Inhibitor | A-769662  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
A-769662   C20H12N2O3S 360.39 844499-71-4 54708532 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 135 15
ASK1 140 5
Aurora A 93 7
Aurora B 53 0
BRSK1 76 5
BRSK2 64 4
BTK 52 5
CAMK1 68 3
CAMKK beta 87 5
CDK2-Cyclin A 100 3
CHK1 69 2
CHK2 79 4
CK1 delta 88 5
CK2 110 5
CLK2 81 2
CSK 79 2
DAPK1 107 1
DYRK1A 75 3
DYRK2 63 0
DYRK3 54 6
EF2K 89 4
EPH-A2 82 7
EPH-A4 93 1
EPH-B1 110 6
EPH-B2 93 5
EPH-B3 81 11
EPH-B4 82 8
ERK1 83 3
ERK2 103 8
ERK8 81 3
FGF-R1 109 11
GCK 76 5
GSK3 beta 80 1
HER4 33 7
HIPK1 74 7
HIPK2 99 6
HIPK3 97 1
IGF-1R 94 8
IKK beta 86 0
IKK epsilon 69 4
IR 103 1
IRAK4 82 4
IRR 88 5
JAK2 83 6
JNK1 99 5
JNK2 94 1
JNK3 75 3
Lck 88 5
LKB1 86 3
MAPKAP-K2 77 1
MAPKAP-K3 57 1
MARK1 59 3
MARK2 64 4
MARK3 78 4
MARK4 92 6
MEKK1 26 5
MELK 46 1
MINK1 65 6
MKK1 79 1
MKK2 74 3
MKK6 85 15
MLK1 59 4
MLK3 43 6
MNK1 104 2
MNK2 102 3
MSK1 69 3
MST2 60 10
MST4 74 5
NEK2a 73 1
NEK6 104 6
NUAK1 61 7
p38 alpha MAPK 97 2
p38 beta MAPK 89 2
p38 delta MAPK 107 7
p38 gamma MAPK 95 3
PAK2 94 2
PAK4 52 8
PAK5 58 2
PAK6 69 3
PDK1 93 3
PHK 96 0
PIM1 26 2
PIM2 71 5
PIM3 18 1
PKA 89 1
PKB alpha 94 0
PKB beta 56 5
PKC alpha 94 6
PKC zeta 96 7
PKD1 62 6
PLK1 88 1
PRAK 52 4
PRK2 85 8
RIPK2 110 4
ROCK 2 91 2
RSK1 80 7
RSK2 74 4
S6K1 78 1
SGK1 103 1
SmMLCK 76 2
Src 44 5
SRPK1 107 0
SYK 106 0
TAK1 83 3
TAO1 83 4
TBK1 67 8
TrkA 69 2
TTK 76 2
VEGFR1 65 4
YES1 96 7
Screen Conc: 50.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 67 3
Aurora B 25 2
Aurora C 30 4
BRSK2 63 4
CAMK1 45 0
CAMKK beta 48 9
CDK2-Cyclin A 84 6
CHK1 98 4
CHK2 52 4
CK1 delta 60 6
CK2 95 0
CSK 46 1
DYRK1A 60 10
DYRK2 84 0
DYRK3 47 4
EF2K 73 3
EPH-A2 64 6
ERK1 102 3
ERK2 74 2
ERK8 36 4
FGF-R1 95 11
GSK3 beta 17 4
HIPK2 58 2
HIPK3 52 2
IKK beta 60 0
IKK epsilon 47 1
IRR 90 4
JNK1 102 3
JNK2 89 10
JNK3 70 4
Lck 58 4
MAPKAP-K2 32 2
MAPKAP-K3 48 1
MARK3 87 4
MELK 64 5
MKK1 27 10
MNK1 66 4
MNK2 80 4
MSK1 39 4
MST2 36 0
MST4 57 3
NEK2a 52 9
NEK6 94 8
NEK7 102 4
p38 alpha MAPK 122 12
p38 beta MAPK 84 4
p38 delta MAPK 116 12
p38 gamma MAPK 80 6
PAK4 38 0
PAK5 50 6
PAK6 92 11
PDK1 81 0
PHK 65 3
PIM1
5
 0
PIM2 17 0
PIM3
5
 0
PKA 41 10
PKB alpha 62 1
PKB beta 37 5
PKC alpha 60 0
PKC zeta 67 6
PKD1 25 12
PLK1 28 1
PRAK 25 1
PRK2 85 9
ROCK 2 49 7
RSK1
9
 0
RSK2 27 7
S6K1 66 5
SGK1 54 1
SmMLCK 39 12
Src 65 13
SRPK1 42 8
SYK 36 3
TBK1 55 4
YES1 13 2
Screen Conc: 100.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 62 5
ASK1 250 7
Aurora A 64 4
Aurora B 22 2
BRSK1 51 4
BRSK2 28 1
BTK
10
 1
CAMK1
7
 1
CAMKK beta 78 4
CDK2-Cyclin A 121 0
CHK1 43 3
CHK2 33 3
CK1 delta 88 4
CK2 86 5
CLK2 30 4
CSK 82 10
DAPK1 83 5
DYRK1A 26 3
DYRK2 33 2
DYRK3
6
 1
EF2K 64 5
EPH-A2 40 5
EPH-A4 64 4
EPH-B1 97 4
EPH-B2 13 2
EPH-B3 55 4
EPH-B4 49 4
ERK1 63 11
ERK2 49 10
ERK8 24 4
FGF-R1 50 8
GCK 14 2
GSK3 beta 46 6
HER4
8
 4
HIPK1 35 2
HIPK2 19 3
HIPK3 43 6
IGF-1R 65 5
IKK beta 39 3
IKK epsilon 12 0
IR 69 9
IRAK4 34 3
IRR 51 6
JAK2 32 1
JNK1 93 8
JNK2 88 1
JNK3 62 11
Lck 58 5
LKB1 65 6
MAPKAP-K2 30 4
MAPKAP-K3
8
 3
MARK1 68 6
MARK2 49 2
MARK3 38 4
MARK4 45 4
MEKK1
7
 0
MELK 21 0
MINK1
5
 0
MKK1 29 3
MKK2 19 0
MKK6 84 10
MLK1 18 2
MLK3
4
 1
MNK1 93 5
MNK2 86 1
MSK1 42 7
MST2 20 0
MST4 14 0
NEK2a 19 0
NEK6 137 5
NUAK1
10
 0
p38 alpha MAPK 90 5
p38 beta MAPK 77 3
p38 delta MAPK 124 10
p38 gamma MAPK 83 6
PAK2 63 8
PAK4 41 2
PAK5 39 1
PAK6 82 8
PDK1 90 2
PHK 73 1
PIM1
7
 1
PIM2 18 1
PIM3
7
 2
PKA 95 10
PKB alpha 78 2
PKB beta 11 2
PKC alpha 90 11
PKC zeta 28 6
PKD1 24 1
PLK1 25 2
PRAK 15 4
PRK2 59 2
RIPK2 139 3
ROCK 2 75 5
RSK1 12 5
RSK2 13 2
S6K1 38 1
SGK1 48 1
SmMLCK 20 0
Src
10
 1
SRPK1 35 1
SYK 42 10
TAK1 72 8
TAO1 18 1
TBK1 29 2
TrkA 28 4
TTK 48 1
VEGFR1 11 2
YES1 16 0