Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MLi-2 C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 355(3) 397-409 WO2014134774 Download

Results as Barchart

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10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
CLK2 2 1
TSSK1 13 3
NUAK1 16 3
JNK3 17 6
ASK1 20 1
CAMK1 24 4
CHK2 26 4
PRAK 31 8
STK33 31 4
SmMLCK 36 0
CAMKK beta 39 13
PHK 39 1
ERK5 40 4
JNK1 41 5
JNK2 43 10
AMPK (hum) 48 11
PIM3 49 7
PKD1 50 6
GCK 51 14
DYRK1A 52 5
TAK1 53 9
TrkA 53 3
TTK 53 4
DAPK1 54 0
MELK 55 8
ERK1 56 11
MLK1 56 4
DYRK2 59 2
RSK1 60 4
PIM1 61 3
OSR1 64 1
ERK2 66 3
Aurora B 68 1
MNK2 69 3
SRPK1 71 3
MKK1 73 7
ERK8 75 8
RSK2 75 12
FGF-R1 78 3
MKK2 78 12
BRSK1 79 8
PDGFRA 85 6
BRSK2 86 8
IRAK1 87 4
PKC zeta 88 6
MAP4K5 88 3
MAP4K3 89 3
MNK1 89 4
ULK2 89 1
IRR 91 6
CDK2-Cyclin A 91 2
IRAK4 92 1
EPH-A4 92 4
HIPK2 93 7
TESK1 94 4
DYRK3 94 1
ULK1 94 11
EPH-B1 94 11
TTBK1 94 7
EPH-B4 94 7
MLK3 95 7
ABL 97 3
DDR2 97 1
TIE2 97 13
PIM2 97 4
HIPK3 98 3
SGK1 99 1
IKK epsilon 99 2
TBK1 99 1
Src 99 19
MKK6 100 5
TTBK2 100 10
PKC gamma 100 0
CDK9-Cyclin T1 100 10
EF2K 100 8
MINK1 100 14
TLK1 100 1
CK1 delta 101 2
MARK1 102 1
BTK 102 2
PAK5 102 10
SYK 102 3
MAPKAP-K2 102 3
S6K1 103 1
Aurora A 103 7
MEKK1 103 14
CK1 gamma 2 104 7
HIPK1 104 7
PAK2 105 6
GSK3 beta 105 2
SIK3 105 7
MARK2 106 11
PKC alpha 106 3
CHK1 106 8
SIK2 106 9
PINK 107 13
ROCK 2 108 2
PAK4 108 13
IKK beta 108 7
p38 alpha MAPK 108 10
p38 beta MAPK 108 7
YES1 109 21
MARK4 109 8
JAK2 109 4
VEGFR1 109 18
PDK1 109 5
PKB alpha 109 7
IGF-1R 110 6
PAK6 110 1
MST3 110 5
LKB1 110 2
PRK2 111 7
MST4 111 2
MSK1 111 6
NEK6 112 3
p38 delta MAPK 112 8
Lck 113 15
MARK3 113 9
PKA 114 13
ZAP70 114 1
BRK 114 5
PLK1 114 7
PKB beta 115 5
NEK2a 115 16
p38 gamma MAPK 115 4
MPSK1 115 4
EIF2AK3 115 7
TGFBR1 115 1
MST2 116 5
RIPK2 116 3
WNK1 116 5
CK2 116 10
TAO1 120 14
MAPKAP-K3 120 14
IR 121 7
CSK 122 3
EPH-A2 122 7
EPH-B3 127 18
HER4 131 0
EPH-B2 136 14
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CLK2 17 1
TSSK1 47 3
ASK1 52 6
NUAK1 53 3
JNK3 57 3
CAMKK beta 73 8
STK33 77 1
ERK5 77 5
CAMK1 78 3
CHK2 81 3
TTK 84 10
PRAK 85 4
FGF-R1 85 3
DYRK1A 87 19
PHK 88 1
MKK2 88 3
IRAK1 89 1
JNK1 90 5
TAK1 90 2
RSK1 90 4
Src 90 3
BTK 91 3
DAPK1 92 3
EPH-B4 92 3
TESK1 92 9
JNK2 93 9
IRAK4 93 5
ERK8 93 5
MKK1 93 7
YES1 93 12
PKD1 94 11
SRPK1 94 13
TTBK2 94 19
ERK1 94 2
PAK5 95 2
SIK3 95 4
MAP4K3 95 11
S6K1 95 5
DYRK2 95 10
CDK9-Cyclin T1 96 11
PIM3 96 15
MARK2 97 12
MAP4K5 98 2
EF2K 98 3
IKK epsilon 99 9
GCK 99 1
OSR1 100 0
Aurora B 100 3
AMPK (hum) 100 5
SmMLCK 100 0
PAK2 100 11
MARK4 101 9
BRSK2 101 10
IKK beta 102 12
MELK 102 1
MST2 102 8
GSK3 beta 102 4
CK1 delta 102 15
CK2 102 1
TTBK1 102 3
MARK1 102 1
NEK6 103 8
SIK2 103 6
PIM1 103 4
MEKK1 103 2
ERK2 103 1
ABL 103 7
p38 beta MAPK 104 0
EPH-A4 104 2
Aurora A 104 3
RSK2 104 2
HIPK1 104 5
MARK3 104 0
BRSK1 105 1
MST3 105 13
ULK1 105 1
ULK2 105 2
EPH-B3 105 4
TAO1 105 9
TrkA 106 7
CHK1 106 4
p38 alpha MAPK 106 6
TIE2 106 7
TLK1 106 13
MSK1 107 6
CK1 gamma 2 107 0
PKB alpha 107 6
Lck 107 1
NEK2a 108 1
SYK 108 2
PIM2 108 4
PKB beta 108 10
JAK2 109 4
DDR2 109 15
PKC gamma 109 9
MST4 109 17
PINK 109 0
MNK1 109 8
MKK6 109 0
IGF-1R 109 9
DYRK3 109 6
ROCK 2 110 2
PKC zeta 110 6
MAPKAP-K2 110 7
MLK1 110 1
MLK3 110 8
PRK2 111 0
EPH-B1 111 2
MPSK1 112 4
PAK4 113 6
p38 gamma MAPK 113 13
p38 delta MAPK 113 7
HIPK2 113 3
PKA 113 3
IRR 114 7
PKC alpha 114 3
EPH-A2 114 14
MNK2 114 18
ZAP70 115 15
VEGFR1 115 18
MINK1 115 2
SGK1 115 12
HIPK3 115 11
EIF2AK3 116 4
LKB1 117 7
TBK1 118 12
PDGFRA 118 2
EPH-B2 118 9
TGFBR1 118 6
RIPK2 119 8
CSK 119 8
IR 119 12
WNK1 120 0
MAPKAP-K3 121 6
PLK1 123 5
CDK2-Cyclin A 124 3
PDK1 124 3
BRK 125 0
HER4 127 12
PAK6 128 9

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