAK | 82 | 8 |
PRK2 | 34 | 3 |
RIPK2 | 70 | 6 |
ROCK 2 | 15 | 4 |
RSK1 |
2
|
1 |
RSK2 |
9
|
0 |
S6K1 | 57 | 6 |
SGK1 | 86 | 2 |
SmMLCK | 56 | 2 |
Src | 89 | 10 |
SRPK1 | 105 | 10 |
SYK | 43 | 4 |
TAK1 |
5
|
2 |
TAO1 | 28 | 6 |
TBK1 | 17 | 7 |
TrkA | 56 | 4 |
TTK | 44 | 1 |
VEGFR1 | 23 | 1 |
YES1 | 57 | 0 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 25 | 21 |
BRSK2 | 74 | 5 |
BTK | 49 | 1 |
CAMK1 | 17 | 5 |
CAMKK beta | 71 | 4 |
CDK2-Cyclin A | 58 | 3 |
CHK1 |
2
|
1 |
CHK2 | 13 | 2 |
CK1 delta | 46 | 2 |
CK2 | 80 | 2 |
CSK | 78 | 5 |
DYRK1A | 55 | 5 |
DYRK2 | 51 | 5 |
DYRK3 | 53 | 3 |
EF2K | 103 | 7 |
EPH-A2 | 70 | 1 |
EPH-B3 | 34 | 0 |
ERK1 | 48 | 1 |
ERK2 | 49 | 7 |
ERK8 | 18 | 1 |
FGF-R1 | 30 | 0 |
GSK3 beta | 24 | 0 |
HIPK2 | 41 | 0 |
IGF-1R | 38 | 7 |
IKK beta | 50 | 1 |
IKK epsilon |
6
|
0 |
IR | 53 | 2 |
IRR | 36 | 4 |
JNK1 | 80 | 19 |
JNK2 | 86 | 1 |
Lck | 24 | 2 |
MAPKAP-K2 | 105 | 55 |
MARK3 |
5
|
0 |
MELK | 34 | 13 |
MKK1 |
6
|
4 |
MNK1 | 99 | 12 |
MNK2 | 93 | 2 |
MSK1 | 59 | 8 |
MST2 |
1
|
0 |
MST4 | 35 | 7 |
NEK2a |
6
|
1 |
NEK6 | 79 | 8 |
p38 alpha MAPK | 108 | 7 |
p38 beta MAPK | 84 | 15 |
p38 delta MAPK | 87 | 8 |
p38 gamma MAPK | 86 | 3 |
PAK4 | 21 | 0 |
PAK5 | 25 | 1 |
PAK6 | 54 | 2 |
PDK1 |
3
|
1 |
PHK | 13 | 0 |
PIM1 | 36 | 12 |
PIM2 | 88 | 4 |
PIM3 | 21 | 1 |
PKA | 53 | 8 |
PKB alpha | 93 | 5 |
PKB beta | 88 | 5 |
PKC alpha | 23 | 1 |
PKC zeta | 37 | 2 |
PKD1 |
2
|
2 |
PLK1 | 26 | 5 |
PRAK | 36 | 0 |
PRK2 | 16 | 1 |
ROCK 2 | 14 | 2 |
RSK1 |
3
|
0 |
RSK2 |
4
|
0 |
S6K1 | 34 | 0 |
SGK1 | 58 | 3 |
SmMLCK | 33 | 5 |
Src | 70 | 0 |
SRPK1 | 82 | 0 |
SYK | 37 | 2 |
TBK1 | 18 | 2 |
VEGFR1 | 20 | 12 |
YES1 | 64 | 9 |