Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
Capivasertib   C21HClN256O2 428.90 AKT
Capmatinib   C23H17FN6O 412.40 mutant MET
Catequentinib   C23H22FN3O3 407.40 VEGFRs
CAY10576   C22H19N3O5S2 469.50 IKKe
CCT250862 NEK
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13
Ceritinib   C28H36ClN5O3S 558.10 ALK
Cetuximab EGFR
CGP-57380   C11H9FN6 244.23 MNK Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511 Proud C.G. (2005) Immunity 23 177-189
CGP-57380 analog (SHN-093)   C12H11FN6 258.25 MNK Proud C.G. (2005) Immunity 23 177-189
CGP-57380 analog (SHN-095)   C13H14N6 254.29 MNK
Chelerythrine Chloride   C21H18NO4Cl 383.80 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707
CHIR 99021 (CT 99021)   C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588
Chloroquine   C18H26ClN3 319.87 Anti Malarial
CKI-7   C11H12ClN3O2S • 2HCl 358.67 CK1 Rena G. (2004) EMBO Rep. 5 60-65
Cobimetinib   C21H21F3IN3O2 531.30 MEK1/2
Compound C (Dorsomorphin)   C24H25N5O 399.50 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33 Kim E.K. (2004) J. Biol. Chem. 279 19970
Copanlisib   C23H28N8O4 PI3k, mTOR
Cot-Tpl2 Inhibitor Compound 10b (Abbott)   C20H15N3OS 345.42 Cot-Tpl2 Cusack K. (2009) Bioorganic and MedicinalChemistry Letters 19 1722-1725
Cot-Tpl2 Inhibitor Compound 38 (Abbott)   C21H12F3N5OS 439.41 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495…