Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
EMD638683 C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8 US2011060050 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 106 5
MKK2 109 28
MKK6 114 3
ERK1 101 2
ERK2 100 11
ERK5 111 19
JNK1 113 15
JNK2 101 14
JNK3 105 9
p38 alpha MAPK 97 9
p38 beta MAPK 112 4
p38 gamma MAPK 101 15
p38 delta MAPK 98 25
ERK8 100 11
RSK1 93 1
RSK2 89 5
PDK1 103 1
PKB alpha 83 2
PKB beta 87 15
SGK1 14 10
S6K1 100 5
PKA 65 12
ROCK 2 90 1
PRK2 81 19
PKC alpha 101 1
PKC gamma 96 17
PKC zeta 111 25
PKD1 103 10
STK33 99 7
MSK1 66 5
MNK1 83 7
MNK2 94 20
MAPKAP-K2 102 8
MAPKAP-K3 98 10
PRAK 98 3
CAMKK beta 103 7
CAMK1 92 12
SmMLCK 96 14
PHK 106 14
DAPK1 94 12
CHK1 109 7
CHK2 103 5
GSK3 beta 90 11
CDK2-Cyclin A 79 14
CDK9-Cyclin T1 91 3
PLK1 111 7
Aurora A 98 7
Aurora B 88 4
TLK1 105 6
LKB1 101 4
AMPK (hum) 85 0
MARK1 91 7
MARK2 114 13
MARK3 104 11
MARK4 91 5
BRSK1 96 1
BRSK2 110 14
MELK 81 3
NUAK1 114 18
SIK2 85 6
SIK3 94 15
TSSK1 92 5
CK1 gamma 2 114 41
CK1 delta 88 17
CK2 110 3
TTBK1 100 9
TTBK2 100 4
DYRK1A 91 6
DYRK2 109 11
DYRK3 108 7
NEK2a 110 22
NEK6 112 13
IKK beta 100 18
IKK epsilon 97 14
TBK1 119 16
PIM1 102 2
PIM2 104 4
PIM3 105 11
SRPK1 107 19
EF2K 97 32
EIF2AK3 115 26
HIPK1 105 7
HIPK2 92 7
HIPK3 87 9
CLK2 94 18
PAK2 90 1
PAK4 92 2
PAK5 94 2
PAK6 97 12
MST2 91 13
MST3 99 5
MST4 107 3
GCK 112 31
MAP4K3 94 18
MAP4K5 109 18
MINK1 106 26
MEKK1 96 5
MLK1 114 19
MLK3 97 15
TESK1 100 11
TAO1 101 0
ASK1 108 9
TAK1 100 8
IRAK1 83 6
IRAK4 111 5
RIPK2 124 19
OSR1 108 13
TTK 114 23
MPSK1 116 7
WNK1 119 11
ULK1 110 13
ULK2 86 6
TGFBR1 119 9
Src 103 1
Lck 79 8
CSK 110 25
YES1 73 5
ABL 98 5
BTK 103 3
JAK2 91 1
SYK 111 9
ZAP70 97 5
TIE2 117 15
BRK 129 27
EPH-A2 109 14
EPH-A4 111 1
EPH-B1 123 30
EPH-B2 137 51
EPH-B3 115 11
EPH-B4 110 7
FGF-R1 114 8
HER4 91 3
IGF-1R 89 21
IR 99 8
IRR 102 1
TrkA 114 30
DDR2 96 11
VEGFR1 76 2
PDGFRA 99 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 2
MKK2 103 19
MKK6 128 9
ERK1 116 29
ERK2 98 12
ERK5 119 6
JNK1 102 7
JNK2 103 8
JNK3 114 22
p38 alpha MAPK 97 2
p38 beta MAPK 112 15
p38 gamma MAPK 110 3
p38 delta MAPK 101 17
ERK8 73 18
RSK1 87 6
RSK2 89 14
PDK1 105 0
PKB alpha 58 6
PKB beta 81 10
SGK1 7 3
S6K1 87 4
PKA 17 0
ROCK 2 91 18
PRK2 34 5
PKC alpha 106 3
PKC gamma 92 4
PKC zeta 102 21
PKD1 104 21
STK33 100 10
MSK1 22 2
MNK1 114 21
MNK2 93 7
MAPKAP-K2 115 11
MAPKAP-K3 96 4
PRAK 101 6
CAMKK beta 97 7
CAMK1 93 12
SmMLCK 92 14
PHK 107 11
DAPK1 109 1
CHK1 109 14
CHK2 108 1
GSK3 beta 90 8
CDK2-Cyclin A 99 14
CDK9-Cyclin T1 105 1
PLK1 124 3
Aurora A 97 8
Aurora B 100 6
TLK1 109 8
LKB1 110 23
AMPK (hum) 73 1
MARK1 84 5
MARK2 108 15
MARK3 104 12
MARK4 97 6
BRSK1 91 15
BRSK2 105 4
MELK 91 6
NUAK1 110 2
SIK2 101 14
SIK3 105 9
TSSK1 86 3
CK1 gamma 2 82 5
CK1 delta 101 19
CK2 114 15
TTBK1 103 0
TTBK2 115 11
DYRK1A 92 6
DYRK2 98 3
DYRK3 106 13
NEK2a 113 31
NEK6 106 9
IKK beta 102 2
IKK epsilon 104 24
TBK1 105 0
PIM1 109 7
PIM2 104 3
PIM3 105 14
SRPK1 113 9
EF2K 98 9
EIF2AK3 104 10
HIPK1 84 14
HIPK2 75 0
HIPK3 81 10
CLK2 92 10
PAK2 96 4
PAK4 104 24
PAK5 95 7
PAK6 102 7
MST2 94 18
MST3 69 50
MST4 123 4
GCK 106 34
MAP4K3 106 26
MAP4K5 100 5
MINK1 122 10
MEKK1 94 1
MLK1 112 20
MLK3 99 7
TESK1 120 32
TAO1 92 1
ASK1 105 1
TAK1 104 8
IRAK1 87 3
IRAK4 101 4
RIPK2 112 5
OSR1 99 14
TTK 93 2
MPSK1 116 17
WNK1 111 8
ULK1 111 13
ULK2 92 4
TGFBR1 123 3
Src 118 3
Lck 83 7
CSK 113 9
YES1 83 5
ABL 99 6
BTK 111 2
JAK2 98 11
SYK 123 2
ZAP70 93 7
TIE2 124 22
BRK 117 1
EPH-A2 137 27
EPH-A4 114 2
EPH-B1 107 7
EPH-B2 103 22
EPH-B3 128 5
EPH-B4 97 10
FGF-R1 103 12
HER4 85 28
IGF-1R 108 11
IR 98 3
IRR 101 3
TrkA 104 14
DDR2 105 25
VEGFR1 100 31
PDGFRA 109 8

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