Inhibitor | Amgen-NIK-28  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
MAP4K3
2
 1
MLK3
2
 0
PAK4
2
 2
PAK5
3
 1
HIPK1
3
 0
PAK6
5
 1
MAP4K5
5
 1
MLK1
5
 0
TAK1
6
 0
TAO1
7
 2
TTBK1
8
 1
PKD1
9
 3
JAK2
10
 2
MARK3
10
 1
TTBK2 12 5
TSSK1 13 0
CK1 delta 15 3
CHK2 16 3
MINK1 16 0
MKK1 22 2
VEGFR1 22 2
EIF2AK3 24 4
CLK2 27 5
IKK epsilon 28 10
GSK3 beta 30 2
SmMLCK 31 0
NUAK1 33 3
p38 gamma MAPK 34 1
GCK 37 1
MARK1 38 15
MKK2 39 7
HIPK2 39 2
MARK4 39 3
MARK2 42 1
MKK6 46 24
PKB beta 46 4
ERK5 47 3
STK33 52 0
IRAK4 53 10
PKB alpha 54 1
ULK2 61 7
DYRK3 61 2
FGF-R1 62 2
MST4 63 3
MST2 65 2
SGK1 68 0
CAMK1 69 12
MELK 71 2
AMPK (hum) 71 5
MST3 72 2
Aurora B 72 3
DYRK1A 72 13
IR 72 5
RIPK2 73 5
DYRK2 76 1
SIK2 77 5
PHK 80 3
ULK1 81 16
LKB1 81 6
RSK1 81 15
DAPK1 82 1
IKK beta 82 4
Src 82 10
EF2K 83 9
BRSK2 84 7
TGFBR1 84 9
ERK8 85 0
HIPK3 86 26
JNK1 86 17
JNK2 86 6
PRK2 86 6
BRK 87 4
SIK3 87 10
EPH-B3 87 3
OSR1 88 8
p38 delta MAPK 88 6
JNK3 89 10
PKC zeta 89 8
MPSK1 89 7
PIM3 89 3
PKA 89 2
TBK1 90 5
EPH-A2 90 2
CK2 90 3
BRSK1 91 5
NEK6 92 13
PIM1 92 5
CK1 gamma 2 92 1
MNK2 92 1
NEK2a 92 5
SRPK1 94 17
MEKK1 94 2
Lck 94 6
ROCK 2 94 1
RSK2 94 4
ERK2 95 5
ABL 95 7
PDGFRA 96 13
ERK1 96 6
PAK2 96 11
IRAK1 97 7
PKC gamma 97 2
TIE2 97 12
CDK2-Cyclin A 97 21
TESK1 97 4
EPH-B4 98 1
TLK1 99 17
CAMKK beta 99 2
TTK 100 1
p38 beta MAPK 100 0
PDK1 101 1
EPH-B1 101 11
S6K1 101 8
ASK1 101 6
PKC alpha 102 7
CHK1 102 5
PINK 102 4
MSK1 102 7
ZAP70 103 11
PLK1 103 1
WNK1 103 15
PRAK 103 10
IRR 103 9
DDR2 104 4
MAPKAP-K3 104 7
Aurora A 107 1
YES1 107 14
PIM2 108 7
MNK1 108 4
MAPKAP-K2 108 10
HER4 108 10
p38 alpha MAPK 113 7
TrkA 115 11
SYK 117 7
BTK 117 21
IGF-1R 118 8
EPH-A4 119 30
CSK 119 19
CDK9-Cyclin T1 126 1
EPH-B2 131 16
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
MAP4K5
5
 0
HIPK1
7
 0
MAP4K3 11 3
MLK3 12 1
PAK4 13 3
PAK5 16 1
TAK1 29 1
PAK6 29 1
TAO1 30 0
MLK1 30 4
JAK2 39 4
MARK3 41 6
PKD1 42 1
CK1 delta 45 6
TTBK1 47 10
TSSK1 49 2
TTBK2 52 10
MKK1 57 3
MINK1 58 4
CHK2 65 5
VEGFR1 67 5
EIF2AK3 71 7
MARK2 72 4
CLK2 73 3
IRAK4 75 6
MKK2 75 6
MARK1 76 16
p38 gamma MAPK 76 0
NUAK1 77 6
HIPK2 77 5
MARK4 79 0
MKK6 79 16
ULK2 79 13
SIK2 81 3
ERK5 81 2
EPH-A2 82 7
RSK1 83 20
OSR1 83 1
TGFBR1 83 1
SmMLCK 85 1
GSK3 beta 85 2
JNK2 85 12
p38 delta MAPK 86 1
JNK1 86 4
STK33 87 8
MELK 87 13
IKK epsilon 87 5
EPH-B3 87 2
DYRK3 88 6
RIPK2 88 4
PDGFRA 88 4
MNK1 89 0
RSK2 89 5
ULK1 89 14
EPH-B4 89 2
PKB beta 90 2
Aurora B 90 5
DYRK2 91 0
PKB alpha 91 1
DDR2 92 10
LKB1 92 15
DYRK1A 93 12
JNK3 93 14
PKC zeta 93 5
CAMKK beta 94 7
BRSK1 94 1
MAPKAP-K3 94 21
MNK2 95 1
IKK beta 95 18
PRK2 95 3
p38 beta MAPK 95 5
ERK8 96 0
IR 96 8
MEKK1 96 1
PHK 97 5
DAPK1 97 14
ERK1 97 8
S6K1 97 12
SRPK1 97 10
ROCK 2 97 1
EF2K 97 4
Lck 97 5
BRK 98 4
CAMK1 98 19
ZAP70 98 3
MST2 99 1
MST3 99 2
GCK 99 0
HIPK3 100 1
CDK9-Cyclin T1 100 3
CK2 100 9
BRSK2 101 0
CDK2-Cyclin A 101 1
TLK1 101 4
FGF-R1 101 14
PKA 102 1
Aurora A 102 5
PKC alpha 102 15
NEK6 103 21
IRAK1 103 8
SIK3 103 13
CK1 gamma 2 103 3
HER4 104 4
ABL 104 13
TBK1 104 2
MPSK1 104 0
PLK1 104 16
TESK1 105 3
MSK1 105 13
NEK2a 105 3
CHK1 105 3
EPH-B1 105 6
PKC gamma 105 3
IGF-1R 106 21
EPH-A4 106 21
MST4 107 1
WNK1 107 3
Src 107 0
MAPKAP-K2 108 10
PIM1 108 3
SYK 108 4
TTK 109 0
PIM3 109 0
PRAK 109 12
AMPK (hum) 109 14
PINK 110 6
PAK2 110 2
ASK1 110 1
SGK1 110 1
PDK1 111 11
BTK 113 2
TIE2 113 11
PIM2 115 10
ERK2 115 5
IRR 116 6
p38 alpha MAPK 117 13
YES1 118 8
CSK 124 3
EPH-B2 124 7
TrkA 127 6