Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MLi-2 C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 355(3) 397-409 WO2014134774 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 7
MKK2 88 3
MKK6 109 0
ERK1 94 2
ERK2 103 1
ERK5 77 5
JNK1 90 5
JNK2 93 9
JNK3 57 3
p38 alpha MAPK 106 6
p38 beta MAPK 104 0
p38 gamma MAPK 113 13
p38 delta MAPK 113 7
ERK8 93 5
RSK1 90 4
RSK2 104 2
PDK1 124 3
PKB alpha 107 6
PKB beta 108 10
SGK1 115 12
S6K1 95 5
PKA 113 3
ROCK 2 110 2
PRK2 111 0
PKC alpha 114 3
PKC gamma 109 9
PKC zeta 110 6
PKD1 94 11
STK33 77 1
MSK1 107 6
MNK1 109 8
MNK2 114 18
MAPKAP-K2 110 7
MAPKAP-K3 121 6
PRAK 85 4
CAMKK beta 73 8
CAMK1 78 3
SmMLCK 100 0
PHK 88 1
DAPK1 92 3
CHK1 106 4
CHK2 81 3
GSK3 beta 102 4
CDK2-Cyclin A 124 3
CDK9-Cyclin T1 96 11
PLK1 123 5
Aurora A 104 3
Aurora B 100 3
TLK1 106 13
LKB1 117 7
AMPK (hum) 100 5
MARK1 102 1
MARK2 97 12
MARK3 104 0
MARK4 101 9
BRSK1 105 1
BRSK2 101 10
MELK 102 1
NUAK1 53 3
SIK2 103 6
SIK3 95 4
TSSK1 47 3
CK1 gamma 2 107 0
CK1 delta 102 15
CK2 102 1
TTBK1 102 3
TTBK2 94 19
DYRK1A 87 19
DYRK2 95 10
DYRK3 109 6
NEK2a 108 1
NEK6 103 8
IKK beta 102 12
IKK epsilon 99 9
TBK1 118 12
PIM1 103 4
PIM2 108 4
PIM3 96 15
SRPK1 94 13
EF2K 98 3
EIF2AK3 116 4
HIPK1 104 5
HIPK2 113 3
HIPK3 115 11
CLK2 17 1
PAK2 100 11
PAK4 113 6
PAK5 95 2
PAK6 128 9
MST2 102 8
MST3 105 13
MST4 109 17
GCK 99 1
MAP4K3 95 11
MAP4K5 98 2
MINK1 115 2
MEKK1 103 2
MLK1 110 1
MLK3 110 8
TESK1 92 9
TAO1 105 9
ASK1 52 6
TAK1 90 2
IRAK1 89 1
IRAK4 93 5
RIPK2 119 8
OSR1 100 0
TTK 84 10
MPSK1 112 4
WNK1 120 0
ULK1 105 1
ULK2 105 2
TGFBR1 118 6
Src 90 3
Lck 107 1
CSK 119 8
YES1 93 12
ABL 103 7
BTK 91 3
JAK2 109 4
SYK 108 2
ZAP70 115 15
TIE2 106 7
BRK 125 0
EPH-A2 114 14
EPH-A4 104 2
EPH-B1 111 2
EPH-B2 118 9
EPH-B3 105 4
EPH-B4 92 3
FGF-R1 85 3
HER4 127 12
IGF-1R 109 9
IR 119 12
IRR 114 7
TrkA 106 7
DDR2 109 15
VEGFR1 115 18
PDGFRA 118 2
PINK 109 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 73 7
MKK2 78 12
MKK6 100 5
ERK1 56 11
ERK2 66 3
ERK5 40 4
JNK1 41 5
JNK2 43 10
JNK3 17 6
p38 alpha MAPK 108 10
p38 beta MAPK 108 7
p38 gamma MAPK 115 4
p38 delta MAPK 112 8
ERK8 75 8
RSK1 60 4
RSK2 75 12
PDK1 109 5
PKB alpha 109 7
PKB beta 115 5
SGK1 99 1
S6K1 103 1
PKA 114 13
ROCK 2 108 2
PRK2 111 7
PKC alpha 106 3
PKC gamma 100 0
PKC zeta 88 6
PKD1 50 6
STK33 31 4
MSK1 111 6
MNK1 89 4
MNK2 69 3
MAPKAP-K2 102 3
MAPKAP-K3 120 14
PRAK 31 8
CAMKK beta 39 13
CAMK1 24 4
SmMLCK 36 0
PHK 39 1
DAPK1 54 0
CHK1 106 8
CHK2 26 4
GSK3 beta 105 2
CDK2-Cyclin A 91 2
CDK9-Cyclin T1 100 10
PLK1 114 7
Aurora A 103 7
Aurora B 68 1
TLK1 100 1
LKB1 110 2
AMPK (hum) 48 11
MARK1 102 1
MARK2 106 11
MARK3 113 9
MARK4 109 8
BRSK1 79 8
BRSK2 86 8
MELK 55 8
NUAK1 16 3
SIK2 106 9
SIK3 105 7
TSSK1 13 3
CK1 gamma 2 104 7
CK1 delta 101 2
CK2 116 10
TTBK1 94 7
TTBK2 100 10
DYRK1A 52 5
DYRK2 59 2
DYRK3 94 1
NEK2a 115 16
NEK6 112 3
IKK beta 108 7
IKK epsilon 99 2
TBK1 99 1
PIM1 61 3
PIM2 97 4
PIM3 49 7
SRPK1 71 3
EF2K 100 8
EIF2AK3 115 7
HIPK1 104 7
HIPK2 93 7
HIPK3 98 3
CLK2 2 1
PAK2 105 6
PAK4 108 13
PAK5 102 10
PAK6 110 1
MST2 116 5
MST3 110 5
MST4 111 2
GCK 51 14
MAP4K3 89 3
MAP4K5 88 3
MINK1 100 14
MEKK1 103 14
MLK1 56 4
MLK3 95 7
TESK1 94 4
TAO1 120 14
ASK1 20 1
TAK1 53 9
IRAK1 87 4
IRAK4 92 1
RIPK2 116 3
OSR1 64 1
TTK 53 4
MPSK1 115 4
WNK1 116 5
ULK1 94 11
ULK2 89 1
TGFBR1 115 1
Src 99 19
Lck 113 15
CSK 122 3
YES1 109 21
ABL 97 3
BTK 102 2
JAK2 109 4
SYK 102 3
ZAP70 114 1
TIE2 97 13
BRK 114 5
EPH-A2 122 7
EPH-A4 92 4
EPH-B1 94 11
EPH-B2 136 14
EPH-B3 127 18
EPH-B4 94 7
FGF-R1 78 3
HER4 131 0
IGF-1R 110 6
IR 121 7
IRR 91 6
TrkA 53 3
DDR2 97 1
VEGFR1 109 18
PDGFRA 85 6
PINK 107 13

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