Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
NIK-Novartis-T1-7 C18H14N6OS 362.41 NIK US20120214762 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 112 5
MKK2 77 29
MKK6 97 7
ERK1 107 2
ERK2 115 21
ERK5 88 8
JNK1 109 1
JNK2 106 18
JNK3 111 14
p38 alpha MAPK 98 1
p38 beta MAPK 105 0
p38 gamma MAPK 92 3
p38 delta MAPK 106 11
ERK8 107 10
RSK1 94 6
RSK2 94 0
PDK1 115 6
PKB alpha 112 6
PKB beta 112 3
SGK1 98 3
S6K1 92 3
PKA 78 3
ROCK 2 117 11
PRK2 94 1
PKC alpha 107 1
PKC gamma 113 6
PKC zeta 123 10
PKD1 38 2
STK33 109 16
MSK1 98 19
MNK1 103 18
MNK2 115 26
MAPKAP-K2 120 14
MAPKAP-K3 98 9
PRAK 116 15
CAMKK beta 93 5
CAMK1 68 5
SmMLCK 98 11
PHK 108 14
DAPK1 109 2
CHK1 105 2
CHK2 107 5
GSK3 beta 107 4
CDK2-Cyclin A 95 2
CDK9-Cyclin T1 110 4
PLK1 94 8
Aurora A 129 12
Aurora B 66 1
TLK1 121 12
LKB1 111 0
AMPK (hum) 64 3
MARK1 117 7
MARK2 123 3
MARK3 93 11
MARK4 108 10
BRSK1 105 1
BRSK2 113 21
MELK 104 19
NUAK1 95 6
SIK2 102 3
SIK3 106 9
TSSK1 60 11
CK1 gamma 2 109 1
CK1 delta 95 5
CK2 93 3
TTBK1 105 6
TTBK2 117 19
DYRK1A 102 11
DYRK2 126 1
DYRK3 105 10
NEK2a 114 8
NEK6 105 1
IKK beta 103 8
IKK epsilon 105 1
TBK1 97 9
PIM1 103 9
PIM2 104 13
PIM3 100 20
SRPK1 93 6
EF2K 108 1
EIF2AK3 119 7
HIPK1 110 18
HIPK2 90 8
HIPK3 118 19
CLK2 107 0
PAK2 108 2
PAK4 78 7
PAK5 95 17
PAK6 86 15
MST2 118 9
MST3 107 7
MST4 98 5
GCK 119 11
MAP4K3 72 1
MAP4K5 31 2
MINK1 34 5
MEKK1 113 10
MLK1 80 0
MLK3 80 7
TESK1 90 11
TAO1 80 10
ASK1 132 20
TAK1 82 18
IRAK1 103 14
IRAK4 78 6
RIPK2 97 12
OSR1 123 8
TTK 112 2
MPSK1 122 12
WNK1 114 0
ULK1 114 7
ULK2 110 8
TGFBR1 130 33
Src 97 0
Lck 90 0
CSK 129 15
YES1 128 5
ABL 98 2
BTK 94 7
JAK2 107 19
SYK 107 15
ZAP70 122 9
TIE2 132 15
BRK 118 5
EPH-A2 111 9
EPH-A4 101 16
EPH-B1 110 6
EPH-B2 163 1
EPH-B3 130 12
EPH-B4 113 10
FGF-R1 92 22
HER4 92 2
IGF-1R 96 1
IR 112 4
IRR 119 6
TrkA 102 5
DDR2 101 13
VEGFR1 120 20
PDGFRA 73 0
PINK 116 13
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 10
MKK2 97 12
MKK6 83 2
ERK1 108 2
ERK2 100 15
ERK5 90 2
JNK1 100 6
JNK2 98 1
JNK3 84 7
p38 alpha MAPK 105 1
p38 beta MAPK 110 6
p38 gamma MAPK 96 12
p38 delta MAPK 107 1
ERK8 105 14
RSK1 89 2
RSK2 92 5
PDK1 110 1
PKB alpha 114 3
PKB beta 107 3
SGK1 68 7
S6K1 77 16
PKA 79 9
ROCK 2 111 13
PRK2 103 16
PKC alpha 115 11
PKC gamma 98 10
PKC zeta 121 4
PKD1 11 5
STK33 97 1
MSK1 108 2
MNK1 90 8
MNK2 78 1
MAPKAP-K2 98 1
MAPKAP-K3 102 13
PRAK 104 11
CAMKK beta 88 3
CAMK1 22 3
SmMLCK 105 19
PHK 104 1
DAPK1 103 8
CHK1 116 12
CHK2 97 12
GSK3 beta 107 3
CDK2-Cyclin A 91 7
CDK9-Cyclin T1 100 4
PLK1 100 5
Aurora A 116 3
Aurora B 66 3
TLK1 125 10
LKB1 103 4
AMPK (hum) 49 5
MARK1 109 1
MARK2 124 17
MARK3 97 7
MARK4 115 10
BRSK1 100 0
BRSK2 117 8
MELK 86 6
NUAK1 89 14
SIK2 102 3
SIK3 113 6
TSSK1 18 1
CK1 gamma 2 78 6
CK1 delta 62 11
CK2 101 4
TTBK1 107 2
TTBK2 111 12
DYRK1A 97 2
DYRK2 104 3
DYRK3 89 2
NEK2a 93 0
NEK6 106 1
IKK beta 90 5
IKK epsilon 66 3
TBK1 77 0
PIM1 100 3
PIM2 108 4
PIM3 95 1
SRPK1 101 8
EF2K 101 8
EIF2AK3 100 13
HIPK1 112 2
HIPK2 76 5
HIPK3 146 2
CLK2 51 5
PAK2 110 3
PAK4 32 3
PAK5 43 6
PAK6 51 2
MST2 103 4
MST3 100 8
MST4 81 4
GCK 90 7
MAP4K3 18 1
MAP4K5 8 5
MINK1 8 0
MEKK1 104 14
MLK1 34 5
MLK3 48 4
TESK1 82 6
TAO1 30 1
ASK1 111 4
TAK1 20 2
IRAK1 92 4
IRAK4 72 13
RIPK2 28 5
OSR1 110 7
TTK 106 11
MPSK1 94 9
WNK1 106 7
ULK1 110 3
ULK2 110 4
TGFBR1 124 11
Src 88 8
Lck 90 15
CSK 96 1
YES1 95 17
ABL 87 1
BTK 87 4
JAK2 113 9
SYK 89 7
ZAP70 117 9
TIE2 108 0
BRK 108 4
EPH-A2 123 4
EPH-A4 94 1
EPH-B1 109 4
EPH-B2 132 4
EPH-B3 115 2
EPH-B4 101 0
FGF-R1 63 18
HER4 93 8
IGF-1R 100 2
IR 106 1
IRR 100 4
TrkA 95 2
DDR2 81 13
VEGFR1 92 5
PDGFRA 28 0
PINK 105 0

Do you need any help? Please get in touch and we’ll be happy to lend a hand.