Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
EMD638683 C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8 US2011060050 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
SGK1 7 3
PKA 17 0
MSK1 22 2
PRK2 34 5
PKB alpha 58 6
MST3 69 50
AMPK (hum) 73 1
ERK8 73 18
HIPK2 75 0
PKB beta 81 10
HIPK3 81 10
CK1 gamma 2 82 5
Lck 83 7
YES1 83 5
HIPK1 84 14
MARK1 84 5
HER4 85 28
TSSK1 86 3
RSK1 87 6
S6K1 87 4
IRAK1 87 3
RSK2 89 14
GSK3 beta 90 8
ROCK 2 91 18
BRSK1 91 15
MELK 91 6
ULK2 92 4
DYRK1A 92 6
CLK2 92 10
TAO1 92 1
SmMLCK 92 14
PKC gamma 92 4
MNK2 93 7
CAMK1 93 12
ZAP70 93 7
TTK 93 2
MEKK1 94 1
MST2 94 18
PAK5 95 7
MAPKAP-K3 96 4
PAK2 96 4
Aurora A 97 8
EPH-B4 97 10
CAMKK beta 97 7
MARK4 97 6
p38 alpha MAPK 97 2
EF2K 98 9
ERK2 98 12
DYRK2 98 3
IR 98 3
JAK2 98 11
MLK3 99 7
ABL 99 6
OSR1 99 14
CDK2-Cyclin A 99 14
MAP4K5 100 5
Aurora B 100 6
VEGFR1 100 31
STK33 100 10
CK1 delta 101 19
MKK1 101 2
PRAK 101 6
IRR 101 3
IRAK4 101 4
SIK2 101 14
p38 delta MAPK 101 17
JNK1 102 7
IKK beta 102 2
PAK6 102 7
PKC zeta 102 21
EPH-B2 103 22
MKK2 103 19
TTBK1 103 0
FGF-R1 103 12
JNK2 103 8
EIF2AK3 104 10
MARK3 104 12
PAK4 104 24
TAK1 104 8
TrkA 104 14
IKK epsilon 104 24
PKD1 104 21
PIM2 104 3
PDK1 105 0
ASK1 105 1
BRSK2 105 4
DDR2 105 25
TBK1 105 0
CDK9-Cyclin T1 105 1
SIK3 105 9
PIM3 105 14
DYRK3 106 13
NEK6 106 9
PKC alpha 106 3
GCK 106 34
MAP4K3 106 26
EPH-B1 107 7
PHK 107 11
MARK2 108 15
IGF-1R 108 11
CHK2 108 1
TLK1 109 8
DAPK1 109 1
CHK1 109 14
PDGFRA 109 8
PIM1 109 7
LKB1 110 23
NUAK1 110 2
p38 gamma MAPK 110 3
ULK1 111 13
BTK 111 2
WNK1 111 8
MLK1 112 20
RIPK2 112 5
p38 beta MAPK 112 15
SRPK1 113 9
CSK 113 9
NEK2a 113 31
MNK1 114 21
CK2 114 15
JNK3 114 22
EPH-A4 114 2
MAPKAP-K2 115 11
TTBK2 115 11
ERK1 116 29
MPSK1 116 17
BRK 117 1
Src 118 3
ERK5 119 6
TESK1 120 32
MINK1 122 10
TGFBR1 123 3
SYK 123 2
MST4 123 4
TIE2 124 22
PLK1 124 3
EPH-B3 128 5
MKK6 128 9
EPH-A2 137 27
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
SGK1 14 10
PKA 65 12
MSK1 66 5
YES1 73 5
VEGFR1 76 2
CDK2-Cyclin A 79 14
Lck 79 8
MELK 81 3
PRK2 81 19
MNK1 83 7
PKB alpha 83 2
IRAK1 83 6
SIK2 85 6
AMPK (hum) 85 0
ULK2 86 6
PKB beta 87 15
HIPK3 87 9
Aurora B 88 4
CK1 delta 88 17
RSK2 89 5
IGF-1R 89 21
GSK3 beta 90 11
PAK2 90 1
ROCK 2 90 1
MST2 91 13
CDK9-Cyclin T1 91 3
MARK1 91 7
DYRK1A 91 6
HER4 91 3
MARK4 91 5
JAK2 91 1
TSSK1 92 5
HIPK2 92 7
CAMK1 92 12
PAK4 92 2
RSK1 93 1
SIK3 94 15
MAP4K3 94 18
MNK2 94 20
CLK2 94 18
DAPK1 94 12
PAK5 94 2
PKC gamma 96 17
MEKK1 96 5
SmMLCK 96 14
BRSK1 96 1
DDR2 96 11
p38 alpha MAPK 97 9
IKK epsilon 97 14
ZAP70 97 5
EF2K 97 32
MLK3 97 15
PAK6 97 12
p38 delta MAPK 98 25
Aurora A 98 7
MAPKAP-K3 98 10
PRAK 98 3
ABL 98 5
MST3 99 5
PDGFRA 99 3
STK33 99 7
IR 99 8
ERK8 100 11
TTBK1 100 9
TTBK2 100 4
TESK1 100 11
ERK2 100 11
S6K1 100 5
TAK1 100 8
IKK beta 100 18
p38 gamma MAPK 101 15
LKB1 101 4
ERK1 101 2
TAO1 101 0
JNK2 101 14
PKC alpha 101 1
PIM1 102 2
MAPKAP-K2 102 8
IRR 102 1
CHK2 103 5
PKD1 103 10
PDK1 103 1
Src 103 1
CAMKK beta 103 7
BTK 103 3
PIM2 104 4
MARK3 104 11
PIM3 105 11
TLK1 105 6
HIPK1 105 7
JNK3 105 9
MINK1 106 26
MKK1 106 5
PHK 106 14
MST4 107 3
SRPK1 107 19
OSR1 108 13
DYRK3 108 7
ASK1 108 9
EPH-A2 109 14
MAP4K5 109 18
MKK2 109 28
DYRK2 109 11
CHK1 109 7
ULK1 110 13
CK2 110 3
EPH-B4 110 7
CSK 110 25
NEK2a 110 22
BRSK2 110 14
PKC zeta 111 25
PLK1 111 7
EPH-A4 111 1
ERK5 111 19
IRAK4 111 5
SYK 111 9
p38 beta MAPK 112 4
GCK 112 31
NEK6 112 13
JNK1 113 15
NUAK1 114 18
TTK 114 23
CK1 gamma 2 114 41
MLK1 114 19
MKK6 114 3
FGF-R1 114 8
MARK2 114 13
TrkA 114 30
EIF2AK3 115 26
EPH-B3 115 11
MPSK1 116 7
TIE2 117 15
TBK1 119 16
WNK1 119 11
TGFBR1 119 9
EPH-B1 123 30
RIPK2 124 19
BRK 129 27
EPH-B2 137 51

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