Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SGK1-Sanofi-14h C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters , 6,73-78 Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 7
MKK2 70 5
MKK6 91 10
ERK1 95 14
ERK2 99 7
ERK5 119 3
JNK1 94 3
JNK2 100 3
JNK3 102 3
p38 alpha MAPK 117 0
p38 beta MAPK 97 5
p38 gamma MAPK 104 2
p38 delta MAPK 114 17
ERK8 38 1
RSK1 48 1
RSK2 77 23
PDK1 96 15
PKB alpha 105 20
PKB beta 98 6
SGK1 6 1
S6K1 3 0
PKA 109 5
ROCK 2 117 14
PRK2 89 11
PKC alpha 106 6
PKC gamma 111 14
PKC zeta 97 9
PKD1 87 1
STK33 105 8
MSK1 31 0
MNK1 104 4
MNK2 97 3
MAPKAP-K2 114 9
MAPKAP-K3 122 6
PRAK 107 4
CAMKK beta 100 6
CAMK1 63 3
SmMLCK 101 1
PHK 109 1
DAPK1 105 10
CHK1 112 17
CHK2 50 5
GSK3 beta 97 3
CDK2-Cyclin A 104 6
CDK9-Cyclin T1 107 3
PLK1 108 8
Aurora A 100 6
Aurora B 42 7
TLK1 112 11
LKB1 97 1
AMPK (hum) 96 1
MARK1 130 17
MARK2 95 8
MARK3 95 8
MARK4 106 5
BRSK1 104 6
BRSK2 97 12
MELK 67 4
NUAK1 61 7
SIK2 101 1
SIK3 102 12
TSSK1 99 8
CK1 gamma 2 81 1
CK1 delta 100 4
CK2 128 3
TTBK1 100 8
TTBK2 110 12
DYRK1A 94 4
DYRK2 109 16
DYRK3 94 4
NEK2a 103 1
NEK6 105 5
IKK beta 100 2
IKK epsilon 69 2
TBK1 94 5
PIM1 111 4
PIM2 100 15
PIM3 102 10
SRPK1 108 0
EF2K 98 2
EIF2AK3 81 6
HIPK1 92 9
HIPK2 45 4
HIPK3 98 5
CLK2 90 3
PAK2 110 8
PAK4 46 4
PAK5 87 6
PAK6 101 7
MST2 99 8
MST3 91 7
MST4 104 9
GCK 34 3
MAP4K3 25 3
MAP4K5 13 3
MINK1 71 7
MEKK1 114 14
MLK1 10 0
MLK3 6 0
TESK1 111 10
TAO1 90 2
ASK1 121 18
TAK1 45 4
IRAK1 90 2
IRAK4 108 3
RIPK2 95 1
OSR1 99 10
TTK 77 1
MPSK1 114 2
WNK1 103 8
ULK1 100 7
ULK2 84 2
TGFBR1 78 20
Src 115 12
Lck 111 12
CSK 129 9
YES1 95 16
ABL 90 6
BTK 89 6
JAK2 77 6
SYK 101 5
ZAP70 110 16
TIE2 10 1
BRK 100 12
EPH-A2 117 11
EPH-A4 111 5
EPH-B1 98 9
EPH-B2 103 2
EPH-B3 99 10
EPH-B4 99 5
FGF-R1 115 11
HER4 103 7
IGF-1R 97 12
IR 82 8
IRR 105 1
TrkA 101 13
DDR2 105 1
VEGFR1 73 1
PDGFRA 89 6
PINK 99 7

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