Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
WNK-463 C21H24F3N7O2 463.46 WNK Yamada K (2016) Nat Chem Biol. 12(11) 896-898 Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 5
MKK2 127 12
MKK6 102 11
ERK1 105 2
ERK2 86 2
ERK5 101 1
JNK1 102 10
JNK2 92 11
JNK3 96 12
p38 alpha MAPK 96 5
p38 beta MAPK 113 7
p38 gamma MAPK 114 1
p38 delta MAPK 90 8
ERK8 102 7
RSK1 90 8
RSK2 90 4
PDK1 113 29
PKB alpha 115 1
PKB beta 100 16
SGK1 93 9
S6K1 95 14
PKA 105 6
ROCK 2 97 8
PRK2 99 1
PKC alpha 120 19
PKC gamma 98 6
PKC zeta 97 5
PKD1 105 10
STK33 116 17
MSK1 107 8
MNK1 117 3
MNK2 114 9
MAPKAP-K2 97 11
MAPKAP-K3 108 10
PRAK 102 19
CAMKK beta 97 10
CAMK1 103 8
SmMLCK 100 0
PHK 110 21
DAPK1 113 4
CHK1 102 15
CHK2 85 5
GSK3 beta 104 5
CDK2-Cyclin A 101 0
CDK9-Cyclin T1 101 5
PLK1 114 1
Aurora A 102 0
Aurora B 103 11
TLK1 105 4
LKB1 104 12
AMPK (hum) 116 6
MARK1 98 1
MARK2 88 6
MARK3 101 3
MARK4 124 9
BRSK1 90 2
BRSK2 104 8
MELK 67 8
NUAK1 114 1
SIK2 102 10
SIK3 94 21
TSSK1 106 1
CK1 gamma 2 95 12
CK1 delta 114 7
CK2 107 1
TTBK1 119 15
TTBK2 102 15
DYRK1A 106 7
DYRK2 17 15
DYRK3 109 7
NEK2a 99 8
NEK6 112 14
IKK beta 106 17
IKK epsilon 74 3
TBK1 103 14
PIM1 115 0
PIM2 98 3
PIM3 105 1
SRPK1 89 2
EF2K 97 5
EIF2AK3 84 1
HIPK1 95 7
HIPK2 102 19
HIPK3 88 4
CLK2 95 6
PAK2 89 3
PAK4 96 23
PAK5 105 12
PAK6 104 4
MST2 119 5
MST3 103 16
MST4 105 3
GCK 108 13
MAP4K3 97 4
MAP4K5 88 2
MINK1 102 8
MEKK1 108 11
MLK1 98 8
MLK3 91 3
TESK1 106 21
TAO1 87 10
ASK1 108 15
TAK1 114 13
IRAK1 113 38
IRAK4 120 23
RIPK2 99 9
OSR1 104 0
TTK 98 5
MPSK1 112 8
WNK1 9 3
ULK1 120 28
ULK2 80 3
TGFBR1 107 2
Src 105 22
Lck 105 13
CSK 100 1
YES1 116 6
ABL 111 15
BTK 108 9
JAK2 74 12
SYK 89 2
ZAP70 77 11
TIE2 98 6
BRK 115 1
EPH-A2 107 27
EPH-A4 112 13
EPH-B1 84 7
EPH-B2 128 7
EPH-B3 100 2
EPH-B4 92 22
FGF-R1 111 0
HER4 110 18
IGF-1R 105 35
IR 111 13
IRR 109 20
TrkA 60 22
DDR2 122 3
VEGFR1 101 2
PDGFRA 105 2
PINK 100 3

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