Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
IPA-3   C20H14O2S2 350.45 PAK1 Deacon S.W. (2008) Chemistry and Biology 15 322
IRAK 1-4 Inhibitor 1   C20H21N5O4 395.41 IRAK1, IRAK4 Powers J. P. (2006) Bioorg. Med. Chem. Lett. 16 2842-2845
IRAK-4 kinase inhibitor a   C22H24N4O6 440.45 IRAK4 Wang Z. (2006) Structure 14 1835-1844
IRAK-4 kinase inhibitor b   C22H24N4O6 440.45 IRAK4
Ischemin   C15H17N3O4S 335.38 p53 CBP Jagat C. Borah (2011) Chemistry & Biology, 18 4 531-541
Ivosidenib   C28H22ClF3N6O3 583.00
JNKIN7   C28H27N7O2 493.56 JNK Zhang T. (2012) Chem Biol. 19(1) 140-54
JNKIN8   C29H29N7O2 507.59 JNK Zhang T. (2012) Chem Biol. 19(1) 140-54
K252a   C27H21N3O5 467.50 CaMKII Cools J. (2004) Cancer Res. 64 6385 Chin L.S. (1999) Cancer Invest. 17 391
Kalopanaxsaponin A   C41H66O12 750.96
Kenpaullone   C16H11BrN2O 327.20 GSK, CDK Bain J. (2003) Biochem. J. 371 199 Buolamwini J.K. (2000) Curr. Pharm. Des. 6 379
KIN 112   C32H36N6O4 568.67 Lck Martin M.W. (2006) J.Med.Chem. 49 4981-4991
KN62   C38H35N5O6S2 721.90 CaMKII Minami H. (1994) Biochem. Biophys. Res. Commun. 199 241
KN93   C26H29CIN2O4S 501.00 CaMKII Fan G.H. (1999) Mol. Pharmacol. 56 39 Tombes R.M. (1995) Cell Growth Differ. 6 1063
KT5720   C32H31N3O5 537.60 PKA Simpson CS. Morris BJ. (1995) Neuroscience 68 97-106 Cabell L. Audesirk G. (1993) Int. J. Dev. Neurosci. 11 357
KU 0063794   C25H31N5O4 465.54 mTOR Juan M. García-Martínez (2009) Biochem J. 421 29–42
KU 55933   C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152
KU55933   C21H17NO3S2 395.49 ATM Li Y. (2010) Mol. Cancer Ther. 2010 Jan. 9(1) 113-25
Lapatinib   C29H26ClFN4O4S EGFR, ERBB2
Larotrectinib   C21H22F2N6O2 428.40 TRKs